A5056643798- DNA Repair Mechanisms
- Lysosomal Storage Disorders Research
- Soybean genetics and cultivation
- Acute Myeloid Leukemia Research
- CRISPR and Genetic Engineering
- Complement system in diseases
- IL-33, ST2, and ILC Pathways
- Calcium signaling and nucleotide metabolism
- Plant pathogens and resistance mechanisms
- Legume Nitrogen Fixing Symbiosis
- Parasitic Infections and Diagnostics
- Toxoplasma gondii Research Studies
- Parasites and Host Interactions
- Eosinophilic Esophagitis
- Rice Cultivation and Yield Improvement
- Glycosylation and Glycoproteins Research
- Plant Reproductive Biology
- Genetics and Plant Breeding
- Genetic Mapping and Diversity in Plants and Animals
- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Plant responses to elevated CO2
- Plant responses to water stress
- Nematode management and characterization studies
- Tryptophan and brain disorders
University of Agriculture Faisalabad
2023
National Institute for Biotechnology and Genetic Engineering
2023
Pakistan Institute of Engineering and Applied Sciences
2023
Cincinnati Children's Hospital Medical Center
2006-2022
University of Cincinnati Medical Center
2012
University of Cincinnati
2010
The University of Texas at San Antonio
2005
Post Graduate Institute of Medical Education and Research
2001
The molecular mechanisms that drive mucosal T helper type 2 (T(H)2) responses against parasitic helminths and allergens remain unclear. In this study, we demonstrate in mice TFF2 (trefoil factor 2), an epithelial cell-derived repair molecule, is needed for the control of lung injury caused by hookworm parasite Nippostrongylus brasiliensis immunity after infection. also necessary rapid production IL-33, a T(H)2-promoting cytokine, epithelia, alveolar macrophages, inflammatory dendritic cells...
The molecular pathogenesis of the myeloid leukemias that frequently occur in patients with Fanconi anemia (FA) is not well defined. Hematopoietic stem cells bearing inactivating mutations FA complementation group C (FANCC) are genetically unstable and hypersensitive to apoptotic cytokine cues including IFN-gamma TNF-alpha, but neoplastic cell clones arise vivo resistant these cytokines. Reasoning combination genetic instability hypersensitivity might create an environment supporting...
Abstract Mϕs promote tissue injury or repair depending on their activation status and the local cytokine milieu. It remains unclear whether immunosuppressive effects of transforming growth factor β (TGF‐β) serve a nonredundant role in Mϕ function vivo. We generated Mϕ‐specific transgenic mice that express truncated TGF‐β receptor II under control CD68 promoter (CD68TGF‐βDNRII) subjected these to dextran sodium sulfate (DSS) model colitis. CD68TGF‐βDNRII have an impaired ability resolve...
The soybean yield is a complex quantitative trait that significantly influenced by environmental factors. G × E interaction (GEI), which derives the performance of genotypes differentially in various conditions, one main obstacles to increasing net production. primary goal this study identify outperforming different latitudes, can then be used future breeding programs. A total 96 were examined two ecological regions: Faisalabad and Tando Jam Pakistan. evaluation conditions showed substantial...
Soybean (Glycine max) is an important legume that used to fulfill the need of protein and oil large number population across world. There are numbers soybean germplasm present in USDA resources. Finding understanding genetically diverse a top priority for crop improvement programs. The current study 20 functional EST-SSR 80 SSR markers characterize 96 accessions from geographic backgrounds. Ninety-six 100 were polymorphic, with 262 alleles (average 2.79 per locus). molecular had average...
Patients with the genomic instability syndrome Fanconi anemia (FA) commonly develop progressive bone marrow (BM) failure and have a high risk of cancer. Certain manifestations disease suggest that FA immune system is dysfunctional may contribute to pathogenesis both BM malignancies. In this study, we investigated inflammation innate immunity in hemopoietic cells using mice deficient complementation group C gene (Fancc). We demonstrate Fancc-deficient exhibit enhanced inflammatory response...
