A5113434115- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Genomics and Chromatin Dynamics
- Genomics and Rare Diseases
- Genomic variations and chromosomal abnormalities
- Virus-based gene therapy research
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
Shanghai East Hospital
2023-2024
Jinggangshan University
2023-2024
Abstract Topologically associating domain (TAD) reorganization commonly occurs in the cell nucleus and contributes to gene activation inhibition through separation or fusion of adjacent TADs. However, functional genes impacted by TAD alteration underlying mechanism regulating transcription remain be fully elucidated. Here, we first developed a novel approach termed Inter3D specifically identify regulated reorganization. Our study revealed that segregation TADs led disruption intrachromosomal...
Abstract Multiple gene abnormalities are major drivers of tumorigenesis. NF-κB p65 overactivation and cGAS silencing important triggers genetic defects that accelerate However, the simultaneous correction remains to be further explored. Here, we propose a novel I nduced D ual- T arget R ebalance (IDTR) strategy for simultaneously correcting in p65. By using our IDTR approach, showed first time oncolytic adenovirus H101 could reactivate silenced cGAS, while GAU1 long noncoding RNA (lncRNA)...
The three-stranded DNA-RNA triplex hybridization is involved in various biological processes, including gene expression regulation, DNA repair, and chromosomal stability. However, the mediating mechanisms underlying tumorigenesis remain to be fully elucidated. Here, we show that peptidylprolyl isomerase A (PPIA) serves as anchor recruit GAU1 lncRNA by interacting with exon 4 of enhances formation SENP5/GAU1 DNA-lncRNA triplex. Intriguingly, TFR4 region 3 TTS4 SENP5 promoter constitute...