A5062391998- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Hematological disorders and diagnostics
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Blood disorders and treatments
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Erythrocyte Function and Pathophysiology
- Lymphoma Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neutropenia and Cancer Infections
- Immunodeficiency and Autoimmune Disorders
- Metastasis and carcinoma case studies
- PI3K/AKT/mTOR signaling in cancer
- Chronic Lymphocytic Leukemia Research
- Epigenetics and DNA Methylation
- Bone and Joint Diseases
- Medicinal Plants and Neuroprotection
- Sarcoma Diagnosis and Treatment
- Biochemical and Molecular Research
- Pneumocystis jirovecii pneumonia detection and treatment
University of Florence
2019-2025
University of Siena
2024-2025
Azienda Ospedaliero-Universitaria Careggi
2024
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2024
Tumour Institute of Tuscany
2023
Advancements in comprehending myelodysplastic neoplasms (MDS) have unfolded significantly recent years, elucidating a myriad of cellular and molecular underpinnings integral to disease progression. While inclusions into prognostic models substantively advanced risk stratification, revelations emphasized the pivotal role immune dysregulation within bone marrow milieu during MDS evolution. Nonetheless, immunotherapy for has not experienced breakthroughs seen other malignancies, partly...
Abstract We explored the impact of luspatercept therapy on overall survival (OS) and possible predictors response in low‐risk (LR) myelodysplastic syndrome (MDS) patients. evaluated 331 anemic patients treated with luspatercept. Hematological (HI) was defined as (i) hemoglobin (Hb) increase ≥1.5 g/dL nontransfusion‐dependent (NTD) patients, (ii) red blood cell (RBC) transfusion independence (TI) a concomitant Hb g/dL, or RBC‐TI without an 1.5 >50% reduction RBC burden (TB) for TD Response...
Relevance of germline (GL) predisposition in myelodysplastic syndromes (MDSs) was stressed both 2022 WHO and International Consensus classifications, but its incidence is probably underestimated, especially young adult patients. We selected a cohort 31 consecutive de novo MDS patients with unusual age (<60 years). performed exome sequencing (ES) on DNA extracted from noninvasive sources (peripheral blood saliva), filtering for panel 344 genes specifically tailored detecting GL variants...
Abstract Alzheimer's disease (AD) represents an urgent yet unmet challenge for modern society, calling exploration of innovative targets and therapeutic approaches. Astrocytes, main homeostatic cells in the CNS, represent promising cell‐target. Our aim was to investigate if deletion regulatory CaNB1 subunit calcineurin astrocytes could mitigate AD‐related memory deficits, neuropathology, neuroinflammation. We have generated two, acute chronic, AD mouse models with astrocytic ablation...