A5025792959- Salmonella and Campylobacter epidemiology
- Vibrio bacteria research studies
- Bacteriophages and microbial interactions
- CRISPR and Genetic Engineering
- Genomics and Phylogenetic Studies
- Evolution and Genetic Dynamics
- Bacterial Genetics and Biotechnology
- Insect symbiosis and bacterial influences
- Microbial infections and disease research
- Cytomegalovirus and herpesvirus research
- Antibiotic Resistance in Bacteria
- Viral gastroenteritis research and epidemiology
University of Southampton
2022-2024
Birla Institute of Technology and Science, Pilani
2020-2024
Bacterial defense against phage predation involves diverse systems acting individually and concurrently, yet their interactions remain poorly understood. We investigated >100 in 42,925 bacterial genomes identified numerous instances of non-random co-occurrence negative association. For several pairs significantly co-occurring Escherichia coli strains, we demonstrate synergistic anti-phage activity. Notably, Zorya II synergizes with Druantia III ietAS systems, while tmn exhibits synergy...
Understanding the dynamic evolution of Salmonella is vital for effective bacterial infection management. This study explores role flexible genome, organised in regions genomic plasticity (RGP), shaping pathogenicity lineages. Through comprehensive analysis 12,244 spp. genomes covering 2 species, 6 subspecies, and 46 serovars, we uncover distinct integration patterns pathogenicity-related gene clusters into RGP, challenging traditional views distribution. These RGP exhibit preferences...
ABSTRACT Bacterial defence against phage predation involves diverse systems acting both individually and concurrently, yet their interactions remain poorly understood. We investigated >100 in 42,925 bacterial genomes identified numerous instances of non-random co-occurrence mutual exclusion. For several pairs significantly co-occurring Escherichia coli strains, we demonstrate synergistic anti-phage activity, including tmn synergising with containing sensory switch ATPase domains. Some the...
Abstract Salmonellae display intricate evolutionary patterns comprising over 2500 serovars having diverse pathogenic profiles. The acquisition and/or exchange of various virulence factors influences the framework. To gain insights into evolution Salmonella in association with CRISPR-Cas genes we performed phylogenetic surveillance across strains 22 serovars. differed their CRISPR1-leader and cas operon features assorting two main clades, CRISPR1-STY/ -STY CRISPR1-STM/ -STM, majorly typhoidal...
The growing threat of multidrug-resistant Klebsiella pneumoniae, coupled with its role in gut colonisation, has intensified the search for new treatments, including bacteriophage therapy. Despite increasing documentation Klebsiella-targeting phages, clinical applications remain limited, key phage-bacteria interactions still poorly understood. A major obstacle is fragmented access to well-characterised pairings, restricting collective advancement therapeutic and mechanistic insights. To...
Enterotoxigenic
Abstract The flexible genome, organised in regions of genomic plasticity (RGP), serves as a potent facilitator the dynamic evolution bacterial genomes through gene acquisition and loss. Here we explored across Salmonella lineages, revealing purposeful, non-random integration pattern pathogenicity-related clusters into specific RGP. Noteworthy examples include correlation between type I-E CRISPR-Cas system, gold tolerance, scattered prevalence RGP lineages profoundly shapes pathogenicity...
Abstract Salmonellae display intricate evolutionary patterns comprising over 2500 serovars having diverse pathogenic profiles. The acquisition/exchange of various virulence factors influence the framework. To gain insights into evolution Salmonella as a pathogen in association with CRISPR-Cas genes we performed phylogenetic surveillance across strains 22 serovars. assorted two main clades, pertaining to differences their CRISPR1-leader and cas operon. Considering enterica subsp. serovar...