A5038737340- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Cardiac tumors and thrombi
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Cardiovascular Effects of Exercise
- Infective Endocarditis Diagnosis and Management
- Viral Infections and Immunology Research
- Coronary Artery Anomalies
- Coronary Interventions and Diagnostics
- Drug-Induced Hepatotoxicity and Protection
- Congenital Diaphragmatic Hernia Studies
- Infectious Disease Case Reports and Treatments
- Lipoproteins and Cardiovascular Health
- Connective tissue disorders research
- Moyamoya disease diagnosis and treatment
- Innovation Policy and R&D
- PARP inhibition in cancer therapy
- Acute Kidney Injury Research
Eastern Health
2021-2024
The Royal Melbourne Hospital
2018-2024
The University of Melbourne
2024
Affiliated Hospital of Hebei University
2024
Hebei Medical University
2024
Guangdong Pharmaceutical University
2022
First Affiliated Hospital of Guangdong Pharmaceutical University
2021
Melbourne Health
2016
Abstract Purpose Methyltransferase-like 3 (METTL3), a key member of the m6A methyltransferase complex, is upregulated in multiple human malignancies and plays role regulating tumor migration. This study aimed to reveal underlying mechanism by which METTL3 regulates metastasis colorectal cancer (CRC). Methods We compared expression levels CRC tissues adjacent nontumor immunohistochemistry (IHC). The functional roles were assessed real-time cell migration assays, wound-healing assays Transwell...
Pancreatic cancer is a kind of malignant tumor with high mortality rate. Early operation and late chemoradiotherapy are the treatment criteria, but prognosis still poor. Berberine, an alkaloid compound present in many herbal plants, capable inducing oxidative DNA damage downregulating homologous recombination repair (HRR) cells. Poly (ADP ribose) polymerase-1 (PARP-1) sensor key roles repair. In this study, we demonstrated that berberine PARP inhibitor olaparib have synthetic lethal effect...
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Previous large multi-centre randomised controlled trials have not provided clear benefit with routine intracoronary thrombus aspiration (TA) as an adjunct to primary percutaneous coronary intervention (PCI) in patients ST-elevation myocardial infarction (STEMI).To determine whether there is a difference outcomes the use of manual TA prior PCI, compared PCI alone cohort STEMI.We analysed data from 6270 consecutive undergoing for STEMI prospectively enrolled Melbourne Interventional Group...
Acute kidney injury (AKI) is a common complication of cardiac surgery, and associated with increased morbidity mortality. It may have multiple causes including intraoperative renal ischaemia reperfusion due to cardiopulmonary bypass, low postoperative output, nephrotoxic drugs. Bradycardia as cause AKI has rarely been reported.