A5048105406- Glioma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Polysaccharides Composition and Applications
- Molecular Sensors and Ion Detection
- Congenital Anomalies and Fetal Surgery
- Blind Source Separation Techniques
- Phagocytosis and Immune Regulation
- Wine Industry and Tourism
- Bioactive Compounds and Antitumor Agents
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Plant responses to elevated CO2
- Crop Yield and Soil Fertility
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- PI3K/AKT/mTOR signaling in cancer
- Food composition and properties
- Bioactive natural compounds
- Drug Solubulity and Delivery Systems
- Food Supply Chain Traceability
- Metal complexes synthesis and properties
- Atmospheric chemistry and aerosols
Hebei Agricultural University
2023-2025
Dalian Medical University
2025
Hangzhou Dianzi University
2024
Guangdong Medical College
2023-2024
Tsinghua University
2023
Wenzhou Medical University
2023
State Key Laboratory of Molecular Oncology
2023
Northeast Agricultural University
2021
Heilongjiang University of Chinese Medicine
2018
Chronic hepatitis B (CHB) is a common cause of liver cirrhosis (LC), condition associated with an unfavourable prognosis. Therefore, timely diagnosis LC in CHB patients crucial. This study aimed to enhance the diagnostic accuracy by integrating stiffness measurement (LSM) traditional indicators. The participants were randomly divided into training and internal validation sets. Employing least absolute shrinkage selection operator (LASSO) random forest-recursive feature elimination (RF-RFE)...
China's pet industry is experiencing robust growth, prompting this research to develop a series of innovative forecasting models that not only predict the future number pets and size food market in China globally but also offer practical suggestions for expansion. A key innovation lies integration Grey Model GM(1,1) forecast population with high precision, coupled correlation analysis pinpoint critical factors driving development. Furthermore, study employs ARIMA model global demand trends...
Late-season foliar nitrogen (N) application is widely employed to improve wheat grain yield and protein concentration, particularly during later growth stages when root activity declines N uptake becomes less efficient. However, the reported effects of on quality remain inconsistent. This meta-analysis, based 51 field trials encompassing 1498 observations, quantitatively evaluates impact late-season concentration. The results demonstrate that significantly enhances both (+4.1%) concentration...
Abstract Diffuse intrinsic pontine glioma (DIPG) is the most aggressive pediatric brain tumor, and oncohistone H3.3K27M mutation associated with significantly worse clinical outcomes. Despite extensive research efforts, effective approaches for treating DIPG are lacking. Through drug screening, we identified combination of gemcitabine fimepinostat as a potent therapeutic intervention DIPG. facilitated gemcitabine-induced apoptosis in DIPG, stabilized activated p53, including increasing...
Safflower polysaccharide (SPS) is a major active component of Carthamus tinctorius L. Previous reports have demonstrated that SPS shows cytotoxic activity against various types cancer cells; however, its anti-cervical effect remains unclear. Therefore, we explored the treatment cervical cell line (HeLa). significantly inhibited proliferation and increased rate apoptosis as determined by TdT-mediated dUTP nick-end labeling assay, Hoechst 33342 staining, double staining with annexin...
Group A rotaviruses (RVAs) are major enteric pathogens causing infections in calves. To investigate the epidemiological characteristics and genetic diversity of bovine rotavirus (BRV), 233 fecal samples were collected from calves with diarrhea northeast China. The analyzed for sequences encoding inner capsid protein VP6 (subgroup) outer proteins VP7 VP4 (G P type, respectively) using RT-PCR. Ten (4.3%) identified as BRV positive used virus isolation sequence analysis, revealing that all...
Late stage nitrogen (N) applications following basic fertilization are commonly used to ensure grain yield and increase protein content in wheat. Split N at the late growth of wheat an effective measure improve absorption transport thus content. However, whether split can alleviate decrease induced by elevated atmospheric CO2 concentrations (e[CO2]) remains unclear. In present study, a free-air enrichment system was investigate effects (at booting or anthesis) on yield, utilization, content,...
<div>Abstract<p>Diffuse intrinsic pontine glioma (DIPG) is the most aggressive pediatric brain tumor, and oncohistone H3.3K27M mutation associated with significantly worse clinical outcomes. Despite extensive research efforts, effective approaches for treating DIPG are lacking. Through drug screening, we identified combination of gemcitabine fimepinostat as a potent therapeutic intervention DIPG. facilitated gemcitabine-induced apoptosis in DIPG, stabilized activated p53,...
<p>Supplementary Figures 1-7; Supplementary Tables 1-8</p>
<p>Supplementary Figures 1-7; Supplementary Tables 1-8</p>
<div>Abstract<p>Diffuse intrinsic pontine glioma (DIPG) is the most aggressive pediatric brain tumor, and oncohistone H3.3K27M mutation associated with significantly worse clinical outcomes. Despite extensive research efforts, effective approaches for treating DIPG are lacking. Through drug screening, we identified combination of gemcitabine fimepinostat as a potent therapeutic intervention DIPG. facilitated gemcitabine-induced apoptosis in DIPG, stabilized activated p53,...
Abstract Mitochondrial viscosity has emerged as a promising biomarker for diseases such cancer and neurodegenerative disorders, yet accurately measuring at the subcellular level remains significant challenge. In this study, we synthesized characterized three cyclometalated iridium(III) complexes ( Ir1‐Ir3 ) containing 5‐fluorouracil derivatives ligands. Among these, Ir1 selectively induced apoptosis in HeLa cells by increasing mitochondrial production of reactive oxygen species (ROS), which...