A5089467474- Immunotherapy and Immune Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Oral and Maxillofacial Pathology
- Gut microbiota and health
- interferon and immune responses
- Immune Cell Function and Interaction
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Bone Tumor Diagnosis and Treatments
- Tryptophan and brain disorders
- Endodontics and Root Canal Treatments
Northwestern University
2022-2023
Ludwig-Maximilians-Universität München
2021
Urologische Klinik München
2021
University Hospital Carl Gustav Carus
2020
University of Nis
2018
Centre of Research Excellence in Nutrition and Metabolism
2004
Abstract Background Previous studies show that antibiotic-mediated (abx) alteration of the gut microbiome (GMB) results in a reduction amyloid beta (Aβ) plaques and proinflammatory microglial phenotype male APPPS1-21 mice. However, effect GMB perturbation on astrocyte phenotypes microglial-astrocyte communication context amyloidosis has not been examined. Methods To study whether modulates amyloidosis, female mice were treated with broad-spectrum abx leading to perturbation. GFAP +...
Abstract Conventional dendritic cells (cDC) are key activators of naive T cells, and can be targeted in adults to induce adaptive immunity, but early life considered under-developed or functionally immature. Here we show that, life, when the immune system develops, cDC2 exhibit a dual hematopoietic origin and, like other myeloid lymphoid develop waves. Developmentally distinct despite being distinguishable by fate mapping, transcriptionally similar. adult however, exposed cytokine...
Abstract Current scientific research is driven by the ability to manipulate gene expression utilizing Cre/loxP system in transgenic mouse models. However, artifacts Cre-driver lines that introduce undesired effects and confound results are increasingly being reported. Here, we show aberrant neuroinflammation synaptic changes two widely used Neuroinflammation CaMKIIα-iCre mice was characterized activation proliferation of microglia astrocytes layers hippocampus. Increased GFAP Iba1 levels...
Summary Introduction Cytokine network plays an important role in pathogenesis of chronic periapical lesions. The aim this study was to determine the concentration interleukin-6 (IL-6) tissue homogenates human lesions and correlate its levels with symptomatology size Materials Methods 93 samples were obtained after extraction teeth. Samples divided according clinical presentation as symptomatic asymptomatic, large small. IL-6 analyzed using ELISA. Results Statistically significant difference...
Abstract Although GM-CSF has been widely used in dendritic cell (DC) research, the mechanisms, factors, and signals regulating steady-state differentiation maturation of GM-CSF–dependent DCs are insufficiently known. We found that absence, individually or combined, related proteins DEF6 SWAP-70 strongly enhances murine GM-CSF–derived DCs. Contrasting SWAP-70, control through does not depend on RHOA activation. deficiency leads to expression DC-specific transcription factor ZBTB46 prolonged...
Popovic, J; Savic, D; Vucevic, Pavlovic, V; Vasilijic, S; Gasic, Majstorovic, M; Colic, M Author Information