A5048689548- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Innovation and Knowledge Management
- Glycosylation and Glycoproteins Research
- Immune Response and Inflammation
- Knowledge Management and Sharing
- Monoclonal and Polyclonal Antibodies Research
- Human Pose and Action Recognition
- 3D Shape Modeling and Analysis
- Membrane Separation Technologies
- Advanced Vision and Imaging
- Advanced Antenna and Metasurface Technologies
- Cryptographic Implementations and Security
- Bacterial Infections and Vaccines
- Intellectual Capital and Performance Analysis
- Advanced battery technologies research
- Coding theory and cryptography
- interferon and immune responses
- Chaos-based Image/Signal Encryption
- Antenna Design and Analysis
- Metamaterials and Metasurfaces Applications
- Digital Marketing and Social Media
- Image Enhancement Techniques
- Social Capital and Networks
- Innovation Diffusion and Forecasting
Westlake University
2024-2025
Central China Normal University
2019-2024
Nankai University
2024
Nanjing University
2019-2024
Xiamen University of Technology
2021-2023
Xiamen University
2021-2022
Jishou University
2020-2022
Xiangtan University
2020-2022
Nanjing Normal University
2022
Hubei University
2021
Large volumes of product reviews generated by online users have important strategic value for development. Prior studies often focus on the influence customers' purchasing decisions through word-of-mouth effect. However, little is known about how developers respond to these reviews. This study adopts a big data analytical approach investigate impact customer agility and subsequently performance. We develop singular decomposition-based semantic keyword similarity method quantify using...
Purpose The aim of this study is to explore the role social tie content in interpersonal knowledge transfer process and test effects different ties, i.e. distinguishing instrumental expressive tie, on transfer, using cognition‐ affect‐based trust as mediators. Design/methodology/approach A theoretical model was tested through a survey carried out 152 MBA students university east China, structural equation modelling (SEM) employed for data analysis. Findings This research proved that both...
Safe and effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) its variants are the best approach to successfully combat COVID-19 pandemic. The receptor-binding domain (RBD) of viral spike protein is a major target develop candidate vaccines. α-Galactosylceramide (αGalCer), potent invariant natural killer T cell (iNKT) agonist, was site-specifically conjugated
Safe and effective vaccines are the best method to defeat worldwide SARS-CoV-2 its circulating variants. The S protein subunits most attractive targets for development of protein-based vaccines. In this study, we evaluated three lipophilic adjuvants, monophosphoryl lipid A (MPLA), Toll-like receptor (TLR) 1/2 ligand Pam3CSK4, α-galactosylceramide (α-GalCer), in liposomal nonliposomal immunological results showed that MPLA-adjuvanted vaccine induced strongest humoral cellular immunity....
Developing a novel and potent adjuvant with great biocompatibility for immune response augmentation is of significance to enhance vaccine efficacy. In this work, we prepared long-term stable, pH-sensitive, biodegradable Mn3(PO4)2·3H2O nanoparticle (nano-MnP) by simply mixing MnCl2/NaH2PO4/Na2HPO4 solution the first time employed it as an stimulant in bivalent COVID-19 protein comprised wild-type S1 (S1-WT) Omicron (S1-Omicron) proteins antigens elicit broad-spectrum immunity. The biological...
Weak antigens represented by MUC1 are poorly immunogenic, which greatly constrains the development of relevant vaccines. Herein, we developed a multifunctional lipidated protein as carrier, in TLR1/2 agonist Pam3CSK4 was conjugated to N-terminus MUC1-loaded carrier BSA through pyridoxal 5′-phosphate-mediated transamination reaction. The resulting Pam3CSK4–BSA-MUC1 conjugate subsequently incorporated into liposomes, biomimics membrane structure tumor cells. results indicated that this...
