A5103101383- Evolutionary Game Theory and Cooperation
- Evolution and Genetic Dynamics
- Fatty Acid Research and Health
- Chromosomal and Genetic Variations
- Genetic diversity and population structure
- Plant and animal studies
- Genomics and Phylogenetic Studies
- Plant Reproductive Biology
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Philosophy and History of Science
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Aquaculture Nutrition and Growth
- Plant Virus Research Studies
- Eicosanoids and Hypertension Pharmacology
- Evolutionary Psychology and Human Behavior
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Origins and Evolution of Life
- CRISPR and Genetic Engineering
- Evolution and Science Education
- Metabolomics and Mass Spectrometry Studies
- Cholesterol and Lipid Metabolism
- Aquaculture disease management and microbiota
Cleveland Clinic
2023-2025
Uppsala University
1992-2024
University of Eastern Finland
2014-2024
Cleveland Clinic Lerner College of Medicine
2023-2024
Institut de Biologia Evolutiva
2024
Harvard University
2008-2022
Cornell University
2008-2020
Pediatrics and Genetics
2019
University of Toronto
2010-2016
Kuopio University Hospital
2004-2015
Stephen Wright, Detlef Weigel and colleagues report the whole-genome sequence of Capsella rubella, a highly selfing crucifer found throughout much southern western Europe. They compare mixed-stage flower bud transcriptomes from C. rubella grandiflora, finding shift in expression genes associated with flowering phenotypes providing insights into transition to selfing. The outcrossing is common plants1,2, but genomic consequences speed at which they emerge remain poorly understood. An...
Significance Plants have undergone repeated rounds of whole-genome duplication, followed by gene degeneration and loss. Using resequencing, we examined the origins recent tetraploid Capsella bursa-pastoris earliest stages genome evolution after polyploidization. We conclude species had a hybrid origin from two distinct lineages within past 100,000–300,000 y. Our analyses suggest absence rapid loss but provide evidence that has large numbers inactivating mutations, many which were inherited...
Lower levels of physical activity (PA) and sedentary behaviour (SB) have been associated with increased cardiometabolic risk among children. However, little is known about the independent combined associations PA SB as well different types these behaviours in We therefore investigated relationships children.The subjects were a population sample 468 children 6-8 years age. assessed by questionnaire administered parents validated monitor combining heart rate accelerometry measurements. body...
The roles of polymorphisms the sitosterolemia genes ABCG5 and ABCG8 in regulation cholesterol metabolism insulin sensitivity were studied mildly hypercholesterolemic noncoronary subjects (n = 263, 144 men 119 women) divided into tertiles by baseline serum cholestanol-to-cholesterol ratio (≤118.3 ≥147.7 10<sup>2</sup> × mmol/mol cholesterol), a surrogate marker absorption efficiency. lowest cholestanol tertile was associated with high body mass index (BMI), plasma glucose, triglycerides,...
Despite having predominately deleterious fitness effects, transposable elements (TEs) are major constituents of eukaryote genomes in general and plant particular. Although the proportion genome made up TEs varies at least four-fold across plants, relative importance evolutionary forces shaping variation TE abundance distributions taxa remains unclear. Under several theoretical models, mating system plays an important role governing dynamics TEs. Here, we use recently sequenced Capsella...
BackgroundThe effect of weight loss on different plasma lipid subclasses at the molecular level is unknown. The aim this study was to examine whether a diet-induced reduction result in changes extended profiles (lipidome) subjects with features metabolic syndrome 33-week intervention.Methodology/Principal FindingsPlasma samples 9 group and 10 control were analyzed using mass spectrometry based lipidomic fatty acid analyses. Body decreased by 7.8±2.9% (p<0.01). Most serum triacylglycerols...
Obesity is associated with disturbed lipid metabolism and low-grade inflammation in tissues. The aim of this study was to investigate the association between FA adipose tissue (AT) Kuopio Surgery study. We investigated surgery-induced weight loss desaturase (FADS)1/2 genotypes serum AT profile inflammation, measured as interleukin (IL)-1β NFκB pathway gene expression, order find potential gene-environment interactions. demonstrated an levels saturated polyunsaturated n-6 FAs, estimated...
Comparative phylogenetics provides a wealth of computational tools to understand evolutionary processes and their outcomes. Advances in these methodologies have occurred parallel with surge cross-species genomic phenotypic data. To date, however, the majority published studies focused on classical questions biology, such as speciation ecological drivers trait evolution. Here, we argue that medicine general, our understanding origin diversification disease traits particular, would be greatly...
Sen, Chandan K., Mustafa Atalay, Jyrki Ågren, David E. Laaksonen, Sashwati Roy, and Osmo Hänninen. Fish oil vitamin E supplementation in oxidative stress at rest after physical exercise. J. Appl. Physiol.83(1): 189–195, 1997.—Fish exercise may induce stress. We tested the effects of 8 wk α-tocopherol (vitamin E) fish (FO) on resting exercise-induced Rats ( n = 80) were divided into groups supplemented with FO, FO (FOVE), soy (SO), SO (SOVE), for FOVE SOVE they corresponding (FOVE-Ex...
Abstract Erythrocyte membrane fatty acid (EMFA) composition is used in the validation of food frequency questionnaires (FFQ) and evaluation dietary fat quality. In this cross‐sectional study we aimed to investigate associations diet with EMFA. Altogether, 1,033 randomly selected Finnish men, aged from 47 75 years filled a FFQ their EMFA was analyzed. Marine polyunsaturated (PUFA) intake correlated positively erythrocyte eicosapentaenoic docosahexaenoic acids ( r s = 0.415 0.340,...
Genome size varies dramatically across species, but despite an abundance of attention there is little agreement on the relative contributions selective and neutral processes in governing this variation. The rate sex can potentially play important role genome evolution because its effect efficacy selection transmission transposable elements (TEs). Here, we used a phylogenetic comparative approach whole sequencing to investigate contribution TE content variation evening primrose (Oenothera)...
Abstract Background Accumulation of saturated fatty acids (SFAs) in the liver is known to induce hepatic steatosis and inflammation causing non-alcoholic disease (NAFLD) steatohepatitis (NASH). Although SFAs have been shown affect epigenome whole blood, pancreatic islets, adipose tissue humans, genome-wide DNA methylation studies linked epigenetic changes NAFLD NASH, focusing on association human are missing. We, therefore, investigated whether SFA content associates with tested if...