A5100328675- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Nerve injury and regeneration
- SARS-CoV-2 and COVID-19 Research
- Osteoarthritis Treatment and Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Bacterial Infections and Vaccines
- Inflammatory mediators and NSAID effects
- Immunotherapy and Immune Responses
- Peroxisome Proliferator-Activated Receptors
- Systemic Lupus Erythematosus Research
- Influenza Virus Research Studies
- Nuclear Receptors and Signaling
- Cancer-related molecular mechanisms research
- Calpain Protease Function and Regulation
- Rheumatoid Arthritis Research and Therapies
- Neurotransmitter Receptor Influence on Behavior
- GABA and Rice Research
- Genetic Associations and Epidemiology
- Computational Drug Discovery Methods
- Ferroptosis and cancer prognosis
- Pain Management and Placebo Effect
- Endometriosis Research and Treatment
- RNA regulation and disease
- Cell death mechanisms and regulation
Gansu Provincial Hospital
2023-2025
Second Xiangya Hospital of Central South University
2023-2024
Central South University
2023-2024
Central China Normal University
2023
Fujian University of Traditional Chinese Medicine
2022-2023
University of Macau
2023
Jilin Province Tumor Hospital
2023
University of Kentucky
1995-2017
Albert B. Chandler Hospital
2011
Developing a novel and potent adjuvant with great biocompatibility for immune response augmentation is of significance to enhance vaccine efficacy. In this work, we prepared long-term stable, pH-sensitive, biodegradable Mn3(PO4)2·3H2O nanoparticle (nano-MnP) by simply mixing MnCl2/NaH2PO4/Na2HPO4 solution the first time employed it as an stimulant in bivalent COVID-19 protein comprised wild-type S1 (S1-WT) Omicron (S1-Omicron) proteins antigens elicit broad-spectrum immunity. The biological...
Abstract Effects of a single injection either 150 μg human recombinant glial cell line‐derived neurotrophic factor (rGDNF) or vehicle into the right substantia nigra were analyzed in 12 normal adult female rhesus monkeys. The studies included evaluating whole animal behavior, electrochemical recordings striatal dopamine release, neurochemical determinations basal ganglia and nigral monoamine levels, immunohistochemical staining nigrostriatal system. behavioral effects over 3–week observation...
Dysfunction and death of midbrain dopaminergic neurons underlies the clinical features Parkinson's disease (PD). Increasing evidence suggests roles for oxidative stress a form cell called apoptosis in pathogenesis PD. We recently identified 38-kd protein prostate response-4 (Par-4), which is rapidly induced cultured after exposure to apoptotic insults, appears play necessary role process. now report that Par-4 levels increase dramatically monkeys mice exposed...
Abstract For these studies, young (8–9 years), middle‐aged (14–17 years) and aged (23–28 rhesus monkeys were used as a model of normal aging in humans to investigate changes dopamine (DA)‐containing neurons senescence. Aged exhibited significant age‐related motoric declines compared the animals. In vivo microdialysis studies showed that basal levels DA metabolites, homovanillic acid (HVA) 3,4‐dihydroxyphenylacetic (DOPAC) diminished by 44% 79%, respectively, in␣the substantia nigra (SN)...
Gastric cancer (GC) has a poor prognosis, considerable cellular heterogeneity, and ranks fifth among malignant tumours. Understanding the tumour microenvironment (TME) intra-tumor heterogeneity (ITH) may lead to development of novel GC treatments. The single-cell RNA sequencing (scRNA-seq) dataset was obtained from Gene Expression Omnibus (GEO) database, where diverse immune cells were isolated re-annotated based on cell markers established in original study ascertain their individual...
Exploring potent adjuvants and new vaccine strategies is crucial for the development of protein vaccines. In this work, we synthesized a TLR4 agonist, structurally simplified lipid A analogue GAP112, as built-in adjuvant to improve immunogenicity SARS-CoV-2 spike RBD protein. The agonist GAP112 was site-selectively conjugated on N-terminus construct an adjuvant–protein conjugate in liposomal formulation. It first time that site-specifically quantitatively antigen. Compared with unconjugated...
Context: Endometriosis, the growth of endometrial tissue outside uterus, is principally an estrogen-dependent disease. In contrast, exposure to progesterone during pregnancy or therapeutically has been shown provide benefit some women with this However, recent research suggests that presence endometriosis impairs capacity eutopic endometrium respond endogenous progesterone.
Modification of antigens to improve their immunogenicity represents a promising direction for the development protein vaccine. Here, we designed facilely prepared adjuvant-free vaccines in which N-glycan SARS-CoV-2 receptor-binding domain (RBD) glycoprotein was oxidized by sodium periodate. This strategy only minimally modifies glycans and does not interfere with epitope peptides. The RBD high concentrations periodate (RBDHO) significantly enhanced antigen uptake mediated scavenger receptors...
Osteoarthritis (OA) is a common degenerative joint disease and causes chronic pain disability to the elderly. Several risk factors are involved, such as aging, obesity, genetic susceptibility, environmental factors. We conducted transcriptome-wide association study (TWAS) chemical-related gene set enrichment analysis (CGSEA) investigate susceptibility genes factors.TWAS was identify by integrating summary-level genome-wide data of knee OA (KOA) hip (HOA) with precomputed expression weights...
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease involving multiple organs throughout the body. The health care-seeking behaviors, progression of SLE, and patients' knowledge attitudes toward SLE have not been characterized in China.The aim this study was to depict progression, medications patients with examine factors associated their flares, knowledge, China.We conducted cross-sectional survey 27 provinces China. Descriptive statistical methods were used demographic...
Abstract Background Individuals with osteoarthritis present comorbidities, and the potential causal associations remain incompletely elucidated. The study undertook a large-scale investigation about causality between variable traits, using summary-level data of genome-wide association studies (GWAS). Methods included GWS knee osteoarthritis, hip or hand other 1355 traits. Genetic correlation analysis was conducted traits through cross-trait bivariate linkage disequilibrium score regression....
<sec> <title>BACKGROUND</title> Systemic lupus erythematosus (SLE) is a systemic autoimmune disease involving multiple organs throughout the body. The health care–seeking behaviors, progression of SLE, and patients' knowledge attitudes toward SLE have not been characterized in China. </sec> <title>OBJECTIVE</title> aim this study was to depict progression, medications patients with examine factors associated their flares, knowledge, <title>METHODS</title> We conducted cross-sectional survey...