A5101625726- Pancreatic function and diabetes
- Birth, Development, and Health
- Diabetes and associated disorders
- Gestational Diabetes Research and Management
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Thyroid Cancer Diagnosis and Treatment
- Sinusitis and nasal conditions
- Pluripotent Stem Cells Research
- Diabetes Management and Research
- Liver Diseases and Immunity
- Hippo pathway signaling and YAP/TAZ
- Pregnancy and preeclampsia studies
- Liver Disease and Transplantation
- Immune cells in cancer
- Cancer Cells and Metastasis
- Head and Neck Surgical Oncology
- Cancer Research and Treatments
- Genetics and Neurodevelopmental Disorders
- Stress Responses and Cortisol
- Axon Guidance and Neuronal Signaling
- Phagocytosis and Immune Regulation
- Thyroid Disorders and Treatments
- Cannabis and Cannabinoid Research
Central South University
2011-2025
Third Xiangya Hospital
2011-2025
Education Department of Heilongjiang Province
2024
Chinese Center For Disease Control and Prevention
2024
Harbin Medical University
2024
University of Electronic Science and Technology of China
2024
Huazhong University of Science and Technology
2020-2024
Beijing Chao-Yang Hospital
2012-2023
Capital Medical University
2012-2023
Pennington Biomedical Research Center
2019-2021
We have reproduced a previously described method for the in vitro generation of endocrine cells adult human pancreatic tissue culture. The aim this study was to characterize nature progenitor and identify factors necessary their differentiation model. During monolayer expansion, two types proliferated sequentially; first cytokeratin 19 (CK19)-positive ductal epithelial then nestin-positive fibroblastoid cells. After bromodeoxyuridine-labeled were traced differentiated islet buds, some...
Epidermal growth factor receptor (EGF-R) signaling is essential for proper fetal development and of pancreatic islets, there also evidence its involvement in beta-cell signal transduction the adult. To study functional roles EGF-R physiology postnatal life, we have generated transgenic mice that carry a mutated under duodenal homeobox-1 promoter (E1-DN mice). The transgene was expressed islet beta- delta-cells but not alpha-cells, as expected, it resulted an approximately 40% reduction...
Although genome-wide association studies have identified the gene RNF186 encoding an E3 ubiquitin-protein ligase as conferring susceptibility to ulcerative colitis, exact function of this protein remains unclear. In present study, we demonstrate important role for in macroautophagy/autophagy activation colonic epithelial cells and intestinal homeostasis. Mechanistically, acts EPHB2 regulates ubiquitination EPHB2. Upon stimulation by ligand EFNB1 (ephrin B1), is ubiquitinated at Lys892,...
Background: We investigated the association between prenatal GDM exposure and offspring DNA methylation (DNAm) age at 3–10 years of in Tianjin Observational Study.Methods: This study included 578 non-GDM mother-child pairs. Children underwent an exam with anthropometric measurements blood draw for DNAm analysis (Illumina 850 K array) a median 5.9 (range 3.1–10.2). was calculated using two epigenetic clock algorithms (Horvath Hannum). The residual resulting from regressing on chronological...
Significance Each year, the global mortality rates for fungal diseases now exceed those malaria and breast cancer are currently comparable to tuberculosis HIV. The limited scope of available antifungal drugs is major factor underlying observed high rate. Here, we provide evidence that Myosin IF (MYO1F) plays a critical role in mediating signaling molecules “trafficking from membrane cytoplasm,” this process essential pathway activation. Moreover, Sirt2 deacetylase inhibitors promote immunity...
Abstract Background To investigate the relationship between health-related quality of life (HRQOL) and survival in Chinese patients with chronic liver disease (CLD). Methods HRQOL was measured version Short Form 36 (SF-36). SF-36 scores, demographic clinical data were collected at baseline after 18 months follow-up. Kaplan-Meier Cox Proportional Hazard Regression analyses used for interpretation data. Surviving censored analyses. Results A total 415 CLD 86 healthy controls enrolled. During...
