A5061803210- Bacteriophages and microbial interactions
- Viral gastroenteritis research and epidemiology
- Advanced Electron Microscopy Techniques and Applications
- RNA and protein synthesis mechanisms
- Obstructive Sleep Apnea Research
- Genomics and Phylogenetic Studies
- CRISPR and Genetic Engineering
- Autophagy in Disease and Therapy
- Advanced Breast Cancer Therapies
- Laser Applications in Dentistry and Medicine
- Photosynthetic Processes and Mechanisms
- Osteoarthritis Treatment and Mechanisms
- Histone Deacetylase Inhibitors Research
- Antibiotic Resistance in Bacteria
- Cytomegalovirus and herpesvirus research
- Extracellular vesicles in disease
- Cancer, Stress, Anesthesia, and Immune Response
- Antibiotic Use and Resistance
- Diabetic Foot Ulcer Assessment and Management
- Microbial Natural Products and Biosynthesis
- Endoplasmic Reticulum Stress and Disease
- Sirtuins and Resveratrol in Medicine
- Neuroscience of respiration and sleep
- Wound Healing and Treatments
- MicroRNA in disease regulation
Shanghai Jiao Tong University
2015-2025
Xi'an Honghui Hospital
2025
Xi'an Jiaotong University
2025
People's Hospital of Xinjiang Uygur Autonomous Region
2015
Streptomyces antibiotic regulatory proteins (SARPs) are widely distributed activators of biosynthesis. coelicolor AfsR is an SARP regulator with additional nucleotide-binding oligomerization domain (NOD) and a tetratricopeptide repeat (TPR) domain. Here, we present cryo-electron microscopy (cryo-EM) structures in vitro assays to demonstrate how the activates transcription it modulated by NOD TPR domains. The initiation complexes (TICs) show that forms side-by-side dimer simultaneously engage...
Bacterial antiviral STANDs (Avs) are evolutionarily related to the nucleotide-binding oligomerization domain (NOD)-like receptors widely distributed in immune systems across animals and plants. EfAvs5, a type 5 Avs from Escherichia fergusonii, contains an N-terminal SIR2 effector domain, NOD, C-terminal sensor conferring protection against diverse phage invasions. Despite established roles of STAND prokaryotic eukaryotic immunity, mechanism underlying their collaboration remains unclear....
SUMMARY Nursing homes (NHs) have been implicated as significant reservoirs of antibiotic-resistant organisms causing severe infectious disease. We investigated the prevalence and molecular epidemiology of, risk factors for, faecal carriage extended-spectrum β -lactamase-producing Enterobacteriaceae (ESBL-E). A multicentre cross-sectional study was conducted in seven NHs Shanghai between March 2014 May 2014. Antimicrobial susceptibility testing polymerase chain reaction were used to detect...
Recent data have indicated that inflammation may an important correlation with obstructive sleep apnea (OSA). Studies a relationship between OSA and TNF-α gene polymorphisms. Zinc finger protein 36 (ZFP36) regulates mRNAs. However, ZFP36 polymorphisms not been investigated in OSA. Therefore, we conducted the present case-control study to assess whether variances account for differences levels patients moderate-to-severe This aims investigate genetic variations Three common single nucleotide...
Abstract The signal transduction ATPases with numerous domains (STAND) superfamily encompasses widely distributed immune systems across bacteria, eukaryotes and archaea. bacterial antiviral STAND type 5 (Avs5) contains an N-terminal Sirtuin (SIR2) domain, which protects against phage invasion. Despite the established roles of SIR2 in prokaryotic eukaryotic immunity, mechanism underlying their collaboration remains unclear. Here we present cryo-EM structures Escherichia fergusonii Avs5 ( Ef...
<title>Abstract</title> Bacterial antiviral STANDs (Avs) are evolutionarily related to the nucleotide-binding leucine-rich repeat containing receptors (NLRs) widely distributed in immune systems across animals and plants. <italic>Ef</italic>Avs5, an Avs type 5 protein from <italic>Escherichia fergusonii</italic>, contains N-terminal SIR2 effector domain, a oligomerization domain (NOD) C-terminal sensor conferring protection against diverse phage invasions. Despite established roles of STAND...