Rheumatology has pioneered in the study of autoantibodies by showing that they are not only involved pathogenesis but also highly useful as diagnostic biomarkers.The biomarker aspect autoimmunity gained increasing importance cancer and many insights have contributed to understanding significance cancer.Features rheumatic disorders: In diseases no individual autoantibody-antigen system sufficient combination sensitivity specificity serve a biomarker.Instead, several antigen-antibody systems...

Background SLE is distinguished by the development of multiple autoantibodies that lead to chronic inflammation and increased risk cardiovascular diseases, especially atherosclerosis. Objective This examination sought explore association between disease activity, clinical manifestations, medication with atherosclerotic lesion from patients. Methods inquiry investigated forty-two female patients (18-45 years old) who met 2019 EULAR/ACR assortment decency matched healthy individuals as control...

The balance between T helper 17 (Th17) and regulatory cells (Treg) is a new paradigm in the pathogenesis of systemic lupus erythematosus (SLE). Currently, there are no drugs that able to modulate Th17/Treg specifically SLE. Curcumin bioactive agent has specific action against hyperproliferative cells. However, its role modulating SLE still unknown. This research aimed investigate curcumin on CD4+ cell cultures patients.CD4+ from 6 untreated patients healthy subjects were collected,...

This study was aimed to determine the diagnostic performance of transforming growth factor beta 1 (uTGF-β1), monocyte chemoattractant protein-1 (uMCP-1), neutrophil gelatinase-associated lipocalin (uNGAL) and interleukin 17 (uIL-17) in LN. Seventy participants were studied, categorized into three groups: 38 severe LN (class III-IV patients); 12 mild I-II 20 control (healthy volunteers). Diagnosis SLE based on 1997 ARA criteria. Class NL classified according ISN/RPS 2004. uTGF-β1, uMCP-1,...

Background: Mangosteen (Garcinia mangostana Linn.) is tropical fruit that known to contain bioactive compounds which has particular function as antioxidants, anti-inflammatory and antibacterial. rind extract have high contents of xanthone antioxidant free radical scavenging activities. This study was aiming determine the derivatives using Liquid Chromatography Mass Spectrometry (LC-MS/MS) activity six different maturity levels mangosteen electron spin resonance (ESR). Method: classified...

Abstract Epilepsy affects around 50 million people worldwide, with 30% of them being refractory epilepsy. This shows that there is still a need for novel anti-seizure medication have different mechanisms. One the most common types epilepsy temporal lobe Among several effects seizures on neurons an increase in intracellular Ca2+ and activation RhoA. Rapamycin mTORC1 inhibitor, but long-term exposure to rapamycin (>18 hours) could also inhibit mTORC2. RhoA signaling pathway regulated...

Background. Curcumin contained in Curcuma xanthorrhiza is an immunomodulator that has similar biological effect as vitamin D. Combination of curcumin and D 3 expected to work synergistically. Objective. To determine the supplementation on administration SLEDAI, IL-6, TGF- β 1 serum SLE patients with hypovitamin Methods. This was a double-blind RCT conducted Saiful Anwar Hospital, Malang, January 2016–March 2017. Subjects were active (SLEDAI > 3) levels 25(OH)D3 ≤ 30 ng/ml divided into two...

Abstract Aim To assess the factors defining healthcare‐seeking behavior of people with musculoskeletal pain in urban community Malang City, East Java, Indonesia. Methods A cross‐sectional survey was performed In total, 2067 participants aged 16‐93 years were interviewed. The sociodemographic and socioeconomic healthcare seeking behavior, pain, disability, adverse drug reactions assessed using validated Indonesian version Community Oriented Program for Control Rheumatic Disease (COPCORD)...

Abstract Aims Cognitive impairment is common in systemic lupus erythematosus (SLE) patients with substantial adverse effects on function and quality of life. One hypothesis to understand the mechanisms cognitive SLE accelerated immunosenescence. The aim this study observe correlation between immunosenescence SLE. Methods Sixty‐one female patient were measured for CD4 CD8 T cell‐associated senescence markers, including percentage end‐stage differentiated cells (CD4 expressing CD57 + or loss...

The involvement of mucin, lectin, and apoptosis in colitis is still unclear. This study aimed to investigate changes MUC2 expression, inflammation, lectin expression patients.

