A5021065961- Computational Drug Discovery Methods
- Cancer Genomics and Diagnostics
- Melanoma and MAPK Pathways
- Protein Degradation and Inhibitors
- CRISPR and Genetic Engineering
- CAR-T cell therapy research
- Plant Pathogens and Fungal Diseases
- Hippo pathway signaling and YAP/TAZ
- Colorectal Cancer Treatments and Studies
- Essential Oils and Antimicrobial Activity
- Fluoride Effects and Removal
- Biochemical and Molecular Research
- PARP inhibition in cancer therapy
- Diverse Scientific Research Studies
- Listeria monocytogenes in Food Safety
- Phytase and its Applications
- Galectins and Cancer Biology
- Bioactive Compounds and Antitumor Agents
- Tannin, Tannase and Anticancer Activities
- Genetic factors in colorectal cancer
- Plant-Microbe Interactions and Immunity
- Inflammasome and immune disorders
- Microbial Inactivation Methods
- Protein Tyrosine Phosphatases
- Cancer Cells and Metastasis
NYU Langone Health
2023-2024
Guru Ghasidas Vishwavidyalaya
2024
Hunter Medical Research Institute
2020-2023
University of Technology Sydney
2022
Central Muga Eri Research and Training Institute
2022
Centenary Institute
2020-2022
Advanced Centre for Treatment, Research and Education in Cancer
2021
Tata Memorial Hospital
2021
National Institute of Technology Durgapur
2017-2018
Vellore Institute of Technology University
2013-2016
Abstract Non–small lung cancers (NSCLC) frequently (∼30%) harbor KRAS driver mutations, half of which are KRASG12C. KRAS-mutant NSCLC with comutated STK11 and/or KEAP1 is particularly refractory to conventional, targeted, and immune therapy. Development KRASG12C inhibitors (G12Ci) provided a major therapeutic advance, but resistance still limits their efficacy. To identify genes whose deletion augments efficacy the G12Cis adagrasib (MRTX-849) or plus TNO155 (SHP2i), we performed genome-wide...
KRASG12C inhibitors (adagrasib and sotorasib) have shown clinical promise in targeting KRASG12C-mutated lung cancers; however, most patients eventually develop resistance. In with adenocarcinoma STK11/LKB1 co-mutations, we find an enrichment of the squamous cell carcinoma gene signature pre-treatment biopsies correlates a poor response to adagrasib. Studies Lkb1-deficient KrasG12D cancer mouse models organoids treated KRAS reveal tumors invoke lineage plasticity program, adeno-to-squamous...
A microbial treatment of fluorinated aqueous solution was performed by using a novel bacterial strain isolated from fluoride‐loaded groundwater. Defluoridation efficiencies two forms viz. immobilized live cells and dead biomass the isolate were investigated means series batch studies. Initial fluoride concentration (1–25 mg L −1 ), pH (5–9), bead numbers (5–30), agitation speed (100–240 rpm), temperature (20–45°C) various parameters studied to investigate influence each them on removal...
Abstract Increased inflammasome responses are strongly implicated in inflammatory diseases; however, their specific roles incompletely understood. Therefore, we sought to examine the of nucleotide‐binding oligomerization domain–like receptor (NLR) family, pyrin domain–containing 3 (NLRP3) and absent melanoma‐2 (AIM2) inflammasomes cigarette smoke–induced inflammation a model experimental chronic obstructive pulmonary disease (COPD). We targeted NLRP3 with inhibitor MCC950 given...
Abstract In the present study, we obtained several bacterial isolates from direct plating (without enrichment) of diluted extract apples and oranges commercial market major cities in T amil N adu, I ndia. Based on cultural growth characteristics different selective media, were grouped into four groups. The 16S rRNA gene was amplified using universal primers. expected fragments belonging to two culture groups sequenced. This resulted identification S taphylococcus warneri B acillus pumilis ....
<p>Supplementary Figures 1-7 including Figure legends</p>
<p>Supplementary Figure Legends</p>