Acute lung injury (ALI) is the common and complicated inflammatory disease. MicroRNAs (miRNA) have emerged as novel gene regulatory molecules which play a crucial role in multiple diseases, including ALI. In this study, we aims to identify potential functions of miRNA-1246 lipopolysaccharide (LPS)-induced ALI mice, expression effectively up-regulated, compared with control group. overexpression increases inflammation apoptosis vitro model. contrast, knockdown inhibits cell Furthermore,...

Venous thromboembolic events (VTE) is a frequent complication in multiple myeloma (MM) patients, raising mortality. This study aims to use machine learning identify VTE risk factors MM, helping pinpoint high-risk individuals for better clinical management and prognosis. A retrospective analysis was conducted on the basic information, laboratory test results, treatment plans, thrombosis prevention measures of 428 newly diagnosed MM patients at our hospital from December 2018 2022. We used...

Objectives This study aimed to identify the contextual factors of neonatal pain responses and provide clinical medical staff with evidence regarding effective means evaluating strengthen management. Methods Two trained nurses independently used Neonatal Infant Pain Scale (NIPS) assess scores 198 neonates after they underwent painful procedures. Univariate linear regression analysis was performed analyze correlation between NIPS scores. Variables statistically significant differences ( p...

Asthma is a common chronic inflammatory disease involving many different cell types. Recently, type I natural killer T (NKT) cells have been demonstrated to play crucial role in the development of asthma. However, roles II NKT asthma not investigated before. Interestingly, and shown opposing antitumor immunity, antiparasite autoimmunity. We hypothesized that sulfatide-activated could prevent allergic airway inflammation by inhibiting function Strikingly, our mouse model, activation sulfatide...

Invariant natural killer T cells (iNKT cells) are a unique subset of lymphocytes and considered to play an important role in the development allergic bronchial asthma. Recently, iNKT were shown immunoregulatory CD4+ CD8+ cell-mediated adaptive immune response. Allergen-specific Th2 inflammatory responses part response However, regulatory functions asthma have not been studied detail.In this study, we investigated on ovalbumin (OVA)-induced murine model asthma.Our results demonstrate that...

Abstract While over 40 neonatal pain assessment scales have been published, owing to a lack of consensus and standardized metrics, there are more than 100 indicators with varying descriptors quality differences. This study aims reach on optimal comprehensive variables for assessment, leading the development multidimensional response variable set. consisted three phases: (1) A literature review was conducted identify influencing factors response. (2) Panel meetings involving healthcare...

Macrophage phenotype and function varies according to their polarized state, which in turn is dependent on microenvironmental stimuli. Under normal physiological conditions, lung interstitial macrophages that express interleukin (IL)-10 are considered serve regulatory roles the prevention of allergic reactions airways. However, phenotypic profile during pathophysiology asthma remains unknown. In current study, characteristics were investigated an ovalbumin (OVA)-induced mouse model asthma....

To compare the efficacy of theophylline plus salmeterol/fluticasone propionate combination product (SFC) with SFC placebo in asthmatic patients.In this randomized, stratified, parallel-group study, 325 patients were randomized to receive either 200 mg 50/250 μg or tablet twice daily for 24 weeks. Outcome variables included level asthma control (assessed by Asthma Control Test) and number experiencing ≥1 exacerbations during 24-week treatment period. Testing lung function as well measurement...

Panax ginseng is a traditional medicine. Fresh one of the most important industries related to development, and fresh varying ages has different medicinal properties. Previous research not systematically reported correlation between changes in key enzyme activity with ginsenoside content over time. In this study, for first time, we use samples Ji’an seven enzymes (HMGR, FPS, SS, SE, DS, CYP450, GT). We investigated gene expression these enzymes. Ginsenoside was measured using HPLC. HPLC,...

To observe the regulatory effects of RhoA/ROCK pathway on apoptosis cardiac myocyte induced by anoxia and its mechanism.The model was established. The beat pulsations rates after 1 h, 3 6 9 h 12 were recorded expressions RhoA, ROCK1/2, p-PI3K, p-AKT caspae-3 detected, too. related proteins detected RNAi RhoA inhibition ROCK Y-27632.The decreased gradually but increased gradually, caspase-3 increasing along with duration anoxia. apoptotic (4.360.98)%, (8.362.12)%, (15.323.62)%, (18.684.83)%...

