A5039231699- Chromosomal and Genetic Variations
- Renal and related cancers
- Aldose Reductase and Taurine
- CRISPR and Genetic Engineering
- Intensive Care Unit Cognitive Disorders
- Plant Virus Research Studies
- Animal Virus Infections Studies
- Electrolyte and hormonal disorders
- Genomics and Phylogenetic Studies
- Cytomegalovirus and herpesvirus research
- Chronic Kidney Disease and Diabetes
- Heme Oxygenase-1 and Carbon Monoxide
- Viral-associated cancers and disorders
- Geriatric Care and Nursing Homes
- Occupational Therapy Practice and Research
- RNA and protein synthesis mechanisms
- Birth, Development, and Health
- Social and Educational Sciences
- T-cell and Retrovirus Studies
- Ubiquitin and proteasome pathways
- Polyomavirus and related diseases
- Neuroblastoma Research and Treatments
- Ion Transport and Channel Regulation
Martin Luther University Halle-Wittenberg
2019-2025
Luther University
2020
Linköping University Hospital
2006
Abstract Nuclear factor of activated T‐cells 5 (NFAT5) is a transcription known for its role in osmotic stress adaptation the renal inner medulla, due to gradient that generated between cortex and medulla. However, broader implications kidney injury chronic disease (CKD) are less understood. Here we used two different Cre deleter mice (Ksp1.3‐Cre Aqp2‐Cre) generate tubule segment even cell type‐specific NFAT5‐deficient performed extensive gene expression profiling. In both Nfat5 knockout...
The immune pathogenesis of multiple sclerosis (MS) is thought to be triggered by environmental factors in individuals with an unfavorable genetic predisposition. Epstein-Barr virus (EBV) infection a major risk factor for subsequent development MS. Human endogenous retroviruses (HERVs) can activated EBV, and might missing link between initial EBV the later onset In this study, we investigated differential gene expression patterns EBV-immortalized lymphoblastoid B cell lines (LCL) from...
Endogenous retroviruses (ERVs) are becoming more and relevant in cancer research might be potential targets. The oncogenic of human ERVs (HERVs) has been recognized includes immunosuppression, cell fusion, antigenicity viral proteins, regulation neighboring genes. To decipher the role HERVs cancers, we used a bioinformatics approach analyzed RNA sequencing data from LL-100 panel, covering 22 entities hematopoietic neoplasias including T cell, B myeloid malignancies. We compared HERV...
The aim was to evaluate whether occupational therapy interventions in acute care could improve the elderly patient's perception of ability manage at home after discharge. A pilot study performed, including 22 patients experimental group and 19 control group. Occupational were conducted concerning personal care, information, prescription assistive devices, planning discharge, reporting primary or community care. given no interventions. Structured interviews performed on discharge a follow-up...
During characterization of a cDNA library from the Hodgkin lymphoma (HL) cell line L-1236, we discovered new transcript derived chromosome 1 at long intergenic non-protein coding RNA 1768 (LINC01768)/colony stimulating factor (CSF1) region. The first exon this cells (THOLE) starts in predicted 4 LINC01768 and is part an endogenous retrovirus (ERV) HUERS-P1/LTR8 family. High expression THOLE was only detectable HL L-1236. L-1236 another example for ERV/LTR-associated gene cells. At genome...
ABSTRACT A spatial gene expression pattern between the cortex (CTX) and inner medulla (IM) of kidney has been observed, but underlying mechanisms are unclear. Understanding these is essential for elucidating renal function. Using Assay Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq) we analyzed open chromatin structures involvement epigenetic in mediating differences CTX IM. We also examined role nuclear factor activated T cells 5 (NFAT5), a key regulator...
Introduction: The osmotic gradient between renal cortex (CTX) and inner medulla (IM) is important for the generation of a concentrated urine. In addition, unique hypertonic environment in IM induces specific gene expression pattern. For example aquaporin-2 (Aqp2) enriched compared to CTX. We postulated that these changes must be associated with epigenetic mechanisms could regulate spatial pattern CTX IM. performed assay transposase-accessible chromatin (ATAC) sequencing identify genomic...
Neuroblastoma (NB) is the commonest solid tumor outside central nervous system in infancy and childhood with a unique biological heterogeneity. In patients advanced, metastasizing neuroblastoma, treatment failure poor prognosis often marked by resistance to chemo- or immunotherapy. Thus, identification of robust biomarkers seems essential for understanding progression developing effective therapy. Here, we have studied expression human endogenous retroviruses (HERV) as potential targets NB...
Introduction During human evolution, germline infections by retroviruses have repeatedly occurred, integrating viral DNA into the host genome. As a result, genome consists of approximately 8% endogenous (HERV). Although most this is defective due to mutations, there are sequences with intact open reading frames for generation transcripts and proteins. In Hodgkin lymphoma (HL) activation HERV loci expression related has been observed.