A5036219600- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- Renal and related cancers
- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- Cancer-related molecular mechanisms research
- Genetic and Kidney Cyst Diseases
- Neurogenesis and neuroplasticity mechanisms
Max Planck Institute of Immunobiology and Epigenetics
2019-2023
University of Freiburg
2019-2023
Since the generation of cell-type specific knockout models, importance inter-cellular communication between neural, vascular, and microglial cells during neural development has been increasingly appreciated. However, extent these major cell populations remains to be systematically mapped. Here, we describe EMBRACE (embryonic brain extraction using FACS), a method simultaneously isolate mural, endothelial, more than 94% purity in ∼4 h. Utilizing isolate, transcriptionally analyze, build...
Members of the NSL histone acetyltransferase complex are involved in multiorgan developmental syndromes. While is known for its importance early development, role fully differentiated cells remains enigmatic. Using a kidney-specific model, we discovered that deletion members KANSL2 or KANSL3 postmitotic podocytes led to catastrophic kidney dysfunction. Systematic comparison two primary cell types reveals as master regulator intraciliary transport genes both dividing and nondividing cells....