A5101657375- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
- Click Chemistry and Applications
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Reactions
- Sulfur-Based Synthesis Techniques
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Radioactive element chemistry and processing
- Pneumonia and Respiratory Infections
- Biotin and Related Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Peptidase Inhibition and Analysis
- Radical Photochemical Reactions
- Multicomponent Synthesis of Heterocycles
- Immune Response and Inflammation
- Advanced Biosensing Techniques and Applications
- T-cell and B-cell Immunology
- Synthetic Organic Chemistry Methods
- Complement system in diseases
- Polyoxometalates: Synthesis and Applications
- Coordination Chemistry and Organometallics
- Microfluidic and Capillary Electrophoresis Applications
- CAR-T cell therapy research
East China University of Technology
2018-2024
Central China Normal University
2015-2018
Visible-light-induced specific desulfurization of cysteinyl peptides has been explored. The photocatalytic catalyzed by Ru(bpy)32+ can proceed efficiently at room temperature in aqueous solution or binary mixtures aqueous/organic solvent and be compatible with the presence residues amino acids, carbohydrates, various sulfur-containing functional groups. This approach was successfully applied to synthesize linear cyclic through ligation–desulfurization protocol.
Open AccessCCS ChemistryCOMMUNICATION1 Apr 2022Abundant Production of Reactive Water Radical Cations under Ambient Conditions Meng Wang†, Xiao-Fei Gao†, Rui Su, Peng He, Yuan-Yuan Cheng, Ke Li, Dongbo Mi, Xiaoping Zhang, Xinglei Huanwen Chen and R. Graham Cooks Wang† Jiangxi Key Laboratory for Mass Spectrometry Instrumentation, East China University Technology, Nanchang 330013 , Gao† Su State Inorganic Synthesis Preparative Chemistry, College Jilin University, Changchun 130012 He Cheng Li Mi...
Many cancer vaccines are not successful in clinical trials, mainly due to the challenges associated with breaking immune tolerance. Herein, we report a new strategy using an adjuvant-protein-antigen (three-in-one protein conjugates built-in adjuvant) as anticancer vaccine, which both adjuvant (small-molecule TLR7 agonist) and tumor-associated antigen (mucin 1, MUC1) covalently conjugated same carrier (BSA). It is shown that can increase adjuvant's stimulation, prevent systemic toxicities,...
Exploring potent adjuvants and new vaccine strategies is crucial for the development of protein vaccines. In this work, we synthesized a TLR4 agonist, structurally simplified lipid A analogue GAP112, as built-in adjuvant to improve immunogenicity SARS-CoV-2 spike RBD protein. The agonist GAP112 was site-selectively conjugated on N-terminus construct an adjuvant–protein conjugate in liposomal formulation. It first time that site-specifically quantitatively antigen. Compared with unconjugated...
An efficient N-linked glycosylation reaction between glycosylamines and p-nitrophenyl thioester peptides has been developed. The conditions are mild compatible with the C-terminal free carboxylic acid group unprotected sialyloligosaccharide. By means of this convergent strategy, a versatile N-glycopeptide fragment containing an N-terminal Thz was readily prepared, which is available for synthesis long glycopeptides glycoproteins using protocol native chemical ligation.
Adipic acid diselenoester was developed as an efficient cross-linker for covalent protein conjugation with a variety of small molecular haptens, including mono- and disaccharides, peptide, fluorescence dye, nicotine. Compared to the counterparts N-hydroxysuccinimide (NHS) p-nitrophenyl (PNP) linkers, linker demonstrates improved balance between reactivity stability coupling haptens proteins under mild conditions high incorporation efficiency.
The development of a safe and effective COVID-19 vaccine is paramount importance to terminate the current pandemic. An adjuvant crucial for improving efficacy subunit COVID19 vaccine. α-Galactosylceramide (αGC) classical iNKT cell agonist which causes rapid production Th1- Th2-associated cytokines; we, therefore, expect that or Th2-skewing analogues αGC can better enhance immunogenicity receptor-binding domain in spike protein SARS-CoV-2 fused with Fc region human IgG (RBD-Fc). Herein, we...
Chemical synthesis is an attractive approach allows for the assembly of homogeneous complex N-linked glycopeptides and glycoproteins, but limited coupling efficiency between glycans peptides hampered research in related field. Herein we developed alternative glycosylation to construct glycopeptide via efficient selenoester-assisted aminolysis, which employs peptidyl ω‑asparagine selenoester unprotected glycosylamine perform rapid amide-bond ligation. This strategy highly compatible with free...
Along with N-hydroxysuccinimidyl, p-nitrophenyl, and phenylseleno esters, tetra- penta-fluorophenyl esters were comparatively evaluated in term of their reactivity hydrolytic stability. Their homobifunctional cross-linkers prepared to conjugate proteins small molecules, including carbohydrates, fluorescent dyes, poly(ethylene glycol) monomethyl ether. The conjugations proceeded under mild conditions, affording the corresponding protein conjugates good efficiency.
Adjuvants are essential components of vaccines. Invariant natural killer T (iNKT) cells a distinct subset that function to bridge the innate and adaptive immunities capable mediating strong rapid responses range diseases, including cancer infectious disease. An increasing amount evidence suggests iNKT can help fight viral infection. In particular, iNKT-secreting IL-4 is key mediator humoral immunity has positive correlation with levels neutralizing antibodies. As cell agonists, αGC...
The title compound, [Al(C5H8N2)Cl3], was prepared by a thermolytic decomposition under high-vacuum conditions and presents formal adduct of an Arduengo carbene, 1,3-dimethyl-1H-imidazol-2-yl-idene, aluminium trichloride. Al atom adopts pseudo-tetra-hedral CCl3 coordination environment. All N C atoms, the atom, one Cl all aromatic H atoms mol-ecule lie on mirror plane. As result symmetry mol-ecule, methyl groups are disordered between symmetry-equivalent positions.
A coordinated water dimer leads to a decrease of energy barrier for hydrogen transfer process the highly acidic in 9-fluorenylmethyloxycarbonyl group and promotes its detachment from protected amino acid microdroplets.