A5017790276- Plant Pathogens and Fungal Diseases
- Plant-Microbe Interactions and Immunity
- Plant Pathogenic Bacteria Studies
- Plant Disease Resistance and Genetics
- Plant and Fungal Interactions Research
- Wheat and Barley Genetics and Pathology
- Plant Pathogens and Resistance
- Powdery Mildew Fungal Diseases
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Transgenic Plants and Applications
- Polyamine Metabolism and Applications
- Education Methods and Technologies
- Sports Science and Education
- Visual perception and processing mechanisms
- Enzyme Structure and Function
- Psychology, Coaching, and Therapy
- Plant Reproductive Biology
- Plant Virus Research Studies
- Plant pathogens and resistance mechanisms
RWTH Aachen University
2019-2024
Max Planck Institute for Plant Breeding Research
2021-2024
Hertie Institute for Clinical Brain Research
2016
Abstract Nucleotide-binding leucine-rich repeat (NLR) proteins play a pivotal role in plant immunity by recognizing pathogen effectors 1,2 . Maintaining balanced immune response is crucial, as excessive NLR expression can lead to unintended autoimmunity 3,4 Unlike most NLRs, the required for cell death 2 (NRC2) belongs small group characterized constitutively high without self-activation 5 The mechanisms underlying NRC2 autoinhibition and activation are not yet understood. Here we show that...
Nucleotide-binding domain and leucine-rich repeat (NLR)-containing proteins in plants animals mediate intracellular pathogen sensing. Plant NLRs typically detect strain-specific effectors trigger immune responses often linked to localized host cell death. The barley Mla disease resistance locus has undergone extensive functional diversification the population encodes numerous allelic each detecting a matching isolate-specific avirulence effector (AVRA) of fungal Blumeria graminis f. sp....
In plants, host-pathogen coevolution often manifests in reciprocal, adaptive genetic changes through variations host nucleotide-binding leucine-rich repeat immune receptors (NLRs) and virulence-promoting pathogen effectors. grass powdery mildew (PM) fungi, an extreme expansion of a RNase-like effector family, termed RALPH, dominates the repertoire, with some members recognized as avirulence (AVR) effectors by cereal NLR receptors. We report structures sequence-unrelated barley PM AVR
The genome of the obligate biotrophic phytopathogenic barley powdery mildew fungus Blumeria hordei is inflated due to highly abundant and possibly active transposable elements (TEs). In absence otherwise common repeat-induced point mutation transposon defense mechanism, noncoding RNAs could be key for regulating activity TEs coding genes during pathogenic life cycle.We performed time-course whole-transcriptome shotgun sequencing (RNA-seq) total RNA derived from infected leaf epidermis at...
While perceptual learning increases objective sensitivity, the effects on constant interaction of process perception and its metacognitive evaluation have been rarely investigated. Visual has described as a probabilistic inference featuring evaluations choice certainty. For visual motion in healthy, naive human subjects here we show that sensitivity confidence it increased with training. The sensitivity-estimated from certainty ratings by bias-free signal detection theoretic approach-in...
Summary Hosts and pathogens typically engage in a coevolutionary arms race. This also applies to phytopathogenic powdery mildew fungi, which can rapidly overcome plant resistance perform host jumps. Using experimental evolution, we show that the pathogen Blumeria hordei is capable of breaking agriculturally important broad‐spectrum conditioned by barley loss‐of‐function mlo mutants. Partial virulence evolved B. isolates correlated with distinctive pattern adaptive mutations, including...
Summary The barley Mla locus contains functionally diversified genes that encode intracellular nucleotide‐binding leucine‐rich repeat receptors (NLRs) and confer strain‐specific immunity to biotrophic hemibiotrophic fungal pathogens. In this study, we isolated a gene Scs6 , which is an allelic variant of but confers susceptibility the isolate ND90Pr ( Bs ) necrotrophic fungus Bipolaris sorokiniana . We generated transgenic lines showed sufficient in genotypes naturally lacking receptor....
Abstract The genome of the obligate biotrophic phytopathogenic barley powdery mildew fungus Blumeria hordei is inflated due to highly abundant and possibly active transposable elements (TEs). In absence otherwise common repeat-induced point mutation transposon defense mechanism, noncoding RNAs could be key for regulating activity TEs coding genes during pathogenic life cycle. We performed time-course whole-transcriptome shotgun sequencing (RNA-seq) total RNA derived from infected leaf...
Abstract In plants, host–pathogen coevolution often manifests in reciprocal, adaptive genetic changes through variations host nucleotide-binding leucine-rich repeat immune receptors (NLR) and virulence-promoting pathogen effectors. grass powdery mildew (PM) fungi, an extreme expansion of a RNase-like effector family, termed RALPH, dominates the repertoire, with some members recognized as avirulence (AVR) effectors by cereal NLR receptors. We report structures sequence-unrelated barley PM AVR...
Abstract The evolutionary history of plant interactions with necrotrophic pathogens that feed on dying host cells and their virulence mechanisms remains fragmentary. We have isolated the barley gene Scs6 , which is required for fungus Bipolaris sorokiniana isolate ND90Pr to cause spot blotch disease. located at disease resistance locus Mildew a ( Mla ) encodes an intracellular nucleotide-binding leucine-rich repeat receptor (NLR). In transgenic barley, sufficient confer susceptibility in...
Hosts and pathogens typically engage in a co-evolutionary arms race. This also applies to phytopathogenic powdery mildew fungi, which can rapidly overcome plant resistance perform host jumps. Using experimental evolution, we show that the pathogen Blumeria hordei is capable of breaking agriculturally important broad-spectrum conditioned by barley loss-of-function mlo mutants. Partial virulence evolved B. isolates correlated with distinctive pattern adaptive mutations, including small-sized...