Matías Pizarro

ORCID: 0009-0005-7397-1515
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About
Contact & Profiles
Research Areas
  • Extracellular vesicles in disease
  • RNA Interference and Gene Delivery
  • interferon and immune responses
  • MicroRNA in disease regulation
  • Speech Recognition and Synthesis
  • Speech and Audio Processing
  • Engineering Education and Curriculum Development
  • Natural Language Processing Techniques
  • Marine and coastal plant biology
  • Tryptophan and brain disorders
  • Autophagy in Disease and Therapy
  • Higher Education and Sustainability
  • Anomaly Detection Techniques and Applications
  • Hate Speech and Cyberbullying Detection
  • Gut microbiota and health
  • Diverse Musicological Studies
  • Stress Responses and Cortisol
  • Advanced Nanomaterials in Catalysis
  • Coastal wetland ecosystem dynamics
  • Marine Biology and Ecology Research
  • Music Technology and Sound Studies
  • Peptidase Inhibition and Analysis

Universidad de Los Andes
2023-2024

Universidad de Los Andes, Chile
2013-2023

Ruhr University Bochum
2021

Universidad Católica del Norte
2009

In the last few decades, it has been established that astrocytes play key roles in regulation of neuronal morphology. However, contribution astrocyte-derived small extracellular vesicles (sEVs) to morphological differentiation neurons only recently addressed. Here, we showed cultured expressing a GFP-tagged version stress-regulated astrocytic enzyme Aldolase C (Aldo C-GFP) release are transferred into hippocampal neurons. Surprisingly, Aldo C-GFP-containing sEVs C-GFP sEVs) displayed an...

10.3390/cells9040930 article EN cc-by Cells 2020-04-10

In the last decades, it has been established that astrocytes play key roles in regulation of neuronal morphology. However, contribution astrocyte-derived small extracellular vesicles (sEVs) to morphological differentiation neurons only recently addressed. Here, we showed cultured expressing a GFP tagged version stress-regulated astrocytic enzyme Aldolase C (Aldo C-GFP) release which are transferred into hippocampal neurons. Surprisingly, Aldo C-GFP-containing sEVs C-GFP sEVs) displayed an...

10.20944/preprints202002.0250.v1 preprint EN 2020-02-17

Abstract The connection between stress-induced mood disorders and inflammatory bowel diseases has long been acknowledged. Here, we hypothesize that psychological stress may regulate intestinal inflammation under conditions through the release of small extracellular vesicles derived from astrocytes (AsEVs). Sprague-Dawley rats were stressed by movement restriction. In-utero electroporation was performed to express a recombinant protein (BAP-TM) in is exported AsEVs. AsEVs also obtained...

10.21203/rs.3.rs-3756093/v1 preprint EN cc-by Research Square (Research Square) 2024-01-12

As speech generation technology advances, so do the potential threats of misusing spoofed signals. One way to address these is by attributing signals their source generative model. In this work, we are first tackle single-model attribution task in an open-world setting, that is, aim at identifying whether from unknown sources originate a specific vocoder. We show standardized average residual between audio and low-pass filtered or EnCodec versions can serve as powerful vocoder fingerprints....

10.48550/arxiv.2411.14013 preprint EN arXiv (Cornell University) 2024-11-21

Abstract Emerging evidence highlights the relevance of protein post-translational modification by SUMO (Small Ubiquitin-like Modifier) in central nervous system for modulating cognition and plasticity health disease. In these processes, astrocyte-to-neuron crosstalk mediated extracellular vesicles (EVs) plays a yet poorly understood role. Small EVs (sEVs), including microvesicles exosomes, contain molecular cargo lipids, proteins, nucleic acids that define their biological effect on target...

10.21203/rs.3.rs-3193222/v1 preprint EN cc-by Research Square (Research Square) 2023-07-27

Emerging evidence highlights the relevance of protein post-translational modification by SUMO (Small Ubiquitin-like Modifier) in central nervous system for modulating cognition and plasticity health disease. In these processes, astrocyte-to-neuron crosstalk mediated extracellular vesicles (EVs) plays a yet poorly understood role. Small EVs (sEVs), including microvesicles exosomes, contain molecular cargo lipids, proteins, nucleic acids that define their biological effect on target cells....

10.2139/ssrn.4575334 preprint EN 2023-01-01

In the past few years, it has been shown that deep learning systems are highly vulnerable under attacks with adversarial examples.Neural-network-based automatic speech recognition (ASR) no exception.Targeted and untargeted can modify an audio input signal in such a way humans still recognise same words, while ASR steered to predict different transcription.In this paper, we propose defense mechanism against targeted consisting removing fast-changing features from signals, either by applying...

10.21437/spsc.2021-8 preprint EN 2021-11-03
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