Synthetic α-galactosylceramide (αGalCer) and its analogues as powerful agonists for natural killer T (NKT) cell manipulation have received significant attention in immunotherapy adjuvant development. However, identifying new potent NKT agonists, especially those with Th1 selectivity that promote anticancer effects, remains a challenging task. In this work, we introduced sulfonamide group into the acyl chain of αGalCer to form additional hydrogen bonds intensify glycolipid/CD1d interaction....
A deep learning based homogenization framework is proposed to link the microstructures of porous nickel/yttria-stabilized zirconia anodes in solid oxide fuel cells (SOFCs) their effective macroscopic properties. variety are generated by discrete element method and meso‑scale kinetic Monte Carlo method. Then, finite theory used calculate elastic modulus (E), Poisson's ratio (υ), shear (G) coefficient thermal expansion (CTE) representative volume elements. In addition, triple-phase boundary...
The coronavirus 2019 (COVID-19) pandemic is causing serious impacts in the world, and safe effective vaccines medicines are best methods to combat disease. receptor-binding domain (RBD) of SARS-CoV-2 spike protein plays a key role interacting with angiotensin-converting enzyme 2 (ACE2) receptor, regarded as an important target vaccines. Herein, we constructed adjuvant-protein conjugate Pam3CSK4-RBD vaccine candidate, which N-terminal RBD was site-selectively oxidized by transamination...
The tumor-associated antigen mucin 1 (MUC1) is an attractive target of antitumor vaccine, but its weak immunogenicity a big challenge for the development vaccine. In order to enhance immune responses against MUC1, herein, we conjugated small molecular toll-like receptor 7 agonist (TLR7a) carrier protein BSA via MUC1 glycopeptide form three-component conjugate (BSA-MUC1-TLR7a). Furthermore, combined with Alum adjuvant explore their synergistic effects. immunological studies indicated that and...
Abstract Recent advancements in genetically encoded calcium indicators, particularly those based on green fluorescent proteins, have optimized their performance for monitoring neuronal activities a variety of model organisms. However, progress developing red-shifted GECIs, despite advantages over has been slower, resulting fewer options end-users. In this study, we explored topological inversion and soma-targeting strategies, which are complementary to conventional mutagenesis, re-engineer...
Many cancer vaccines are not successful in clinical trials, mainly due to the challenges associated with breaking immune tolerance. Herein, we report a new strategy using an adjuvant-protein-antigen (three-in-one protein conjugates built-in adjuvant) as anticancer vaccine, which both adjuvant (small-molecule TLR7 agonist) and tumor-associated antigen (mucin 1, MUC1) covalently conjugated same carrier (BSA). It is shown that can increase adjuvant's stimulation, prevent systemic toxicities,...
Exploring potent adjuvants and new vaccine strategies is crucial for the development of protein vaccines. In this work, we synthesized a TLR4 agonist, structurally simplified lipid A analogue GAP112, as built-in adjuvant to improve immunogenicity SARS-CoV-2 spike RBD protein. The agonist GAP112 was site-selectively conjugated on N-terminus construct an adjuvant–protein conjugate in liposomal formulation. It first time that site-specifically quantitatively antigen. Compared with unconjugated...
Adjuvants are important components in vaccines to increase the immunogenicity of proteins and induce optimal immunity. In this study, we designed a novel ternary adjuvant system Alum + c-GAMP poly(I:C) with STING agonist 3,3'-c-GAMP (c-GAMP) TLR3 co-adsorbed on conventional aluminum gel (Alum), further constructed an S1 protein vaccine. Two doses vaccination vaccine were sufficient balanced Th1/Th2 immune response robust humoral cellular Additionally, group had effective neutralizing...
With the global pandemic of new coronavirus disease (COVID-19), a safe, effective, and affordable mass-produced vaccine remains current focus research. Herein, we designed an adjuvant-protein conjugate candidate, in which TLR7 agonist (TLR7a) was conjugated to S1 subunit SARS-CoV-2 spike protein, systematically compared effect different numbers built-in TLR7a on immune activity for first time. As number increased, bell-shaped reaction observed three TLR7a-S1 conjugates, with TLR7a(10)-S1...