A5039965039- Metastasis and carcinoma case studies
- Lung Cancer Research Studies
- Nanoplatforms for cancer theranostics
- Congenital Diaphragmatic Hernia Studies
- Sirtuins and Resveratrol in Medicine
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Cancer Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Cancer Research and Treatments
- Plant Molecular Biology Research
- Virus-based gene therapy research
- Autophagy in Disease and Therapy
- Cancer Mechanisms and Therapy
- Gastric Cancer Management and Outcomes
- FOXO transcription factor regulation
Sun Yat-sen University Cancer Center
2001-2024
Sun Yat-sen University
2001-2024
Substantial evidence suggests that breast cancer initiation, recurrence and drug resistance is supported by stem cells (BCSCs). Recently, we reported a novel role of Aurora kinase A (AURKA) in BCSCs, as transactivating co-factor the induction c-Myc oncoprotein. However, mode action transcriptional network nuclear AURKA BCSCs remain unknown. Here, report can be recruited Forkhead box subclass M1 (FOXM1) to transactivate FOXM1 target genes kinase-independent manner. In addition, show...
Clear cell renal carcinoma (ccRCC) is a malignancy with dismal prognosis, caused by the buildup of fat and glycogen. Sirtuin 1 (Sirt1) deacetylase that regulates lipid metabolism. In this study, we collected tumor paracancer tissues from 386 ccRCC patients followed their prognosis over an extended time period. The expression Sirt1 in these was assessed using immunohistochemistry, LinkedOmics database analysis identified differentially expressed genes associated Sirt1. survival curve...
Abstract Development of cancer gene therapy has been hampered by the fact that there are no effective cancer-specific expression vectors available, which is critical for improving therapeutic efficacy and reducing toxicity in clinics. To overcome this problem, we recently developed a safe strategy fro targeting potent pro-apoptotic (BikDD) to pancreatic tumors (Xie et al. Cancer Cell, 2007), lung (Sher Oncogene, 2009) ovarian Molecular Therapeutics, 2009). A VISA system (VP16-Gal4-WPRE...
To minimize the morbidity of thoracotomy for thoracic tumors.From Oct. 2000 to Sept. 2001, 40 patients ( male 26, female 14, with age 20-79 years old) underwent thoracotomies, in which 15 had lung cancer, 1 carcinoid, infectious cyst lung, 2 pulmonary inflammatory pseudotumor, thymoma, and 19 esophageal carcinoma. Inframammary incision, muscle-sparing serratuas-sparing posterolateral thracotomy were done conduct lobectomy or bilobectomy 17, segmentectomy 1, middle plus sleeve resection...