Abstract IL-17A plays an essential role in the pathogenesis of many autoimmune diseases, including psoriasis and multiple sclerosis. Act1 is a critical adaptor signaling pathway. In this study, we report that anti-sense long noncoding RNA, TRAF3IP2-AS1, regulates expression by recruiting SRSF10, which downregulates IRF1, transcriptional factor Act1. Interestingly, found psoriasis-susceptible variant TRAF3IP2-AS1 A4165G (rs13210247) gain-of-function mutant. Furthermore, identified mouse gene...
The immune system plays a crucial role in initiating, progressing, and disseminating HNSCC. This study aims to investigate the differences microenvironments between 2D-4-culture 3D-4-culture models of head neck squamous cell carcinoma (HNSCC) cells (FaDu), human fibroblasts (HF), monocytes (THP-1), endothelial (HUVEC). For model, FaDu:HF:THP-1 (2:1:1) were inoculated an ultra-low attachment culture plate, while HUVECs placed transwell chamber. ordinary plate was used for model....
Aim . To investigate the factors contributing to health-related quality of life (HRQOL) in Chinese patients with chronic liver disease (CLD). Methods HRQOL was measured SF-36v2 version. Demographic and clinical data were collected, cirrhosis divided into Child’s Class A, B, C according Child-Turcotte-Pugh scoring system. Results A total 392 CLD 91 healthy controls enrolled. lower than that controls. Score PCS was<mml:math...
The aim of this study was to elucidate the relationships between thyroid hormones, lifestyle factors, biochemical markers, and autoimmune disease (AITD), thereby identifying factors influencing development these diseases.
Assuming that neogenesis contributes to long-term function of islet grafts, it is important study the effects immunosuppressive drugs on precursor cell proliferation and differentiation. We examined low-dose these processes in vitro. Immunosuppressive drugs, including sirolimus, tacrolimus, mycophenolate mofetil (MMF), daclizumab their combinations were tested parallel culture wells through either expansion phase (5-7 days) or entire period (4-5 weeks). MMF, alone combination with sirolimus...
Abstract Background: Nasopharyngeal carcinoma (NPC) is a disease highly sensitive to radiotherapy with the unclear etiology. However, specific effects of microRNA-613 (miR-613) on NPC still remain elusive. Therefore, present study probes into underlying mechanism miR-613 in via AKT signaling pathway by regulating Fibronectin 1 (FN1). Methods: First, microarray analysis was used screen differentially expressed genes (DEGs) and regulatory miRs associated NPC. Next, FN1 expression cells...
Neonatal Sprague-Dawley rats were randomly divided into normal control, mild hypoxia-ischemia (HI), and severe HI groups (N = 10 in each group at time) on postnatal day 7 (P7) to study the effect of anxiety-like behavior expression tyrosine hydroxylase (TH) substantia nigra (SN). The exposed hypoxia (8% O2/92% N2) for 90 150 min, respectively. elevated plus-maze (EPM) test was performed assess by measuring time spent open arms (OAT) OAT%, immunohistochemistry used determine TH SN P14, P21,...
Objective This study aims to analyze the relationship between papillary thyroid carcinoma (PTC) and various factors. Methods The involved two groups—PTC patients non-PTC controls. We utilized binary logistic regression Least Absolute Shrinkage Selection Operator (Lasso) for variable selection risk factor analysis. Correlation analysis was performed using Spearman’s rank correlation. diagnostic value of stimulating hormone (TSH) levels PTC assessed Receiver Operating Characteristic (ROC)...
Background & objectives: Examine maternal gestational diabetes mellitus (GDM), macrosomia and DNA methylation in candidate genes IGF1, IGF2, H19, ARHGRF11, MEST, NR3C1, ADIPOQ RETN. Materials methods: A total of 1145 children (572 GDM cases 573 controls) from the Tianjin study, including 177 with macrosomia, had blood collection at median age 5.9 (range: 3.1-10.0). We used logistic regression to screen for associations model on 37 CpGs, performed mediation analysis. Results: One CpG was...
The receptor tyrosine kinase EPHB2 (EPH B2) is highly expressed in many human cancer types, especially gastrointestinal cancers, such as colorectal cancer. Several coding mutations of the gene have been identified suggesting that plays a critical role carcinogenesis. However, exact functional mechanism carcinogenesis remains unknown. In this study, we find required for TNF-induced signaling activation and proinflammatory cytokine production epithelial cells. Mechanistically, after TNF...