A5063202763- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Hemophilia Treatment and Research
- Blood groups and transfusion
- Blood donation and transfusion practices
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Child Nutrition and Water Access
- Erythrocyte Function and Pathophysiology
- Blood Coagulation and Thrombosis Mechanisms
- Bone and Joint Diseases
- Malaria Research and Control
- Prenatal Screening and Diagnostics
- Breastfeeding Practices and Influences
- Hematological disorders and diagnostics
- Neonatal Health and Biochemistry
- Blood properties and coagulation
- Child and Adolescent Health
- Platelet Disorders and Treatments
- Global Maternal and Child Health
- Erythropoietin and Anemia Treatment
- Cardiac Valve Diseases and Treatments
- Bird parasitology and diseases
- Syphilis Diagnosis and Treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Abdominal vascular conditions and treatments
Bayero University Kano
2017-2024
Aminu Kano Teaching Hospital
2015-2024
Usmanu Danfodiyo University Teaching Hospital, Sokoto
2021
University of Maiduguri
2000-2017
In a retrospective analysis, the quantities, patterns and adequacy of blood donations made, between 1984 2006, at University Maiduguri Teaching Hospital in north–eastern Nigeria were explored related to safety study area. The types donor reviewed annual increments number made estimated compared with numbers in-patients managed hospital. mean increment (4%) fell well below in-patient (11%). received hospital into four types: voluntary, family-replacement, commercial pre-deposit autologous...
Introduction Sickle cell disease (SCD) is the most common hemoglobinopathy in world. Over 90% of those born with SCD live low- and middle-income countries (LMICs), yet individuals these settings have much poorer outcomes compared to high-income countries.Areas Covered This manuscript provides an in-depth review cornerstones basic care, barriers implementing LMICs, strategies increase access regions. Publications English language, peer-reviewed, edited from 2000 2021 were identified on...
Aim: A ten – year retrospective study was conducted with the aim to determine prevalence of Newcastle Disease (ND) in relation other poultry diseases diagnosed State area veterinary clinics. Study Design: Retrospective study. Place and Duration Study: This Gombe State, Northeastern Nigeria. Case files from Tashan Dukku Pantami clinics metropolis were reviewed for File cases reported between January 2004 December 2013 studied. Original Research Article Lawal et al.; BMRJ, 6(6): 367-375, 2015;...
Sickle cell disease (SCD) is characterized by recurrent vaso-occlusive crisis (VOC). VOC an important index of severity and has been shown to correlate with the risk multi-organ damage early death. Although vulnerability among patients SCD may be genetically predetermined on basis genotype haplotype variability, nonetheless, usually triggered a wide spectrum etiologic factors, which range from physiological nonphysiological factors one hand, psychological physical other hand. An...
Priapism was associated with certain hematological parameters in sickle cell anemia (SCA) patients one report but not another. We studied differences haematological between SCA and without priapism.Eighteen who presented acute priapism during the years 2001-2004 were compared age- sex-matched respect to hematocrit, reticulocyte count, level of irreversibly sickled cells (ISC), percentage haemoglobin F (Hb F), total leukocyte platelet counts.SCA had a mean hematocrit 0.28 L/L, which...
In high-income countries, premarital genetic counseling for Sickle Cell Disease (SCD) is a standard practice. However, in Nigeria, there no formal program available SCD. We conducted series of focus group discussions with health care professionals, patients SCD, and parents the or without SCD to gain an understanding their attitudes beliefs towards SCD/Sickle Trait Data were analyzed using Charmaz’s constructivist grounded theory approach. Two themes highlighted analysis as follows: (1)...
Background: Determining the antimicrobial sensitivity pattern of urinary tract infection (UTI) in malnourished children a community will help clinician decision-making regarding suitable first-line antibiotics. Materials and Methods: We performed prospective cross-sectional study from July to November 2011 at Aminu Kano Teaching Hospital determine prevalence UTI evaluate antibiotic organisms isolated urine with protein-energy malnutrition (PEM) normal controls. In total, 169 PEM aged 6–59...
The non-O blood group is an established risk factor for deep vein thrombosis (DVT), while controversy surrounds the role of sickle cell trait (SCT) as a DVT. We hypothesised that if SCT DVT, individuals with groups and (Hb AS) would have higher DVT than their counterparts normal haemoglobin phenotype AA).We retrospectively analysed prevalence among 148 patients control subjects in order to determine its impact on groups.In comparison subjects, had significantly prevalences (35.1% vs 27.7%,...
