A5087312297- Cancer Genomics and Diagnostics
- Computational Drug Discovery Methods
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Biosimilars and Bioanalytical Methods
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Health Systems, Economic Evaluations, Quality of Life
- Protein Degradation and Inhibitors
- Cardiac electrophysiology and arrhythmias
- Cell Image Analysis Techniques
- CAR-T cell therapy research
- Bioinformatics and Genomic Networks
- Click Chemistry and Applications
Frederick National Laboratory for Cancer Research
2022-2023
National Cancer Institute
2023
Abstract The NCI-60 human tumor cell line panel has proved to be a useful tool for the global cancer research community in search novel chemotherapeutics. publicly available characterization and compound screening data from assay have significantly contributed understanding of cellular mechanisms targeted by new oncology agents. Signature sensitivity/resistance patterns generated given chemotherapeutic agent against long served as fingerprint presentations that encompass target information...
<p>Analytical Data</p>
<p>Analytical Data</p>
<p>Figures S1 and S2</p>
<p>Table of GI50 data</p>
<div>Abstract<p>The NCI-60 human tumor cell line panel has proved to be a useful tool for the global cancer research community in search novel chemotherapeutics. The publicly available cell-line characterization and compound screening data from assay have significantly contributed understanding of cellular mechanisms targeted by new oncology agents. Signature sensitivi-ty/resistance patterns generated given chemotherapeutic agent against long served as fingerprint presentations...
<p>Table of GI50 data</p>
<p>Figures S1 and S2</p>
Abstract High-throughput screening (HTS) offers the potential to rapidly evaluate activities of anticancer single agents and combinations in many types cell-based tumor models; however, successful translation findings patients requires models with high biological relevance. The National Cancer Institute’s Patient-Derived Models Repository (PDMR, https://pdmr.cancer.gov) continues develop a collection highly characterized patient-derived organoid representing variety cancer including rare...
Abstract The NCI60 human tumor cell line panel is a useful tool in the discovery and development of new anticancer agents. publicly available cell-line characterization compound screening data from screen have contributed to identifying cellular mechanisms potential Mean-graph sensitivity/resistance patterns serve as fingerprint for molecular target identification mechanism action (MOA). A resource was developed based on 175 FDA-approved oncology drugs (AOD) plus &gt;825 investigational...
<div>Abstract<p>The NCI-60 human tumor cell line panel has proved to be a useful tool for the global cancer research community in search novel chemotherapeutics. The publicly available characterization and compound screening data from assay have significantly contributed understanding of cellular mechanisms targeted by new oncology agents. Signature sensitivity/resistance patterns generated given chemotherapeutic agent against long served as fingerprint presentations that...
<div>Abstract<p>The NCI-60 human tumor cell line panel has proved to be a useful tool for the global cancer research community in search novel chemotherapeutics. The publicly available cell-line characterization and compound screening data from assay have significantly contributed understanding of cellular mechanisms targeted by new oncology agents. Signature sensitivi-ty/resistance patterns generated given chemotherapeutic agent against long served as fingerprint presentations...
<p>Figures S1 and S2</p>
<p>Analytical Data</p>
<p>Figures S1 and S2</p>
<p>Table of GI50 data</p>
<p>Table of GI50 data</p>
<p>Analytical Data</p>
Abstract One of the major challenges in preclinical cancer therapeutic development is establishing physiologically relevant vitro assays that correlate with vivo responses patient tumors to anticancer agents. By incorporating tumor cell heterogeneity and three-dimensional morphological features, patient-derived organoids provide an improved relevancy compared established lines grown as monolayers. However, grow while embedded extracellular matrix material complex media formulations, which...