A5088248987- Neuroinflammation and Neurodegeneration Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- S100 Proteins and Annexins
- Cell Adhesion Molecules Research
- Long-Term Effects of COVID-19
- Protease and Inhibitor Mechanisms
- Adenosine and Purinergic Signaling
- Restless Legs Syndrome Research
- Immune Response and Inflammation
- Angiogenesis and VEGF in Cancer
- Immune Cell Function and Interaction
- Complement system in diseases
- Pharmacological Receptor Mechanisms and Effects
- Atherosclerosis and Cardiovascular Diseases
- Sleep and Wakefulness Research
University of Insubria
2014-2024
Abstract This study tests the hypothesis that in isolated human polymorphonuclear leukocytes (PMN) adrenergic ligands can affect neutrophil extracellular trap (NET) formation. We have previously shown that, PMN, adrenaline (A), through activation of receptors (AR), reduces stimulus-dependent cell activation; we have, therefore, planned to investigate if AR are involved NET production. PMN were obtained from venous blood healthy subject. The ability reactive oxygen species (ROS) production,...
Cyclic RGD peptidomimetics containing a bifunctional diketopiperazine scaffold are novel class of high-affinity ligands for the integrins αVβ3 and αVβ5. Since promising target modulation normal pathological angiogenesis, present study aimed at characterizing ability peptidomimetic cyclo[DKP-RGD] 1 proliferation, migration network formation in human umbilical vein endothelial cells (HUVEC).
Dopamine (DA) affects immune functions in healthy subjects (HS) and during disease by acting on D1-like (D1 D5) D2-like (D2, D3 D4) dopaminergic receptors (DR); however, its effects human polymorphonuclear leukocytes (PMN) are still poorly defined. We investigated DR expression PMN the ability of DA to affect cell migration reactive oxygen species (ROS) production. Experiments were performed cells from HS patients (Pts) with bacterial infections as well, acute phase after recovery. Some...
Objectives COVID-19 lockdowns were introduced to control the pandemic, however, they resulted in a global disruption of daily life and individual health. Reduced accessibility health services, unavailability food drugs, mental challenges had huge impact on older people living with disabling conditions such as Parkinson's disease (PD). We assessed whether what extent more disabled vulnerable (PwP) affected by lockdowns.
Aim: Early biomarkers of phenoconversion to neurodegeneration are crucial identify individuals at high risk. In patients with idiopathic REM sleep behavior disorder (iRBD), the strongest risk factor for neurodegeneration, CD4+ T cells exhibit a peculiar transcription pattern.