A5072489752- Genetic diversity and population structure
- Chromosomal and Genetic Variations
- Plant Reproductive Biology
- Genetic Mapping and Diversity in Plants and Animals
- Evolution and Genetic Dynamics
- Plant and animal studies
- Genomics and Phylogenetic Studies
- Plant Molecular Biology Research
- Plant Taxonomy and Phylogenetics
- Photosynthetic Processes and Mechanisms
- Wheat and Barley Genetics and Pathology
- Plant Virus Research Studies
- Soybean genetics and cultivation
- CRISPR and Genetic Engineering
- Genetic Syndromes and Imprinting
- Plant Disease Resistance and Genetics
- Plant pathogens and resistance mechanisms
- Gene Regulatory Network Analysis
- Legume Nitrogen Fixing Symbiosis
- Agronomic Practices and Intercropping Systems
- Genetic and phenotypic traits in livestock
- Plant Parasitism and Resistance
- Transgenic Plants and Applications
- Epigenetics and DNA Methylation
- Genetically Modified Organisms Research
University of Hohenheim
2022-2025
University of Cologne
2017-2022
Science for Life Laboratory
2014-2021
Stockholm University
2015-2021
Cluster of Excellence on Plant Sciences
2020-2021
Uppsala University
2013-2017
Ludwig-Maximilians-Universität München
2013
Stephen Wright, Detlef Weigel and colleagues report the whole-genome sequence of Capsella rubella, a highly selfing crucifer found throughout much southern western Europe. They compare mixed-stage flower bud transcriptomes from C. rubella grandiflora, finding shift in expression genes associated with flowering phenotypes providing insights into transition to selfing. The outcrossing is common plants1,2, but genomic consequences speed at which they emerge remain poorly understood. An...
Significance Plants have undergone repeated rounds of whole-genome duplication, followed by gene degeneration and loss. Using resequencing, we examined the origins recent tetraploid Capsella bursa-pastoris earliest stages genome evolution after polyploidization. We conclude species had a hybrid origin from two distinct lineages within past 100,000–300,000 y. Our analyses suggest absence rapid loss but provide evidence that has large numbers inactivating mutations, many which were inherited...
Genomic imprinting is an epigenetic phenomenon occurring in mammals and flowering plants that causes genes to adopt a parent-of-origin-specific mode of expression. While the status well conserved mammals, clear estimates for degree conservation were lacking plants. We therefore analyzed genome-wide Capsella rubella, which shared common recent ancestor with Arabidopsis thaliana ∼10 14 million years ago. However, only ∼14% maternally expressed (MEGs) ∼29% paternally (PEGs) C. rubella commonly...
Significance Intermediate outcrossing rates are theoretically predicted to maintain effective selection against harmful alleles, but few studies have empirically tested this prediction with the use of genomic data. We used whole-genome resequencing data from alpine rock-cress study how genetic variation and purifying vary mating system. find that populations intermediate similar levels diversity as populations, alleles is efficient in mixed-mating populations. In contrast, self-fertilizing...
Understanding the causes of cis-regulatory variation is a long-standing aim in evolutionary biology. Although has long been considered important for adaptation, we still have limited understanding selective importance and genomic determinants standing variation. To address these questions, studied prevalence, determinants, forces shaping outcrossing plant Capsella grandiflora We first identified set 1,010 genes with common using analyses allele-specific expression (ASE). Population...
During range expansion, edge populations are expected to face increased genetic drift, which in turn can alter and potentially compromise adaptive dynamics, preventing the removal of deleterious mutations slowing down adaptation. Here, we contrast European subspecies Arabidopsis lyrata ssp. petraea, expanded its Northern after last glaciation. We document a sharp decline effective population size range-edge observe that nonsynonymous variants segregate at higher frequencies. detect 4.9%...
Abstract Tofu is a popular soybean ( Glycine max (L.) Merr.) food with long tradition in Asia and rising popularity worldwide, including Central Europe. Due to the labour-intensive phenotyping procedures, breeding for improved tofu quality challenging. Therefore, our objective was unravel genetic architecture of traits relevant production order assess potential marker-assisted selection genomic these traits. To this end, we performed QTL mapping 188 genotypes from biparental population. The...
The selfing syndrome constitutes a suite of floral and reproductive trait changes that have evolved repeatedly across many evolutionary lineages in response to the shift selfing. Convergent evolution suggests these are adaptive, yet our understanding detailed molecular genetic basis remains limited. Here, we investigate role cis-regulatory during recent Capsella rubella, which split from outcrosser grandiflora less than 200 ka. We assess allele-specific expression (ASE) leaves flower buds at...
Phenotypic plasticity is the variation in phenotype that a single genotype can produce different environments and, as such, an important component of individual fitness. However, whether effect new mutations, and hence evolution, depends on direction remains controversial. Here, we identify cis-acting modifications have reshaped gene expression response to dehydration stress three Arabidopsis species. Our study shows effects most cis-regulatory variants differentiating between A. thaliana...