Background Haemophilia-A (HA) is an X-linked recessive disorder characterized by the deficiency of functional clotting factor VIII resulting in lifelong bleeding diathesis. We predict that HA would be associated with iron and risk will higher those severe disease. If our prediction correct, frequency relative (RR) patients comparison nonsevere HA. Materials methods evaluated levels haemoglobin concentrations, red cell indices serum ferritin retrospectively respect to disease severity among a...
This study was conducted to evaluate the burden of HIV/AIDS on blood bank reserves at University Maiduguri Teaching Hospital, Nigeria, during 1995-2005. The number admissions due rose from 43 in 1995 447 2005, and proportion units used transfusing patients with steadily 3% 19% 2005. managing obstetric also high fluctuated between 36% 50% period study. Controlling spread HIV, effective treatment antiretroviral drugs setting up a functional national transfusion service could lessen rising...
Background Sickle cell disease (SCD) patients have impaired immunity with vulnerability to infections including parasitic infestations. Majority of SCD live in nations where urinary schistosomiasis is also endemic. This study was aimed at determining the impact on haematological parameters and frequency vaso-occlusive crisis (VOC) among SCD. Materials Methods We compared VOC without northern Nigeria. Result had lower haematocrit, higher reticulocyte count, prevalence iron deficiency, more...
Background In sickle cell disease (SCD), the vascular endothelium is in a continuous state of activation by inflammatory cytokines, leading to increased secretion von Willebrand factor (vWF), which potent mediator cytoadherence. Vaso-occlusive crisis (VOC) involves cytoadherence red cells, leucocytes and platelets onto endothelium. Non-O blood groups are also associated with elevation vWF levels. Thus, SCD non-O independently elevated levels vWF, an important cofactor pathogenesis VOC....
Abstract Haemophilia A is an X-linked recessive disorder associated with deficiency of coagulation factor VIII and lifelong bleeding diathesis. Sickle cell trait (SCT) the heterozygous state for sickle β -globin gene. The frequency SCT up to 30% in Africa, wherein it confers survival advantage by providing resistance against severe malaria. does not cause vaso-occlusive crisis, but high risk venous thromboembolism as variously reported literature. We consider a hypercoagulable prothrombotic...
Abstract We predicted that haemophilia would create a prohaemorrhagic host-parasite relationship, which make haemophiliacs very vulnerable to haemorrhagic effects of intestinal helminths in tropical countries like Nigeria. If our prediction is correct, the frequency and risks gastrointestinal haemorrhage iron deficiency will be higher among infected by comparison with uninfected haemophiliacs. Frequency haemorrhages without helminth infections were retrospectively obtained analysed, their...
Haemophilia-A is characterized by deficiency of FVIII, but the bleeding diathesis not a mere reflection low FVIII activity. The pathophysiology haemophilic complex interplay between defective procoagulant function and up-regulated fibrinolysis. Moreover, frequently compounded treatment-related infective complications such as inhibitors, hepatitis, HIV infection, non-steroidal anti-inflammatory drugs (NSAID) induced gastritis, mucosal injuries H pylori gastritis intestinal urinary...
Abstract Haematuria is not uncommon in people with haemophilia and mainly caused by spontaneous haemorrhage or trauma. The frequency clinical significance of urinary schistosomiasis the aetiology haematuria among haemophiliacs endemic countries such as Nigeria have been previously studied. We retrospectively analysed laboratory data 45 aim determining other causes haemophiliacs, haematological profiles severity schistosomal relative to non-schistosomal haematuria. was due 23 (51.1%)...
Acute Chest Syndrome (ACS) is a major cause of hospitalisation, potentially life-threatening complication and leading mortality in children with Sickle Cell Disease (SCD). The affected child commonly presents respiratory symptoms such as cough, breathlessness, chest pain, jitteriness, confusion, or without fever. this condition multifactorial sometimes unidentified, but the majority are due to infection, infarction, fat embolism. ACS its related complications may be minimised by prompt...
Newborn screening for sickle cell disease (SCD) is sparse in sub-Saharan Africa. The leadership of the Aminu Kano Teaching Hospital (AKTH) Kano, Nigeria, with support local religious authorities, established a groundbreaking SCD newborn program that has become standard care pregnant women and their newborns. Our includes (1) prenatal genetic counseling all antenatal clinic, (2) screening, (3) postnatal parents newborns diagnosed SCT, (4) referral follow-up Comprehensive Care Clinic by 3...
In pyopericardium, pus accumulates in the pericardial space as a result of infection by pyogenic organisms, most common which are Staphylococcus aureus and Mycobacterium tuberculosis. These patients at risk cardiac tamponade. Apart from pericardiocentesis management these patients, definitive drug treatment may pose formidable challenge setting coinfection with tuberculosis who predisposed to secondary bacterial infections. This was case our patient. We here highlight challenges faced...