A5101621724- Circadian rhythm and melatonin
- Retinal Development and Disorders
- Polysaccharides Composition and Applications
- Spaceflight effects on biology
- Skin and Cellular Biology Research
- Memory and Neural Mechanisms
- Ethnobotanical and Medicinal Plants Studies
- Traditional Chinese Medicine Analysis
- Stress Responses and Cortisol
- Neurobiology and Insect Physiology Research
- Identification and Quantification in Food
- Polysaccharides and Plant Cell Walls
- Neuroscience and Neuropharmacology Research
University of Tsukuba
2016-2025
Tsukuba International University
2016-2025
Dali University
2020
The rhizome of Polygonatum kingianum has been used as a traditional medicine in China. In this study, novel polysaccharides (PKPs-1) was isolated from P. and characterized by its molecular weight, primary structure. hypoglycemic activity PKPs-1was investigated vitro assay with the HepG2 cell line vivo test using STZ-induced diabetic mice. Results showed that average weight PKPs-1 14.05 kDa is composed mainly glucose mannose. Methylation analysis indicated fraction consisted β1,2-link...
Abstract The phase response curve (PRC) represents the time-dependent changes in circadian rhythm following internal or external stimuli. However, this time dependence complicates PRC measurement and quantification owing to its variable shape with changing stimulus intensity. Our previous work demonstrated that resetting a desynchronized clock (singularity response, SR) simplifies analysis by requiring only amplitude parameters. In study, we construct comprehensive model for mouse converting...
Many patients with psychiatric conditions, such as bipolar disorder and major depressive disorder, frequently experience disruptions in their sleep–wake cycles. Several case studies clinical trials have shown that the administration of aripiprazole, a commonly prescribed antipsychotic drug, alleviates symptoms circadian sleep disorders these patients. This improvement may be attributed to effects aripiprazole on central clock, specifically hypothalamic suprachiasmatic nucleus (SCN), which...
The conditions under which memory generalization occurs are not well understood. Although it is believed that fear gradually established after learning, clear whether experiences soon learning affect generalization. Using a contextual conditioning paradigm in mice, we found occurred when mice were exposed to familiar, unconditioned context learning. Our results suggest the familiarity of contexts and timing their exposure influences generalization, increases our understanding mechanisms
The purpose of this study was to test the ability DNA barcoding identify herbal raw trade Tibetan medicine Dida in China. A reference database for plant-material barcodes successfully constructed and used 36 commercially samples collected from Southwest ITS sequence amplified these efficiency PCR amplification 100%. sequencing results revealed that 3 (8.3%) were authenticated as Swertia chirayita, 2 sequences (5.6%) mussotii, ciliata, recorded Pharmacopeia. other adulterants all them...