A5020666593- Microbial Natural Products and Biosynthesis
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Computational Drug Discovery Methods
- Mycobacterium research and diagnosis
- Biochemical and Molecular Research
- Antibiotic Resistance in Bacteria
University of Zagreb
2024
Taras Shevchenko National University of Kyiv
2022-2024
University of Ljubljana
2023
ABSTRACT Most biosynthetic gene clusters (BGC) encoding the synthesis of important microbial secondary metabolites, such as antibiotics, are either silent or poorly expressed; therefore, to ensure a strong pipeline novel there is need develop rapid and efficient strain development approaches. This study uses comparative genome analysis instruct rational improvement, using Streptomyces rimosus , producer antibiotic oxytetracycline (OTC) model system. Sequencing genomes two industrial strains...
Abstract Most of the biosynthetic gene clusters (BGC) encoding biosynthesis important microbial secondary metabolites, such as antibiotics, are either silent or poorly expressed; therefore, robust technologies required to secure production natural products for both drug discovery and any subsequent commercial fermentation processes. Industrial strain improvement has resulted almost exclusively from expensive time-consuming approaches improvement. Therefore, ensure a strong pipeline truly...
Aim.To identify the potential novel membrane drug targets of Acinetobacter baumannii ATCC 19606.Methods.Clustering paralogues was performed by USEARCH software, identification essential non-homologous proteins to human proteome done with BLASTp and Database genes, determination from unique metabolic pathways carried out using KAAS server at KEGG.The target novelty estimated DrugBank.The sub-cellular localization predicted PSORTb v. 3.0.3,CELLO 2.5 BUSCA.Tertiary structures were built...