A5113022064- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Photoacoustic and Ultrasonic Imaging
- Optical measurement and interference techniques
- Immune Cell Function and Interaction
- Spectroscopy Techniques in Biomedical and Chemical Research
- Random lasers and scattering media
- Image Processing Techniques and Applications
- Erythrocyte Function and Pathophysiology
- Image Enhancement Techniques
- Image and Signal Denoising Methods
- Melanoma and MAPK Pathways
- T-cell and B-cell Immunology
- Cell death mechanisms and regulation
- Advanced Image Fusion Techniques
- Hippo pathway signaling and YAP/TAZ
- Immune cells in cancer
- Multiple Myeloma Research and Treatments
- Signaling Pathways in Disease
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Optical Imaging and Spectroscopy Techniques
- Metamaterials and Metasurfaces Applications
- Sparse and Compressive Sensing Techniques
Zhejiang University
2023-2025
Broad Institute
2024
Peking University
2023-2024
Harvard University
2024
Massachusetts Institute of Technology
2024
Boston Children's Hospital
2024
Compressive spectral imaging (CSI) enables rapid acquisition of encoded measurements, followed by image reconstruction using compressive sensing algorithms. However, existing CSI systems lack compact, effective encoding designs coupled with fast, high-quality decoding methods. This paper presents a system compact reflective optical path design based on digital micromirror device (DMD), which facilitates additional independent measurements switching DMD patterns, thereby improving accuracy....
Inflammation is an essential defense response but operates at the cost of normal functions. Whether and how negative impact inflammation monitored remains largely unknown. Acidification tissue microenvironment associated with inflammation. Here we investigated whether macrophages sense acidification to adjust inflammatory responses. We found that acidic pH restructured in a gene-specific manner. identified mammalian BRD4 as novel intracellular sensor. Acidic disrupts transcription...
The RVd therapy, combining lenalidomide, bortezomib, and dexamethasone, is a mainstay treatment for multiple myeloma. A myeloma patient developed pure red cell aplasia (PRCA) following treatment, despite the absence of common PRCA triggers. In vitro analyses reveal lenalidomide as pivotal disruptor erythropoiesis. Single-cell transcriptome analysis unveils hyperactive CD8+ T cells impaired erythropoiesis in patient's bone marrow. Unexpectedly, erythroid display abnormally high expression...
Coded aperture snapshot spectral imaging (CASSI) can capture hyperspectral images (HSIs) in one shot, but it suffers from optical aberrations that degrade the reconstruction quality. Existing deep learning methods for CASSI lose some performance on real data due to aberrations. We propose a method restore high-resolution HSIs low-resolution measurement. first generate realistic training mimics of using simulation technique. A generative network is then trained this recover blurred and...
Abstract The Mediator complex regulates various aspects of hematopoietic development, but whether composition the undergoes dynamic changes for diversifying transcription and functional outputs is unknown. Here, we found that MED26, a subunit in core complex, played distinctive role facilitating pausing essential erythroid development. While most subunits drastically decreased during this process, MED26 remained relatively abundant. Intriguingly, early stages, more than half occupancy sites...
Compressed spectral imaging (CSI) typically captures images in a single shot by encoding scenes with mask, but it often neglects information occluded the mask. This paper capitalizes on such overlooked to enhance performance. By integrating sparse mask design, our approach both data and complementary spatial simultaneously. We utilize spatial–spectral dual filtering technique achieve superior reconstruction quality of images. Contrasting conventional dual-camera CSI systems, design combines...
The Mediator complex regulates various aspects of hematopoietic development, but whether composition the undergoes dynamic changes for diversifying transcription and functional outputs is unknown. Here, we found that MED26, a subunit in core complex, played distinctive role facilitating pausing essential erythroid development. While most subunits drastically decreased during this process, MED26 remained relatively abundant. Intriguingly, early stages, more than half occupancy sites did not...
The Mediator complex regulates various aspects of hematopoietic development, but whether composition the undergoes dynamic changes for diversifying transcription and functional outputs is unknown. Here, we found that MED26, a subunit in core complex, played distinctive role facilitating pausing essential erythroid development. While most subunits drastically decreased during this process, MED26 remained relatively abundant. Intriguingly, early stages, more than half occupancy sites did not...
Spectral imaging can obtain spectral information of target scenes and has wide applications many fields such as biomedical, military, agricultural, food safety. Coded aperture snapshot imager (CASSI) proposed a system by employing compressed sensing theory. However, the use dispersion element leads to deviation in direction light propagation, resulting complex system. This paper proposes that utilizes metasurface array instead elements encode spectrum incident uses macro pixel segmentation...
Coded aperture snapshot spectral imaging (CASSI) is a technique that can capture 3D hyperspectral images (HSIs) of scenes in single shot. However, the quality reconstructed HSIs affected by various optical aberrations and system noise. Existing deep learning methods for HSI reconstruction do not consider these degradation patterns thus lack generalization ability to real CASSI data. In this paper, we propose practical method recover high-quality from low-quality We use simulation generate...