A system for direct pharmacologic control of protein secretion was developed to allow rapid and pulsatile delivery therapeutic proteins. engineered so that it accumulated as aggregates in the endoplasmic reticulum. Secretion then stimulated by a synthetic small-molecule drug induces disaggregation. Rapid transient growth hormone insulin achieved vitro vivo. regulated pulse resulted correction serum glucose concentrations mouse model hyperglycemia. This approach may make gene therapy viable...

Effective delivery of secreted proteins by gene therapy will require a vector that directs stable transgene and regulatory system permits pharmacologic control over the level kinetics therapeutic protein expression. We previously described enables transcription target to be controlled rapamycin, an orally bioavailable drug. Here we demonstrate in vivo regulation expression after intramuscular injection two separate adenovirus or adeno-associated virus (AAV) vectors, one encoding inducible...

Chiral materials, similarly to human hands, have distinguishable right-handed and left-handed enantiomers which may behave differently in response external stimuli. Here, we use for the first time an approach based on density functional theory (DFT)+PAOFLOW calculations quantitatively estimate so-called collinear Rashba-Edelstein effect (REE) that generates spin accumulation parallel charge current can manifest as chirality-dependent charge-to-spin conversion chiral crystals. Importantly,...

Studies of structure-property relationships in spintronics are essential for the design materials that can fill specific roles devices. For example, with low symmetry allow unconventional configurations charge-to-spin conversion, which be used to generate efficient spin-orbit torques. Here, we explore relationship between crystal and geometry Rashba-Edelstein effect (REE) causes spin accumulation response an applied electric current. Based on a analysis performed 230 crystallographic space...

Abstract The discovery and realization of topological insulators, a phase matter which hosts metallic boundary states when the d -dimension insulating bulk is confined to ( − 1)-dimensions, led several potential applications. Recently, it was shown that protected can manifest in 2)-dimensions, such as hinge corner for three- two-dimensional systems, respectively. These nontrivial materials are named higher-order insulators (HOTIs). Here we show connection between spin Hall effect HOTIs using...

Crystals with complicated geometry are often observed mixed chemical occupancy among Wyckoff sites, presenting a unique challenge for accurate atomic modeling. Similar systems possessing exact on all the sites can exhibit superstructural ordering, dramatically inflating unit cell size. In this work, crystal graph convolutional neural network (CGCNN) is used to predict optimal decorations fixed crystalline geometries. This achieved site permutation search (SPS) optimization algorithm based...

We present minimal depth circuits implementing the variational quantum eigensolver algorithm and successfully use it to compute band structure of silicon on a machine for first time.

The zinc–antimony phase space has been heavily investigated due to the structural complexity and abundance of high-performing thermoelectric materials. Consequentially, desire use zinc antimony as framework elements encage rattling cations achieve phonon-glass-electron-crystal-type properties remained an enticing goal with only two alkali metal clathrates date, Cs8Zn18Sb28 K58Zn122Sb207. Guided by Zintl electron-counting predictions, we explored Ba–Zn–Pn (Pn = As, Sb) proximal expected...

Efficient generation and manipulation of spin signals in a given material without invoking external magnetism remain one the challenges spintronics. The Hall effect (SHE) Rashba-Edelstein (REE) are well-known mechanisms to electrically generate accumulation materials with strong spin-orbit coupling (SOC), but exact role strength type SOC, especially crystals low symmetry, has yet be explained. In this study, we investigate REE three different families nonmagnetic chiral materials, elemental...

In the interstellar medium, diols and other prebiotic molecules adsorb onto icy mantles surrounding dust grains. Water in ice may affect reactivity photoionization of these diols. Ethylene glycol (EG), 1,2-propylene glycol, 1,3-propylene clusters with water were used as a proxy to study interactions. The diol–water generated continuous supersonic molecular beam, photoionized by synchrotron-based vacuum ultraviolet light from Advanced Light Source, subsequently detected reflectron...

One of the most exciting properties two dimensional materials is their sensitivity to external tuning electronic properties, for example via electric field or strain. Recently discovered analogues phosphorene, group-IV monochalcogenides (MX with M = Ge, Sn and X S, Se, Te), display several interesting phenomena intimately related in-plane strain, such as giant piezoelectricity multiferroicity, which combine ferroelastic ferroelectric properties. Here, using calculations from first...

COVID-19 severity is correlated with granulocyte macrophage colony-stimulating factor (GM-CSF) and C reactive protein (CRP) levels. In the phase three LIVE-AIR trial, lenzilumab an anti-GM-CSF monoclonal antibody, improved likelihood of survival without ventilation (SWOV) in COVID-19, greatest effect participants having baseline CRP below a median 79 mg/L. Herein, utility to guide treatment was assessed.A subanalysis randomised, blinded, controlled, trial which or placebo administered on day...

Spin transistors based on a semiconducting channel attached to ferromagnetic electrodes suffer from fast spin decay and extremely low injection/detection efficiencies. Here, we propose an alternative all-in-one device whose operation principle relies electric manipulation of the lifetime in two-dimensional (2D) SnTe, which sizable Hall effect eliminates need for using ferromagnets. In particular, explore persistent texture (PST) intrinsically present ferroelectric phase protects decoherence...

Quantum computers promise to revolutionize our ability simulate molecules, and cloud-based hardware is becoming increasingly accessible a wide body of researchers. Algorithms such as Phase Estimation the Variational Eigensolver are being actively developed demonstrated in small systems. However, extremely limited qubit count low fidelity seriously limit useful applications, especially crystalline phase, where compact orbital bases difficult develop. To address this difficulty, we present...

The type I clathrate, Ba8Cu16As30, is reinvestigated and found to have a low-temperature polymorph mP108-Ba8Cu16As30 with ordered Cu As sites. In situ temperature-dependent powder X-ray diffraction experiments guided synthetic efforts toward the synthesis of monoclinic (mP108) disordered cubic (cP54) polymorphs high phase purity. While transition from cP54-Ba8Cu16As30 not directly observed, stabilized through quenching temperatures confirmed high-resolution synchrotron diffraction. Combined...

Although the majority of patients with a chronic disease obtain information about their condition from health care professional, medical appointments may not allow sufficient time for educating and addressing questions. Internet resources can fill educational gaps promote knowledge transformation. In 2010 Pew Research Center report, presence increased likelihood that person would search online information. To provide best care, it is important providers are knowledgeable on internet. This...

Two type-I clathrates were synthesized by introducing Ga into the framework of Ba8Cu16P30 clathrate. The introduction minute amounts Ga, 1.9% Ga/Mtotal (where Mtotal = Cu + Ga), resulted in disturbance completely ordered Pbcn superstructure Ba8Cu16P30. Ba8Cu15.43(2)Ga0.3P30.26(3) crystallizes a partially orthorhombic Pmna clathrate-I with five out 15 sites being jointly occupied metal+phosphorus. Increasing content all metal phosphorus archetype cubic Pm3¯n crystal structure...

Background: Little is known about patients’ use of the internet to search for information chronic obstructive pulmonary disease (COPD) and their perspectives on content websites. Objectives: Todetermine interests behavior patients with COPD who