A5021619553- Bacterial Genetics and Biotechnology
- Salmonella and Campylobacter epidemiology
- RNA and protein synthesis mechanisms
- bioluminescence and chemiluminescence research
- Cytomegalovirus and herpesvirus research
- Bacteriophages and microbial interactions
- Tuberculosis Research and Epidemiology
- Antibiotic Resistance in Bacteria
- HIV Research and Treatment
- Gut microbiota and health
- Vibrio bacteria research studies
- Fecal contamination and water quality
- HIV/AIDS drug development and treatment
- Microbial Natural Products and Biosynthesis
- Pneumocystis jirovecii pneumonia detection and treatment
- Herpesvirus Infections and Treatments
- Listeria monocytogenes in Food Safety
- Child Nutrition and Water Access
- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Mycobacterium research and diagnosis
University of British Columbia
2015-2020
Canada's Michael Smith Genome Sciences Centre
2015-2020
Centre d’études d’agents Pathogènes et Biotechnologies Pour la Santé
2009-2010
Université de Montpellier
2009-2010
Centre National de la Recherche Scientifique
2009-2010
Institut Mondor de Recherche Biomédicale
2010
The pathogenesis of Salmonella Typhimurium depends on the bacterium's ability to survive and replicate within host cells. formation maintenance a unique membrane-bound compartment, termed Salmonella-containing vacuole (SCV), is essential for S. pathogenesis. SCV-bound induces filamentous tubules that radiate outwards from SCV, Salmonella-induced filaments (SIFs). SIF concomitant with onset replication epithelial biogenesis, intracellular positioning SCV cell requires translocation bacterial...
Numerous cellular factors belonging to the DNA repair machineries, including RAD18, RAD52, XPB and XPD, have been described counteract human immunodeficiency virus type 1 (HIV-1) replication. Recently, Uracil glycosylase 2 (UNG2), a major determinant of uracil base excision pathway, was shown undergo rapid proteasome-dependent degradation following HIV-1 infection. However, specific role intracellular UNG2 depletion during course infection is not clearly understood. Our study shows for first...
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a foodborne enteric pathogen and major cause of gastroenteritis in humans. It known that molecules derived from the human fecal microbiota downregulate S. virulence gene expression induce starvation-like response. In this study, was cultured minimal media to mimic starvation conditions such as experienced by intestinal tract, pathogen's vitro vivo measured. displayed reduced ability invade epithelial cells manner at least partially...
Evaluation of: Belogurov GA, Vassylyeva MN, Sevostyanova A et al.: Transcription inactivation through local refolding of the RNA polymerase structure. Nature 457, 332–335 (2008) and, Mukhopadhyay J, Das K, Ismail S The 'switch region' is a target for inhibitors. Cell 135, 295–307 (2008). Bacterial an essential enzyme, which responsible synthesizing from DNA template and targeted by number antibiotics. mechanism action two closely related transcription inhibitors, myxopyronin B synthetic...
The redox balance in a variety of Gram-negative bacteria was explored using sensitive GFP (roGFP2), J. van der Heijden et al. doi:10.1016/j.freeradbiomed.2015.11.029 [1]. This data article provides Supporting material to further investigate the relationship between Salmonella typhimurium survival and oxidative stress. first set presented this article, shows percentage surviving after exposure hydrogen peroxide. second concentration peroxide that produced by S. Typhimurium different growth...
Numerous cellular factors belonging to the DNA repair machineries, including RAD18, RAD52, XPB and XPD, have been described counteract human immunodeficiency virus type 1 (HIV-1) replication. Recently, Uracil glycosylase 2 (UNG2), a major determinant of uracil base excision pathway, was shown undergo rapid proteasome-dependent degradation following HIV-1 infection. However, specific role intracellular UNG2 depletion during course infection is not clearly understood. Our study shows for first...