A5048710481- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Cervical Cancer and HPV Research
- Bacteriophages and microbial interactions
- Microbial infections and disease research
- Genomics and Phylogenetic Studies
- Immune Cell Function and Interaction
- Exercise and Physiological Responses
- Cancer-related molecular mechanisms research
- Multiple and Secondary Primary Cancers
- Testicular diseases and treatments
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Acute Lymphoblastic Leukemia research
- Gut microbiota and health
- Hematopoietic Stem Cell Transplantation
- Epigenetics and DNA Methylation
- Multiple Myeloma Research and Treatments
- Toxin Mechanisms and Immunotoxins
- Erythrocyte Function and Pathophysiology
- Endometrial and Cervical Cancer Treatments
- Lymphatic System and Diseases
- Probiotics and Fermented Foods
- Complement system in diseases
University of Southampton
2022-2024
University of Bath
2024
University of Kent
2020-2022
Human papillomavirus (HPV)-associated cervical cancer is a leading cause of deaths in women. Here we present an integrated multi-omic analysis 643 squamous cell carcinomas (CSCC, the most common histological variant cancer), representing patient populations from USA, Europe and Sub-Saharan Africa identify two CSCC subtypes (C1 C2) with differing prognosis. C1 C2 tumours can be driven by either HPV types (16 18) while HPV16 HPV18 are overrepresented among respectively, prognostic difference...
Abstract Background High levels of physical activity are associated with reduced risk the blood cancer multiple myeloma (MM). MM is preceded by asymptomatic stages monoclonal gammopathy undetermined significance (MGUS) and smouldering (SMM) which clinically managed watchful waiting. A case study ( N = 1) a former elite athlete aged 44 years previously indicated that multi-modal exercise programme reversed SMM disease activity. To build from this prior study, present pilot firstly examined if...
Chronic lymphocytic leukaemia (CLL) is characterised by the clonal proliferation and accumulation of mature B-cells often treated with rituximab, an anti-CD20 monoclonal antibody immunotherapy. Rituximab fails to induce stringent disease eradication, due in part failure antibody-dependent cellular cytotoxicity which relies on natural killer (NK)-cells binding rituximab-bound CD20 B-cells. CLL cells are diffusely spread across lymphoid other bodily tissues, ADCC resistance survival niches may...
The growing threat of multidrug-resistant Klebsiella pneumoniae, coupled with its role in gut colonisation, has intensified the search for new treatments, including bacteriophage therapy. Despite increasing documentation Klebsiella-targeting phages, clinical applications remain limited, key phage-bacteria interactions still poorly understood. A major obstacle is fragmented access to well-characterised pairings, restricting collective advancement therapeutic and mechanistic insights. To...
Chronic lymphocytic leukaemia (CLL) typically presents with asymptomatic, early-stage disease that is monitored until progression ('treatment-naïve' CLL). The objective of this pilot study was to assess the feasibility and preliminary safety an exercise program in treatment-naïve CLL. We also sought preliminarily impact on activity, as it has been proposed training may reduce outgrowth
Abstract Complement-dependent cytotoxicity (CDC) is a primary mechanism-of-action of monoclonal antibody (mAb) immunotherapies used to treat haematological cancers, including rituximab and daratumumab. However, mAb efficacy may be limited by reduced bioavailability complement C1q – which activates the classical pathway following interactions with mAb-opsonised target cells. secreted phagocytes upon recruitment sites muscle damage facilitate muscular repair, hence we hypothesised that...
Abstract Human papillomavirus (HPV)-associated cervical cancer represents one of the leading causes death worldwide. Although low-middle income countries are disproportionately affected, our knowledge disease predominantly originates from populations in high-income countries. Using largest multi-omic analysis squamous cell carcinoma (CSCC) to date, totalling 643 tumours and representing patient USA, Europe Sub-Saharan Africa, we identify two CSCC subtypes (C1 C2) with differing prognosis. C1...
Abstract Human papillomavirus (HPV)-associated cervical cancer represents one of the leading causes death worldwide. Although low-middle income countries are disproportionately affected, our knowledge disease predominantly originates from populations in high-income countries. Using largest multi-omic analysis squamous cell carcinoma (CSCC) to date, totalling 643 tumours and representing patient USA, Europe Sub-Saharan Africa, we identify two CSCC subtypes (C1 C2) with differing prognosis. C1...