The sequestration of infected erythrocytes in the placenta can activate syncytiotrophoblast to release cytokines that affect micro-environment and influence delivery nutrients oxygen fetus. high level IL-10 has been reported intervillous space could prevent pathological effects. There is still no data Th17 involvement pathogenesis placental malaria. This study was conducted reveal IL-17 levels on fetal weights malaria placenta. Seventeen pregnant BALB/C mice were divided into control (8...

This study aimed to observe the association between presence of hypertension with Covid-19 vaccine effectiveness among healthcare workers who received CoronaVac vaccination.We conducted a prospective cohort in Saiful Anwar General Hospital, Malang, Indonesia on 155 aged 18-59 years old already twice (Sinovac Life Science, Beijing, China) injection 14-day intervals. Hypertension was diagnosed according 2020 International Society Hypertension. Subjects were monitored for six months. The...

Systemic lupus erythematosus (SLE) patients are predisposed to chronic immune activation, leading accelerated immunosenescence. The aging of the system causes T cells express several senescence markers such as CD57 and KLRG1, which produce pro-inflammatory cytokine interferon γ (IFN-γ). Immunosenescence was associated with high morbidity mortality in other diseases. This research conducted prove association between senescent SLE disease activity.This an observational cross-sectional study on...

This study was aimed to explore the association of vitamin D in risk coagulopathy coronavirus disease-19 (COVID-19).Clinical and laboratory findings were obtained from 50 confirmed COVID-19 patients hospitalized Saiful Anwar General Hospital, Malang, Indonesia, September November 2020. Thrombotic events during hospitalization recorded, ISTH disseminated intravascular coagulation (DIC) score used classify overt DIC. Hypovitaminosis defined by serum level <49.92 nmol/L.Among patients, 42 (84%)...

Lupus Nephritis (LN) is a serious manifestation of lupus that can lead to End Stage Renal Disease (ESRD). Fibrosis the main feature ESRD, and it likely influenced by Transforming Growth Factor Beta1 (TGFβ1). The T869C gene polymorphism TGFβ1 assumed change signal peptide, has potential interfere urine production renal protein expression TGFβ1. influence on fibrosis was evaluated in this study. Subjects were 45 patients LN with participants without as control, recruited from 2011 2013.Their...

Abstract Wharton’s Jelly is one of the best sources for mesenchymal stem cells. Human Mesenchymal Stem Cells (hWJ-MSCs) have high proliferation, multi-lineage differentiation potential, and do not produce any teratogen or carcinogen. These characteristics make hWJ-MSCs become suitable regenerative medicine. Some methods were developed to isolate from umbilical cord, such as explant method enzymatic method. This study aims characterize which are isolated by two different methods, attachment...

Objective:The objective of this study was to determine whether Ramadan fasting (RF) alters the ability serum, peripheral blood mononuclear cells (PBMC) and macrophages kill Mycobacterium tuberculosis (M.tb).Methods: Thirty healthy male volunteers who fasted during participated in study.Blood sampling conducted seven days before on seventh 21 st day Ramadan.The following parameters were measured by ELISA: Complement C3, inducible nitric oxide synthase (iNOS), superoxide dismutase (SOD) levels...

To explore the potential activity of Orthosiphon aristatus (OA) against atopic dermatitis (AD). Phytocompounds from OA were identified through chromatography analysis, then continued to target identification and functional annotation OA. Then, network pharmacology annotated proteins determined protein targets for phytocompounds. Protein with highest rank according betweenness closeness algorithm molecular docking validated dynamics analysis. Chromatography data analysis revealed thirty-six...

Despite the development of anti-epilepsy drugs, drug-refractory epilepsy still becomes a challenging problem along with an increased incidence epilepsy. To face that challenge and increase patients’ quality life, treatment must effectively prevent epileptogenesis, not only symptomatic treatment. AKT signaling pathway was proven to have important roles in through its function synaptic plasticity, neurogenesis, axon guidance, modulation glutamate transporter, activation Ca2+ channel. also...

Introduction: This research discusses the potential of Orthosiphon aristatus, a medicinal plant, in improving skin lesions Atopic Dermatitis by regulating Th2 cytokines and showing anti-allergic activity. Methods: The study was conducted using BALB/C mice induced with DNCB for 21 days to create an atopic dermatitis model. Then, were orally administered aristatus extract 14 (after 7 induction). doses given divided into six groups: 17.5 mg/kgbw, 35 70 140 mg/kgbw. Molecular levels such as IgE,...