A5083129448- Nerve injury and regeneration
- Pain Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Animal testing and alternatives
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Neurogenetic and Muscular Disorders Research
- Ion channel regulation and function
- Animal Genetics and Reproduction
University of Lausanne
2023
University Hospital of Lausanne
2023
Lund University
2018
Satellite glial cells (SGCs), enveloping primary sensory neurons' somas in the dorsal root ganglion (DRG), contribute to neuropathic pain upon nerve injury. Glial fibrillary acidic protein (GFAP) serves as an SGC activation marker, though its DRG satellite cell specificity is debated. We employed hGFAP-CFP transgenic mouse line, designed for astrocyte studies, explore expression within peripheral nervous system (PNS) after spared injury (SNI). used diverse immunostaining techniques, Western...
Abstract Macrophages and satellite glial cells are found between injured uninjured neurons in the lumbar dorsal root ganglia (DRG). We explored mechanism of neuro‐immune neuron–glia crosstalk leading to hyperexcitability DRG neurons. After spared nerve injury (SNI), CX3CR1 + resident macrophages became activated, proliferated, increased inward‐rectifying potassium channel K ir 2.1 currents. Conditioned medium (CM) by macrophages, obtained from SNI mice, sensitized small naïve mice. However,...
Abstract Macrophages and satellite glial cells are found between injured uninjured neurons in the lumbar dorsal root ganglia (DRG). We explored mechanism of neuro-immune neuron–glia crosstalk leading to hyperexcitability DRG neurons. After spared nerve injury (SNI), CX3CR1 + resident macrophages became activated, proliferated increased inward-rectifying potassium channel K ir 2.1 currents. Conditioned medium (CM) by macrophages, obtained from SNI mice, sensitised small naïve mice. However,...