A5047754667- TGF-β signaling in diseases
- Osteoarthritis Treatment and Mechanisms
- Periodontal Regeneration and Treatments
- Knee injuries and reconstruction techniques
Saarland University
2018
Application of the chondrogenic transforming growth factor beta (TGF-β) is an attractive approach to enhance intrinsic biological activities in damaged articular cartilage, especially when using direct gene transfer strategies based on clinically relevant recombinant adeno-associated viral (rAAV) vectors.To evaluate ability rAAV-TGF-β construct modulate early repair processes sites focal cartilage injury minipigs vivo relative control (reporter lacZ gene) vector treatment.Controlled...
The continuous presence of TGF-β is critically important to induce effective chondrogenesis. To investigate chondrogenesis in a cartilage defect, we tested the hypothesis that implantation TGF-β1-releasing scaffolds improves very early repair vivo. Spatiotemporal controlled release TGF-β1 was achieved from multiblock were implanted osteochondral defects medial femoral condyles adult minipigs. We observed sustained at 4 wk vivo, which significantly promoted structural aspects overall repair,...