A5084069241- Inflammasome and immune disorders
- Immune Response and Inflammation
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Inflammation biomarkers and pathways
- Mechanical Circulatory Support Devices
- Complement system in diseases
- Cancer-related molecular mechanisms research
- Biomarkers in Disease Mechanisms
- Parasites and Host Interactions
- Neonatal Respiratory Health Research
- Cell death mechanisms and regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Immune responses and vaccinations
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Hepatitis Viruses Studies and Epidemiology
- Immune cells in cancer
- Long-Term Effects of COVID-19
Jena University Hospital
2018-2024
Al-Azhar University
2023
Complement factor C5a was originally identified as a powerful promoter of inflammation through activation the receptor 1 (C5ar1). Recent evidence suggests involvement not only in pro- but also anti-inflammatory signaling. The present study aims to unveil role C5ar1 potential therapeutic target murine sepsis model. Our discloses significantly increased survival models mild moderate severe C5ar1-deficient mice. decreased mortality mice is accompanied by improved pathogen clearance and largely...
The non-canonical inflammasome, which includes caspase-11 in mice and caspase-4 caspase-5 humans, is upregulated during inflammatory processes activated response to bacterial infections carry out pyroptosis. Inadequate activity of the inflammasome has been associated with states immunosuppression immunopathological organ damage. However, regulation receptors severe largely not understood. We report that CASP4 CASP5 are differentially regulated acute-on-chronic liver failure sepsis-associated...
TLRs mediate the recognition of microbial and endogenous insults to orchestrate inflammatory response. localize plasma membrane or endomembranes, depending on member, rely critically ER-resident chaperones mature reach their subcellular destinations. The chaperone canopy FGF signaling regulator 3 (CNPY3) is necessary for proper trafficking multiple including TLR1/2/4/5/9 but not TLR3. However, exact role CNPY3 in signalling downstream has been studied detail. Consistent with reported client...
Background & aimsGut bacterial translocation contributes to immune dysfunction and spontaneous peritonitis (SBP) in cirrhosis. We hypothesized that exposure of peritoneal macrophages (PMs) DNA results type-I interferon (IFN) production, shaping subsequent responses, inflammasome activation, the release damage-associated molecular patterns (DAMPs).MethodsPMs from patients with cirrhosis were stimulated E. coli single-stranded (ssDNA), lipopolysaccharide LPS, IFN or infected coli, S. aureus,...
Abstract Background & Aims Necroptosis facilitates cell death in a controlled manner and is employed by many types following injury. It plays major role various liver diseases, albeit the type-specific regulation of necroptosis especially hepatocytes has not yet been conceptualized. Approaches Results Here, we demonstrate that DNA methylation suppresses RIPK3 expression human HepG2 cells. In diseases leading to cholestasis induced mice humans cell-type specific manner. Over-expression...
<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic, systemic disorder characterized by the presence of many proinflammatory cytokines that have been involved in pathogenesis, comorbidity, and premature mortality, due to increased atherosclerotic heart disease[1]. homocysteinemia an independent risk factor for coronary disease, stroke, predictor cardiovascular mortality patients.[2] leptin component mediates immune response plays important role T-cell related inflammatory process.[3]...
Background Diagnosis of neonatal sepsis is complicated due to limited accuracy biochemical, microbiological and phenotypic parameters infection. Hence, early recognition fundamental in reducing the risk sepsis-related diseases mortality. As part innate immune defense mechanisms, inflammasomes sense exogen endogen danger signals thereby effecting secretion inflammatory mediators as well cell death. We first evaluated inflammasome-dependent alarmins Galectin-1 (Gal-1), progranulin (PGRN)...
ABSTRACT Molecular mechanisms through which Gram-positive bacteria induce the canonical inflammasome are poorly understood. Here, we studied effects of Group B streptococci (GBS) and Staphylococcus aureus (SA) on activation in human macrophages. Dinucleotide binding small RNA aptamers released by SA GBS were shown to trigger increased IL-1β generation inflammasomes. The stimulator interferon genes-STING as a central mediator innate immune responses has been identified key target pathogenic...