A5050133556- Immune Cell Function and Interaction
- interferon and immune responses
- RNA regulation and disease
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Microfluidic and Capillary Electrophoresis Applications
- Electrowetting and Microfluidic Technologies
- Lipid Membrane Structure and Behavior
- Cytomegalovirus and herpesvirus research
- CRISPR and Genetic Engineering
- Biosensors and Analytical Detection
- Virus-based gene therapy research
- CAR-T cell therapy research
- Cancer, Lipids, and Metabolism
- T-cell and B-cell Immunology
- HIV Research and Treatment
University Medical Center Groningen
2023
Integrated BioTherapeutics (United States)
2023
Canada's Michael Smith Genome Sciences Centre
2022
University of British Columbia
2022
Vietnam National University Ho Chi Minh City
2020
Lipid nanoparticles (LNPs) are the leading technology for RNA delivery, given success of Pfizer/BioNTech and Moderna COVID-19 mRNA (mRNA) vaccines, small interfering (siRNA) therapies (patisiran). However, optimization LNP process parameters compositions larger payloads such as self-amplifying (saRNA), which can have complex secondary structures, not been carried out. Furthermore, interactions between parameters, critical quality attributes (CQAs), function, protein expression cellular...
Overexpression of repetitive elements is an emerging hallmark human cancers 1 . Diverse repeats can mimic viruses by replicating within the cancer genome through retrotransposition, or presenting pathogen-associated molecular patterns (PAMPs) to pattern recognition receptors (PRRs) innate immune system 2-5 Yet, how specific affect tumor evolution and shape microenvironment (TME) in a pro- anti-tumorigenic manner remains poorly defined. Here, we integrate whole total transcriptome data from...
ABSTRACT An emerging hallmark across human diseases – such as cancer, autoimmune and neurodegenerative disorders is the aberrant transcription of typically silenced repetitive elements. Once active, a subset repeats may be capable “viral mimicry”: display pathogen-associated molecular patterns (PAMPs) that can, in principle, bind pattern recognition receptors (PRRs) innate immune system trigger inflammation. Yet how to quantify landscape viral mimicry it shaped by natural selection remains...
Abstract Regulatory T cells (Tregs) are potent immune suppressors and critical to the maintenance of immunological tolerance. Interleukin 2 (IL-2) is essential for Treg survival, expansion, phenotypic stability, suppressive function. However, Tregs do not produce IL-2 dependent on exogenous sources IL-2. This poses a significant challenge cell therapies in tissues with no or limited availability microenvironment. Therefore, we have developed engineered containing chimeric cytokine receptor...