The rate at which plants grow is a major functional trait in plant ecology. However, little known about its evolution natural populations. Here, we investigate evolutionary and environmental factors shaping variation the growth of Arabidopsis thaliana . We used diameter as proxy to monitor over time environments that mimicked latitudinal differences intensity light radiation, across set 278 genotypes sampled within four broad regions, including an outgroup from China. A field experiment...
The wild tomato species Solanum chilense and S. peruvianum are a valuable non-model system for studying plant adaptation since they grow in diverse environments facing many abiotic constraints. Here we investigate the sequence evolution of regulatory regions drought cold responsive genes their expression regulation. coding these were previously shown to exhibit signatures positive selection. Expression profiles members Asr (ABA/water stress/ripening induced) gene family dehydrin pLC30-15...
A crucial step in the transition from outcrossing to self-fertilization is loss of genetic self-incompatibility (SI). In Brassicaceae, SI involves interaction female and male specificity components, encoded by genes SRK SCR at locus (S-locus). Theory predicts that S-linked mutations, especially dominant mutations SCR, are likely contribute SI. However, few studies have investigated contribution wild plant species. Here, we investigate basis self-fertilizing crucifer species Capsella...
Abstract Polyploidy, or whole-genome duplication, is a common speciation mechanism in plants. An important barrier to polyploid establishment lack of compatible mates. Because self-compatibility alleviates this problem, it has long been hypothesized that there should be an association between polyploidy and (SC), but empirical support for prediction mixed. Here, we investigate whether the molecular makeup Brassicaceae self-incompatibility (SI) system, specifically dominance relationships...
Abstract Rapid advances in short-read DNA sequencing technologies have revolutionized population genomic studies, but there are regions where this technology reaches its limits. Limitations mostly arise due to the difficulties assembly or alignment of high sequence divergence and repeat content, which typical characteristics for loci under strong long-term balancing selection. Studying genetic diversity at such therefore remains challenging. Here, we investigate feasibility error rates...
Abstract During range expansion, edge populations are expected to face increased genetic drift, which in turn can alter and potentially compromise adaptive dynamics, preventing the removal of deleterious mutations slowing down adaptation. Here, we contrast European sub-species Arabidopsis lyrata ssp petraea , expanded its Northern after last glaciation. We document a sharp decline effective population size range-edge observe that non-synonymous variants segregate at higher frequencies....
Wheat is an important staple crop since its proteins contribute to human and animal nutrition are for end-use quality. However, wheat can also cause adverse reactions a large number of people. We performed genome wide association study (GWAS) on 114 quantified by LC-MS-based proteomics expressed in environmentally stable manner 148 cultivars with heritability > 0.6. For 54 proteins, we detected quantitative trait loci (QTL) that exceeded the Bonferroni-corrected significance threshold...
Abstract The formation of an allopolyploid species involves the merger two genomes with separate evolutionary histories. In allopolyploids, genes derived from one progenitor are often expressed at higher levels than those other progenitor. It has been suggested that this could be due to differences in transposable element (TE) content among progenitors, as silencing TEs can affect expression nearby genes. Here, we examine role for biases widespread allotetraploid Capsella bursa-pastoris and...
Abstract Shifts from outcrossing to self-fertilisation have occurred repeatedly in many different lineages of flowering plants, and often involve the breakdown genetic mechanisms. In Brassicaceae, self-incompatibility (SI) allows plants ensure by recognition rejection self-pollen on stigma. This occurs through interaction female male specificity components, consisting a pistil based receptor pollen-coat protein, both which are encoded tightly linked genes at S -locus. When benefits selfing...
Abstract Whole genome duplication events have occurred repeatedly during flowering plant evolution, and there is growing evidence for predictable patterns of gene retention loss following polyploidization. Despite these important insights, the rate processes governing earliest stages diploidization remain poorly understood, relative importance genetic drift, positive selection relaxed purifying in process degeneration unclear. Here, we conduct whole resequencing Capsella bursa-pastoris , a...
Plant mating systems have profound effects on levels and structuring of genetic variation, can affect the impact natural selection. While theory predicts that intermediate outcrossing rates may allow plants to prevent accumulation deleterious alleles, few studies empirically tested this prediction using genomic data. Here, we study effect system purifying selection by conducting population analyses whole-genome resequencing data from 38 European individuals arctic-alpine crucifer Arabis...
Understanding the causes of cis -regulatory variation is a long-standing aim in evolutionary biology. Although has long been considered important for adaptation, we still have limited understanding selective importance and genomic determinants standing variation. To address these questions, studied prevalence, forces shaping outcrossing plant Capsella grandiflora . We first identified set 1,010 genes with common using analyses allele-specific expression (ASE). Population whole-genome...