A5055472749- Clostridium difficile and Clostridium perfringens research
- Luminescence Properties of Advanced Materials
- Microscopic Colitis
- Glass properties and applications
- Gut microbiota and health
- Microwave Dielectric Ceramics Synthesis
- Solid State Laser Technologies
- Antimicrobial Resistance in Staphylococcus
- Helicobacter pylori-related gastroenterology studies
- Nuclear materials and radiation effects
- Nosocomial Infections in ICU
- Electronic and Structural Properties of Oxides
- Cancer Genomics and Diagnostics
- Advanced Condensed Matter Physics
- Diabetes and associated disorders
- Cancer Immunotherapy and Biomarkers
- Pancreatic function and diabetes
- Pancreatitis Pathology and Treatment
- Cultural Heritage Management and Preservation
- Ga2O3 and related materials
- Radiation Detection and Scintillator Technologies
- Pancreatic and Hepatic Oncology Research
- Bacterial Identification and Susceptibility Testing
- Viral gastroenteritis research and epidemiology
- Aquatic and Environmental Studies
Ruijin Hospital
2011-2024
Shanghai Jiao Tong University
2011-2024
Shanghai University
2013-2017
Beijing International Studies University
2010
Clostridioides difficile is a pathogen contributing to increased morbidity and mortality of patients with inflammatory bowel disease (IBD). To determine how C. affects the severity colitis, we constructed dextran sulfate solution-induced colitis model challenged difficile. Without antibiotic administration, led transient colonization in mice but still significantly enhanced as assessed by weight loss, histopathological damages, cytokine concentrations. Because this effect independent toxin...
Infectious complications (ICs) in acute pancreatitis (AP) are primarily driven by intestinal bacterial translocation, significantly increasing mortality and hospital stays. Despite this, the role of gut microenvironment, particularly its metabolic aspects, AP remains poorly understood. In this study, we investigated a cohort patients with AP, conducted supplemental murine studies, to explore relationship between metabolome development ICs. Metabolomic analysis revealed that disruptions...
Intestinal colonization by pathogenic bacteria is a risk factor for infection, and contributes to environmental contamination disease dissemination. Alteration of gut microbiota also plays pivotal role in the development disease. Although Clostridium difficile Staphylococcus aureus are well-recognized pathogens causing nosocomial community infections, intestinal was not fully investigated. Herein, we explored their overall carriage rates healthy adults from community, characterized...
Despite many studies focusing on the prognostic biomarkers in pancreatic adenocarcinomas (PAADs), there is ill-informed about relationships between their genomic features and immune characteristics. Herein, we deeply investigated involvement of major driver mutation subtypes with immunophenotypes impacting PAAD outcomes. Based public data analyses RNA expression-based PAAD, contrast to KRAS G12D & TP53 co-mutant patients poor outcomes, best subtype C3 (inflammatory) characterized by high...
Clostridioides difficile is considered the main pathogen responsible for hospital-acquired infections. This prospective study determined prevalence, molecular epidemiological characteristics, and risk factors C. infection (CDI) colonization (CDC) among patients in intensive care unit (ICU) of a large-scale tertiary hospital China, with aim providing strategies efficient CDI CDC prevention control.Stool samples were collected anaerobically cultured detection. The identified isolates examined...
Abstract Background Clostridioides difficile infection (CDI) is a leading cause of nosocomial diarrhea. Patients receiving enteral nutrition (EN) in the intensive care unit (ICU) are potentially at high risk CDI. In present study, we assessed factors and intestinal microbiome patients to better understand occurrence development Methods were screened for C. every week after starting EN, their clinical records collected factor identification. Fecal samples analyzed using 16S rRNA sequencing...
Background Over the last decade, Clostridium difficile infection (CDI) has emerged as a significant nosocomial infection, yet little been reported from China. This study aimed to characterize clinical and microbiological features of CDI hospital in Shanghai. Methods Patients with seen between December 2010 March 2013 were included this study, which data retrospectively collected. The corresponding isolates analyzed including genotype by multi-locus sequence typing (MLST), antimicrobial...
Introduction: Clostridium difficile is a common cause of nosocomial diarrhea, especially in elderly patients. This study aimed to analyze the clinical features and assess risk factors associated with infection (CDI) hospitalized Methodology: A retrospective case-control was conducted among patients (> 60 years age) Chinese tertiary hospital between 2010 2013. Fifty-two CDI 150 randomly selected non-CDI were included study. Clinical compared by appropriate statistical tests. Logistic...
Toxin A-negative, toxin B-positive Clostridioides difficile strains, which primarily include the ST81 and ST37 genotypes, are predominant in C. infections leading to antibiotic-associated diarrhea China. Recently, has been reported as most prevalent genotype rather than ST37, although genetic functional characteristics of two genotypes remain ambiguous. In this study, we conducted comprehensive comparative analysis these through complete genome sequencing phenotypic profiling. The whole...
Objective To assess the application value of REP-PCR in genotyping candida glabrata strains clinical pratice. Methods From 2009 to 2010, thirty-eight were isolated from Shanghai Ruijin Hospitals, Renji Hospital, Huashan Anhui Medical University Shenzhen People's Hospital. Six loci housekeeping genes (FKS, LEU2,NMT1, TRP1, UGP1 and URA3 ) amplified sequenced. The sequences compared with MIST database allele profile sequence type (ST) obtained. With primers Ca21, Ca22 Com21 used amplify...