Non-small-cell lung cancer (NSCLC) accounts for more than half of all cases. Cytokines play an important role in NSCLC, including IL-27. IL-27 inhibits NSCLC progression; however, the mechanism is not clear. The purpose this study to investigate effects on cell proliferation and metastasis.NSCLC cells were treated with or transfected miR-935, was assayed by Cell Counting Kit-8 (CCK-8) colony formation. metastasis analyzed Transwell chamber system wound healing assay. protein medium ELISA....

Glutathione peroxidase (GPx) is an antioxidant protein containing selenium. Owing to the limitations of native GPx, considerable efforts have been made develop GPx mimics. Here, a short 5-mer peptides (5P) was synthesized and characterized using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Enzyme coupled assays were used evaluate activity. The cell viability apoptosis H22 cells tested, mice bearing cell-derived tumors determine effects 5P on tumor inhibition....

Our previous study showed that invariant natural killer T (iNKT) cells might act as an adjuvant to promote Th2 inflammatory responses in OVA-induced mouse model of allergic asthma, but the mechanism remains unknown. To clarify underlying through which iNKT responses, we investigated modulatory influence on phenotypic and functional maturation lung dendritic (LDCs) using cell-knockout mice, specific cell activation, coculture experiments, adoptive transfer models asthma. data deficiency could...

Asthma is a common inflammatory pulmonary disorder involving diverse array of immune cells such as proinflammatory T helper 2 (Th2) cells. We recently reported that intraperitoneal injection α-galactosylceramide (α-GalCer) can stimulate the lung invariant natural killer (iNKT) and does not lead to airway inflammation in WT mice. Other studies indicate iNKT play an important role inducing regulatory (Treg cells) peripheral tolerance. Using cell- knockout mice, functional inactivation Treg...

In order to overcome the instability of natural glutathione peroxidase (GPx), scientists endeavor produce GPx mimics. The popular method first uses biological imprinting (BI) substrate binding sites and then employs chemical mutation (CM) obtain catalytic site. However, BICM has a drawback in that site is not clear. Some researchers therefore tried change method. These new mimics were prepared by producing through mutation, employing (CMBI). It clear site, but its determination enzyme...

Abstract Our previous study showed that intraperitoneal injection of α‐galactosylceramide (α‐GalCer) has the ability to activate lung iNKT cells, but α‐GalCer‐activated cells do not result in airway inflammation wild‐type ( WT ) mice. Many studies had capacity induce Treg which gave rise peripheral tolerance. Therefore, we examined influence administration α‐GalCer on expansion and suppressive activity using cell‐knockout mice co‐culture experiments vitro. We also compared...

The correlation of gene expressions HMGR and DS with total ginsenoside content was significant.

Despite the success of text-to-text pre-trained models in various natural language generation (NLG) tasks, performance is largely restricted by number labeled data downstream particularly data-to-text tasks. Existing works mostly utilize abundant unlabeled structured to conduct unsupervised pre-training for task adaption, which fail model complex relationship between source and target texts. Thus, we introduce self-training as a better few-shot learner than task-adaptive pre-training,...

<title>Abstract</title> Purpose While over 40 neonatal pain assessment scales have been published, owing to lack of consensus and standardized metrics, there are more than 100 indicators with varying descriptors quality differences. This study aims reach on optimal comprehensive variables for assessment, leading develop a multi-dimensional response variable set. Method consisted three phases: (1) A literature review was conducted identify influencing factors response. (2) Panel meeting...

Pre-trained language models (PLMs) are proficient at understanding context in plain text but often struggle with the nuanced linguistics of task-oriented dialogues. The information exchanges dialogues and dynamic role-shifting speakers contribute to complex coreference interlinking phenomena across multi-turn interactions. To address these challenges, we propose Coreference-Enhanced Contrastive Pre-training (CECPT), an innovative pre-training framework specifically designed enhance dialogue...