A5030872696- Immune Response and Inflammation
- Lower Extremity Biomechanics and Pathologies
- Osteoarthritis Treatment and Mechanisms
- Glycosylation and Glycoproteins Research
- Gut microbiota and health
- Probiotics and Fermented Foods
- T-cell and B-cell Immunology
- Adipokines, Inflammation, and Metabolic Diseases
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Veterinary Equine Medical Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Influenza Virus Research Studies
- Respiratory viral infections research
- Immunotherapy and Immune Responses
- Antibiotics Pharmacokinetics and Efficacy
Technical University of Denmark
2024-2025
University of Copenhagen
1973
Rigshospitalet
1973
Background Four influenza pandemics have occurred during the past 100 years, and new variants of viruses will continue to emerge. The nasal mucosa acts as primary site exposure A virus (IAV) infection, but viral recognition host immune responses in are still poorly understood. Objectives This study aimed evaluate utility non-invasive nasopharyngeal swabs for longitudinal monitoring mucosal pigs experimentally challenged with two swine-adapted one human-adapted IAV. By tracking antiviral from...
Osteoarthritis (OA) remains a major cause of lameness in horses, which leads to lost days training and early retirement. Still, the underlying pathological processes are poorly understood. MicroRNAs (miRNAs) small non-coding RNAs that serve as regulators many biological including OA. Analysis miRNA expression diseased joint tissues such cartilage synovial membrane may help elucidate OA pathology. Since integrin α10β1-selected mesenchymal stem cell (integrin α10-MSC) have shown mitigating...
In recent years, it has become apparent that imbalances in the gastrointestinal system can impact organs beyond intestine such as lungs. Given established ability of probiotics to modulate immune by interacting with cells, our research aimed investigate whether administering probiotic strain Bacillus subtilis-597 could mitigate outcome influenza virus infection pigs. Pigs were fed a diet either or without B. for 14 days before being intranasally inoculated swine A H1N2 (1 C.2 lineage)....
Following oral administration of trimethoprim (TMP) in doses varying from 5.7 to 9.8 mg TMP per kg body weight 24 h over a period 1–22 days, the concentration was determined normal and pathological lung Concentration tissue (obtained by open biopsy) total 45 cases. A microbiological method used determine concentration, using Bacillus pumilus as test organism. The found be significantly higher than serum. increased macroscopically varied 1 8½ times corresponding serum (the median ratio = 3½),...
Abstract Dendritic cells (DCs) are central for the initiation and regulation of appropriate immune responses. While several studies suggest important regulatory roles sialoglycans in DC biology, our understanding is still inadequate primarily due to a lack models. Previous approaches based on enzymatic- or metabolic-glycoengineering primary cell isolation from genetically modified mice have limitations related specificity, stability, species differences. This study addresses these challenges...
Introduction Influenza A virus (IAV) infection is a global respiratory disease, which annually leads to 3-5 million cases of severe illness, resulting in 290,000-650,000 deaths. Additionally, during the past century, four IAV pandemics have claimed millions human lives. The epithelial lining trachea plays vital role infection, both as point viral entry and replication well antiviral immune response. Tracheal tissue generally inaccessible from patients, makes animal models crucial for study...
<title>Abstract</title> Meta-inflammation (chronic, low-grade systemic inflammation) is increasingly recognized as an essential link between obesity and the development of various non-communicable diseases. However, large animal models for studying obesity-related meta-inflammation are lacking. Minipigs have great potential human diseases, warranting investigation performance Göttingen minipig a model obesity-associated meta-inflammation. Twenty-six pigs were fed high fat, fructose,...