A5101520405- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- Synthesis and properties of polymers
- Circular RNAs in diseases
- Genomic variations and chromosomal abnormalities
- Protein Degradation and Inhibitors
- Estrogen and related hormone effects
- Signaling Pathways in Disease
- Tribology and Wear Analysis
- Pancreatic and Hepatic Oncology Research
- Analytical Chemistry and Chromatography
- Barrier Structure and Function Studies
- Chemical Synthesis and Analysis
- Steroid Chemistry and Biochemistry
- Electronic Packaging and Soldering Technologies
- Inflammatory mediators and NSAID effects
- Immunotherapy and Immune Responses
- Genomics and Phylogenetic Studies
- Cancer-related gene regulation
- Genomics and Rare Diseases
- Cancer Genomics and Diagnostics
- Nanoplatforms for cancer theranostics
Shanghai East Hospital
2023-2024
Jinggangshan University
2023-2024
Wuxi Fourth People's Hospital
2021-2024
Sun Yat-sen University
2021-2023
Fifth Affiliated Hospital of Sun Yat-sen University
2021-2023
Jiangnan University
2022
Chengdu Medical College
2021
First Affiliated Hospital of Chengdu Medical College
2021
Peking University People's Hospital
2019
Peking University
2019
Abstract Background Colorectal cancer (CRC) is a major cause of cancer-related deaths worldwide, and chemoresistance obstacle in its treatment. Despite advances therapy, the molecular mechanism underlying CRC not fully understood. Recent studies have implicated key roles long noncoding RNAs (lncRNAs) regulation chemoresistance. Methods In this study, we investigated role lncRNA LINC01852 expression was evaluated multiple cohorts using quantitative reverse transcription PCR. We conducted...
Small nucleolar RNA host gene (SNHG) long noncoding RNAs (lncRNAs) are frequently dysregulated in human cancers and involved tumorigenesis progression. SNHG17 has been reported as a candidate oncogene several cancer types, however, its regulatory role colorectal (CRC) is unclear.SNHG17 expression multiple CRC cohorts was assessed by RT-qPCR or bioinformatic analyses. Cell viability evaluated using Counting Kit-8 (CCK-8) colony formation assays. mobility invasiveness were Transwell Tumor...
Abstract Background SLCO4A1-AS1 was found to be upregulated in several cancer types, including colorectal (CRC). However, the detailed roles of CRC remain elucidated. Therefore, we investigated functions, mechanism, and clinical significance tumourigenesis. Methods We measured expression tissues using qRT-PCR determined its correlation with patient prognosis. Promoter methylation analyses were used assess status SLCO4A1-AS1. Gain- loss-of-function assays evaluate effects on growth vitro...
Benzotriazole and its derivatives show good tribological properties, anti-oxidation, anti-corrosion, rust prevention dispersion capabilities as lubricating additives, becoming the common multifunctional additives. And how to avoid sulfur- or phosphorus-introduction improve their functionality compatibility with hydrocarbons is forefront research. In this study, methylbenzotriazole oleic acid were applied synthesize a new methylbenzotriazole-amide that long alkyl-chain...
Bladder cancer (BLCA) is a common genitourinary in patients, and tumour angiogenesis indispensable for its occurrence development. However, the indepth mechanism of BLCA remains elusive. According to recent studies, tight junction protein family member occludin (OCLN) expressed at high levels tissues correlates with poor prognosis. Downregulation OCLN inhibits cells murine xenografts, whereas overexpression exerts opposite effect. Mechanistically, RT-qPCR analysis Western blotting results...
Triple-negative breast cancer is a highly aggressive and metastatic tumor; diagnosing it in the early stages still difficult, prognosis for conventional radio-chemotherapy immunotreatment not promising due to cancer's immunosuppressive microenvironment. The utilization of protein-based nanosystem has proven be effective delivering agents with limited adverse effects, yet combination diagnosis treatment remains difficult challenge. This research took advantage natural albumin organic...
CircRNAs play diverse roles in the regulation of oncogenic processes, yet these circRNAs non–small cell lung cancer (NSCLC) remain to be fully clarified. Herein, patterns circRNA expression NSCLC tissues and paracancerous were assessed, relationships between patient clinical findings assessed. evaluated using a microarray approach, with Quantitative real‑time polymerase chain reaction (qPCR) qPCR being used validate candidate levels patients peripheral blood samples. GEO2R was analyze array...
Pancreatic ductal adenocarcinoma (PDAC), a fatal malignant tumour, has high postoperative recurrence rate, mainly due to the difficulty of discerning occult lesions, including those related perineural invasion (PNI) and lymph node metastasis (LNM). Cellular mesenchymal-epithelial transition factor (c-Met), an excellent imaging marker, is aberrantly expressed in majority PDACs. Thus, we plan utilize c-Met-targeted near-infrared fluorescent (NIRF) probe for real-time visualization dissection...
The three-stranded DNA-RNA triplex hybridization is involved in various biological processes, including gene expression regulation, DNA repair, and chromosomal stability. However, the mediating mechanisms underlying tumorigenesis remain to be fully elucidated. Here, we show that peptidylprolyl isomerase A (PPIA) serves as anchor recruit GAU1 lncRNA by interacting with exon 4 of enhances formation SENP5/GAU1 DNA-lncRNA triplex. Intriguingly, TFR4 region 3 TTS4 SENP5 promoter constitute...
<div>Abstract<p>In this report, we show that expression of a <i>NUP98–PHF23</i> (<i>NP23</i>) fusion, associated with acute myeloid leukemia (AML) in humans, leads to myeloid, erythroid, T-cell, and B-cell mice. The leukemic preleukemic tissues display stem cell–like signature, including <i>Hoxa</i>, <i>Hoxb</i>, <i>Meis1</i> genes. PHF23 plant homeodomain (PHD) motif is known bind H3K4me3 residues, chromatin...
<div>Abstract<p>The PAX3-FKHR fusion protein is present in a majority of alveolar rhabdomyosarcomas associated with increased aggressiveness and poor prognosis. To better understand the molecular pathogenesis PAX3-FKHR, we carried out first, unbiased genome-wide identification binding sites target genes rhabdomyosarcoma. The data shows that binds to same as PAX3 at both <i>MYF5</i> <i>MYOD</i> enhancers. analysis reveals are (<i>a</i>) mostly...
Circulating tumor DNA (ctDNA) in plasma of cancer patients provides valuable information about the and also holds great promise for non-invasive early detection. Nevertheless, since ctDNA is diluted by circulating cell-free (cfDNA) noncancerous origins, its detection poses significant challenge, especially during stage cancer. Previous studies on have mostly focused single feature ctDNA, namely either driver gene mutations or alterations methylome. We developed a set experimental...