A5016821035- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Renin-Angiotensin System Studies
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Apelin-related biomedical research
- Zebrafish Biomedical Research Applications
- Cellular transport and secretion
- MicroRNA in disease regulation
- Neurogenesis and neuroplasticity mechanisms
- Aquaculture disease management and microbiota
- Immune Response and Inflammation
- Hormonal Regulation and Hypertension
- Aquaculture Nutrition and Growth
- Nerve injury and regeneration
Northwestern University
2022-2024
Indiana University Northwest
2019
The current study investigated the independent and combined effects of caffeine taurine on anxiety-like behavior neuroendocrine responses in adult zebrafish (Danio rerio). Caffeine (1,3,7-trimethylpurine-2,6-dione), world's most commonly used psychoactive drug, acts as an adenosine receptor blocker a mild central nervous system stimulant. However, excessive use is associated with heightened anxiety levels. Taurine (2-aminoethanesulfonic acid), semi-essential amino acid synthesized within...
Abstract Background Amyloid plaque deposition and axonal degeneration are early events in AD pathogenesis. Aβ disrupts microtubules presynaptic dystrophic neurites, resulting the accumulation of impaired endolysosomal autophagic organelles transporting β-site amyloid precursor protein cleaving enzyme (BACE1). Consequently, neurites generate Aβ42 significantly contribute to deposition. Farnesyltransferase inhibitors (FTIs) have recently been investigated for repositioning toward treatment...
Abstract Current scientific research is driven by the ability to manipulate gene expression utilizing Cre/loxP system in transgenic mouse models. However, artifacts Cre-driver lines that introduce undesired effects and confound results are increasingly being reported. Here, we show aberrant neuroinflammation synaptic changes two widely used Neuroinflammation CaMKIIα-iCre mice was characterized activation proliferation of microglia astrocytes layers hippocampus. Increased GFAP Iba1 levels...
Angiotensin I converting enzyme (ACE1) maintains blood pressure homeostasis by angiotensin into II in the renin-angiotensin system (RAS). ACE1 is expressed brain, where an intrinsic RAS regulates complex cognitive functions including learning and memory. has been implicated neurodegenerative disorders Alzheimer's disease Parkinson's disease, but mechanisms remain incompletely understood. Here, we performed single-nucleus RNA sequencing to characterize expression of genes hippocampus...
Abstract Angiotensin I converting enzyme (ACE1) maintains blood pressure homeostasis by angiotensin (angI) into II (angII) in the renin-angiotensin system (RAS). ACE1 is expressed brain, where an intrinsic RAS regulates complex cognitive functions including learning and memory. has been implicated neurodegenerative disorders Alzheimer’s disease (AD) Parkinson’s (PD), but mechanisms remain incompletely understood. Here, we performed single-nucleus RNA sequencing to characterize expression...
Alzheimers disease (AD) is the most common form of dementia, and multiple lines evidence support relevance amyloid beta deposition plaque accumulation in neurotoxicity cognitive decline AD. Rare mutations angiotensin converting enzyme 1 (ACE1) have been highly associated with late onset AD patients; however, mechanism for ACE1 mutation pathogenesis unknown. Given strong association abeta to pathogenesis, we investigated whether degrades abeta; affects burden 5XFAD mice vivo. To investigate...
Abstract Current scientific research is driven by the ability to manipulate gene expression utilizing Cre/loxP system in transgenic mouse models. However, artifacts Cre-driver lines that introduce undesired effects and confound results are increasingly being reported. Here, we show aberrant neuroinflammation synaptic changes two widely used Neuroinflammation CaMKIIα-iCre mice was characterized activation proliferation of microglia astrocytes layers hippocampus. Increased GFAP Iba1 levels...