A5039163515- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Nerve injury and regeneration
- Sleep and Wakefulness Research
- Pharmacological Receptor Mechanisms and Effects
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Neurotransmitter Receptor Influence on Behavior
- Botulinum Toxin and Related Neurological Disorders
- Ion channel regulation and function
- Veterinary Practice and Education Studies
- Nicotinic Acetylcholine Receptors Study
- Osteoarthritis Treatment and Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Laser Applications in Dentistry and Medicine
- Cancer Treatment and Pharmacology
- Transcranial Magnetic Stimulation Studies
- Circadian rhythm and melatonin
- Neuroscience of respiration and sleep
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Primate Behavior and Ecology
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
University of Lausanne
2017-2023
University Hospital of Lausanne
2023
Centre National de la Recherche Scientifique
2010-2016
Institut des Neurosciences Cellulaires et Intégratives
2016
Université de Strasbourg
2010-2014
Institut de génétique et de biologie moléculaire et cellulaire
2014
Inserm
2013-2014
Institut de Biologie Moléculaire et Cellulaire
2013
Frequent nightly arousals typical for sleep disorders cause daytime fatigue and present health risks. As such are often short, partial, or occur locally within the brain, reliable characterization in rodent models of human patients is challenging. We found that EEG spectral composition non-rapid eye movement (NREMS) healthy mice shows an infraslow (~50 s) interval over which microarousals appear preferentially. NREMS could hence be vulnerable to abnormal on this time scale. Chronic pain...
Satellite glial cells (SGCs), enveloping primary sensory neurons' somas in the dorsal root ganglion (DRG), contribute to neuropathic pain upon nerve injury. Glial fibrillary acidic protein (GFAP) serves as an SGC activation marker, though its DRG satellite cell specificity is debated. We employed hGFAP-CFP transgenic mouse line, designed for astrocyte studies, explore expression within peripheral nervous system (PNS) after spared injury (SNI). used diverse immunostaining techniques, Western...
The antidiabetic drug metformin has been shown to reduce pain hypersensitivity in preclinical models of chronic and neuropathic humans. Multiple intracellular pathways have described as targets. Among them, is an activator the adenosine 5′-monophosphate protein kinase that can turn modulate activity E3 ubiquitin ligase NEDD4-2 thus post-translational expression voltage-gated sodium channels (Na<sub>V</sub>s). In this study, we found bulk effect on Na1.7 dependent NEDD4-2. HEK cells,...
Abstract Macrophages and satellite glial cells are found between injured uninjured neurons in the lumbar dorsal root ganglia (DRG). We explored mechanism of neuro‐immune neuron–glia crosstalk leading to hyperexcitability DRG neurons. After spared nerve injury (SNI), CX3CR1 + resident macrophages became activated, proliferated, increased inward‐rectifying potassium channel K ir 2.1 currents. Conditioned medium (CM) by macrophages, obtained from SNI mice, sensitized small naïve mice. However,...
Chronic heavy alcohol use is known to cause neurological complications such as peripheral neuropathy. Concerning the pathophysiology, few sural nerve and skin biopsy studies showed that small fibers might be selectively vulnerable degeneration in alcohol-related Pain has rarely been properly evaluated this pathology. The present study aims at assessing pain intensity, potential neuropathic characteristics well functionality of both large sensitive fibers.In observational study, 27...
Abstract Chronic pain patients frequently suffer from sleep disturbances. Improvement of quality alleviates pain, but neurophysiological mechanisms underlying disturbances require clarification to advance therapeutic strategies. causes high-frequency electrical activity in pain-processing cortical areas that could disrupt the normal process low-frequency rhythm generation. We found spared-nerve-injury (SNI) mouse model, mimicking human neuropathic had preserved sleep-wake behavior. However,...
Abstract Macrophages and satellite glial cells are found between injured uninjured neurons in the lumbar dorsal root ganglia (DRG). We explored mechanism of neuro-immune neuron–glia crosstalk leading to hyperexcitability DRG neurons. After spared nerve injury (SNI), CX3CR1 + resident macrophages became activated, proliferated increased inward-rectifying potassium channel K ir 2.1 currents. Conditioned medium (CM) by macrophages, obtained from SNI mice, sensitised small naïve mice. However,...