A5039083519- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Acute Myeloid Leukemia Research
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Cancer-related gene regulation
- RNA modifications and cancer
- CRISPR and Genetic Engineering
Institut Cochin
2022-2024
Université Paris Cité
2022-2023
Centre National de la Recherche Scientifique
2022-2023
Epigénétique et Destin Cellulaire
2023
Inserm
2022
Fondation pour la Recherche Médicale
2022
Abstract Myelodysplastic syndromes (MDS) with mutated SF3B1 gene present features including a favourable outcome distinct from MDS mutations in other splicing factor genes SRSF2 or U2AF1 . Molecular bases of these divergences are poorly understood. Here we find that -mutated show reduced R-loop formation predominating bodies associated intron retention reduction, not found - MDS. Compared to erythroblasts SRSF2- patients, exhibit augmented DNA synthesis, accelerated replication forks, and...
Abstract Epigenetic mechanisms are essential to establish and safeguard cellular identities in mammals. They dynamically regulate the expression of genes, transposable elements higher-order chromatin structures. Consequently, these marks indispensable for mammalian development alterations often lead disease, such as cancer. Bivalent promoters especially important during differentiation development. Here we used a genetic screen identify new regulators bivalent repressed gene. We BEND3...