A5033717096- Metabolomics and Mass Spectrometry Studies
- Lysosomal Storage Disorders Research
- COVID-19 Impact on Reproduction
- Glycosylation and Glycoproteins Research
- Diet and metabolism studies
- Pregnancy and preeclampsia studies
- COVID-19 and healthcare impacts
- Biochemical and biochemical processes
- Oral microbiology and periodontitis research
- Infectious Encephalopathies and Encephalitis
- Parkinson's Disease Mechanisms and Treatments
- Computational Drug Discovery Methods
- Metabolism and Genetic Disorders
- Free Radicals and Antioxidants
- Chemical Reaction Mechanisms
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- Glycogen Storage Diseases and Myoclonus
- Curcumin's Biomedical Applications
- Liver Disease Diagnosis and Treatment
Universidade Federal do Rio de Janeiro
2022-2024
Universidade Federal Fluminense
2023
This review article compiles critical pre-analytical factors for sample collection and extraction of eight uncommon or underexplored biological specimens (human breast milk, ocular fluids, sebum, seminal plasma, sweat, hair, saliva, cerebrospinal fluid) under the perspective clinical metabolomics. These samples are interesting metabolomics studies as they reflect status living organisms can be applied diagnostic purposes biomarker discovery. Pre-collection procedures critical, requiring...
Brazil has the second-highest COVID-19 death rate worldwide, and Rio de Janeiro is among states with highest in country. Although vaccine coverage been achieved, it anticipated that will transition into an endemic disease. It concerning molecular mechanisms underlying clinical evolution from mild to severe disease, as well leading long COVID-19, are not yet fully understood. NMR MS-based metabolomics were used identify metabolites associated pathophysiology disease outcome. Severe cases (n =...
Esters are one of the major functional groups present in structures prodrugs and bioactive compounds. Their presence is often associated with hydrolytic lability. In this paper, we describe a comparative chemical biological stability homologous esters isosteres base media as well rat plasma liver microsomes. Our results provided evidence for structure lability relationship demonstrated that microsome might depend on carboxylesterase activity. Molecular modelling studies were performed order...
Pompe disease (PD) is an inborn error of metabolism caused by α-glucosidase acid enzyme deficiency. It significantly impacts patients' health and life quality may lead to death in the first few years life. Among well-established diagnostic methods, urinary glucose tetrasaccharide (Glc4) screening high performance-liquid chromatography has been helpful monitoring Glc4 levels patients on replacement therapy, demonstrating therapy efficacy. However, specimen shipping process from a sample...
Abstract Brazil has the second highest COVID-19 death rate while Rio de Janeiro is among states with in country. Although effective vaccines have been developed, it anticipated that ongoing pandemic will transition into an endemic state. Under this scenario, worrisome underlying molecular mechanisms associated disease clinical evolution from mild to severe, as well leading long COVID are not yet fully understood. In study, 1 H Nuclear Magnetic Resonance spectroscopy and Liquid...