Nucleophosmin (NPM) is a multifunctional protein frequently overexpressed in actively proliferating cells. Strong evidence indicates that NPM required for embryonic development and genomic stability. Here we report enhances the proliferative potential of hematopoietic stem cells (HSCs) increases their survival upon stress challenge. Both short term liquid culture clonogenic progenitor cell assays show selective expansion NPM-overexpressing HSCs. Interestingly, HSCs infected with retrovirus...
Abstract Members of the Fanconi anemia (FA) protein family are involved in repair genetic damage caused by DNA cross-linkers. It is not clear whether FA proteins function oxidative and oncogenic stress response. Here, we report that deficiency Fanca gene mice elicits a p53-dependent growth arrest response to stress. Using Fanca−/−Trp53−/− double knockout model functionally switchable p53 retrovirus, define kinetics, dependence, persistence p53-mediated stresses Fanca−/− cells. Notably,...
The balance between alternatively activated macrophages (AAMs)/M2 cells and classically (M1 cells) is largely dependent on the effects of IL-4 interferon (IFN)-γ, respectively. Although AAM/M2 can suppress inflammation repair damaged tissue, M1 produce an array pro-inflammatory molecules. Macrophage effector functions are critical for host protection against many infectious diseases, but it remains unknown whether lethal immunopathological characteristics, caused by Schistosoma mansoni...
IL-12-mediated type 1 inflammation confers host protection against the parasitic protozoan Toxoplasma gondii. However, production of IFN-γ, another inflammatory cytokine, also drives lethality from excessive injury to intestinal epithelium. As mechanisms that restore epithelial barrier function following infection remain poorly understood, this study investigated role trefoil factor 2 (TFF2), a well-established regulator mucosal tissue repair. Paradoxically, TFF2 antagonized IL-12 release...
Soybean ( Glycine max [L.] Merr.) is one of the most significant crops in world terms oil and protein. Owing to rising demand for soybean products, there an increasing need improved varieties more productive farming. However, complex correlation patterns among quantitative traits along with genetic interactions pose a challenge breeding. Association studies play important role identification accession useful alleles by locating genomic sites associated phenotype germplasm collections. In...
Soil salinity is one of the most devastating environmental stresses, causing a significant reduction in cultivable land worldwide.Salinity restricts growth, development, and yield plants.In response to salinity, plants alter their morpho-physiological, biochemical molecular responses.Under salt stress, plants, including wheat, employ variety biochemical, metabolic changes at cellular, tissue, whole-plant levels survive.Although progress has been made understanding mechanism tolerance there...
Transforming growth factor β (TGF-β) regulates inflammation, immunosuppression, and wound-healing cascades, but it remains unclear whether any of these functions involve regulation myeloid cell function. The present study demonstrates that selective deletion TGF-βRII expression in phagocytes i) impairs macrophage-mediated suppressor activity, ii) increases baseline mRNA proinflammatory chemokines/cytokines the lung, iii) enhances type 2 immunity against hookworm parasite Nippostrongylus...
Abstract Super Basmati is an elite variety with extra-long grains and superior quality but its yield severely affected by water stress. Recombinant inbred lines (RILs) developed from the cross of IR55419-04 (a coarse grained high potential) were used to identify map yield-related quantitative trait loci (QTLs) under normal field conditions. Genotypes for 244 KASP markers obtained 188 F 9 RILs a linkage constructed 1369.4 cM, average marker interval 10.5 cM. Eleven agronomic traits phenotyped...
Gaucher disease is a lysosomal storage disease, which happens due to mutations in GBA1/Gba1 that encodes the enzyme termed as acid β-glucosidase. The major function of this catalyze glucosylceramide (GC) into glucose and ceramide. deficiency resultant abnormal accumulation GC cause altered several innate adaptive immune cells. For example, augmented infiltration T cells contributes increased production pro-inflammatory cytokines, (e.g., IFNγ, TNFα, IL6, IL12p40, IL12p70, IL23, IL17A/F). This...