A5103071213- Land Use and Ecosystem Services
- Genetics, Aging, and Longevity in Model Organisms
- Environmental Changes in China
- Remote Sensing and Land Use
- Rangeland Management and Livestock Ecology
- Remote Sensing in Agriculture
- Autophagy in Disease and Therapy
- Cellular transport and secretion
- Metabolism and Genetic Disorders
- Circadian rhythm and melatonin
- Mitochondrial Function and Pathology
- Trace Elements in Health
- Endoplasmic Reticulum Stress and Disease
- Photosynthetic Processes and Mechanisms
- Conservation, Biodiversity, and Resource Management
- Regional Development and Environment
- Tree-ring climate responses
- Calcium signaling and nucleotide metabolism
- Ecology and Conservation Studies
- Chinese history and philosophy
- Medical Imaging and Pathology Studies
- Evaluation Methods in Various Fields
- Extracellular vesicles in disease
- RNA regulation and disease
- Phagocytosis and Immune Regulation
Shanxi University of Finance and Economics
2022-2025
Yunnan University
2019-2024
Institute of Geographic Sciences and Natural Resources Research
2015-2024
Chinese Academy of Sciences
2017-2024
Peking University Third Hospital
2023
Peking University
2023
University of Chinese Academy of Sciences
2018-2020
Institute of Biophysics
2017
Lysosomes play important roles in cellular degradation to maintain cell homeostasis. In order understand whether and how lysosomes alter with age contribute lifespan regulation, we characterized multiple properties of during the aging process C. elegans. We uncovered age-dependent alterations lysosomal morphology, motility, acidity activity, all which indicate a decline lysosome function age. The age-associated changes are suppressed long-lived mutants daf-2, eat-2 isp-1, extend by...
Abstract Zn 2+ is required for the activity of many mitochondrial proteins, which regulate dynamics, apoptosis and mitophagy. However, it not understood how proper level achieved to maintain homeostasis. Using Caenorhabditis elegans , we reveal here that a pair mitochondrion-localized transporters controls . We demonstrate SLC-30A9/ZnT9 exporter. Loss SLC-30A9 leads accumulation, damages mitochondria, impairs animal development shortens life span. further identify SLC-25A25/SCaMC-2 as an...
Lysosomal integrity is vital for cell homeostasis, but the underlying mechanisms are poorly understood. Here, we identify CLH-6, C. elegans ortholog of lysosomal Cl-/H+ antiporter ClC-7, as an important factor protecting integrity. Loss CLH-6 affects degradation, causing cargo accumulation and membrane rupture. Reducing delivery or increasing CPL-1/cathepsin L CPR-2/cathepsin B expression suppresses these defects. Inactivation CPL-1 CPR-2, like inactivation, digestion causes Thus, loss...
Abstract. Long-term land-use changes have profound impact on terrestrial ecosystem and the associated carbon balance. Current estimates of China’s historical emissions induced by change varies widely, where in magnitude China for 1950–2021 exhibit great uncertainties reaching as large 150 % global estimates, while national-scale a longer time period past 300 years show relative uncertainty 102 %. Here, we utilized bookkeeping method to quantify annual budget resulting from between 1000 2019,...
Understanding the characteristics of wildfires in Beijing–Tianjin–Hebei (BTH) region is crucial for improving monitoring local wildfire danger. Our investigation first establishes spatial distributions fire weather index (FWI) and satellite-observed occurrences. The FWI provides a reasonably accurate representation danger BTH region. Through Self-Organizing Maps (SOM) clustering analysis, we identify nine distinct patterns composites. Notably, annual frequency SOM modes 2 7 has shown...
Apoptotic cells generated by programmed cell death are engulfed phagocytes and enclosed within membrane-bound phagosomes. Maturation of apoptotic cell–containing phagosomes leads to formation phagolysosomes where corpses degraded. The class III phosphatidylinositol 3-kinase (PI3-kinase) VPS-34 coordinates with PIKI-1, a II PI3-kinase, produce PtdIns3P on phagosomes, thus promoting phagosome closure maturation. Here, we identified UBC-13, an E2 ubiquitin–conjugating enzyme that functions in...
To evaluate and improve datasets of anthropogenic land cover change used in local global climate models, great efforts were made to reconstruct historical use, including the LandCover 6k project which dedicated reconstructing human use over past 10,000 years. In this study, we utilized records, taxed-cropland cropland measurement areas, data on number households eastern China between 10th century 13th concert with coefficient calibration, model allocation, per capita estimation areas...
Multivesicular bodies (MVBs) contain intralumenal vesicles that are delivered to lysosomes for degradation or released extracellularly intercellular signaling. Here, we identified Caenorhabditis elegans filamin FLN-2 as a novel regulator of MVB biogenesis. co-localizes with V-ATPase subunits on MVBs, and the loss affects biogenesis, reducing number MVBs in C. hypodermis. associates actin filaments is required F-actin organization. Like fln-2(lf) mutation, inactivation V0 V1 sector inhibition...
The study of geography is centered on the regional system human-land relationship, and core geographical relationship land use change. Land most direct manifestation human activities, accompanied by changes in cover. This appropriate entry point to reveal evolution relationships. past 300 years have been intense period social change China United States. In this study, we investigated differences relations between States from perspective cover We found: (1) Cultivated land, forest grassland...
The autophagosome has two lipid bilayer membranes. outer membrane fuses with the lysosome, while inner is degraded to release autophagic contents for degradation. It remains unclear how vesicle of (called vesicle) disintegrated after autophagosome-lysosome fusion. Here, we identified C. elegans LPLA-2/M05B5.4 as a key enzyme that degrades membranous material in lysosomes. LPLA-2 homologous human PLA2G15, lysosomal phospholipase A2 family protein catalyzes cleavage phospholipids. We found...
Studying changes in land use per capita is critical for understanding the interactions between humans and ecosystems, modeling impacts of on climate systems. However, many uncertainties historical estimates significantly hinder modeling. This study estimated cropland area traditional agricultural regions China over past millennium using historical-document-based modern statistical population data. The findings showed that provinces middle lower reaches Yellow River could be characterized...
Historical grassland cover change is vital for global and regional environmental modeling; however, in China, estimates of this are rare, therefore, we propose a method to reconstruct over the past 300 years. By synthesizing remote sensing-derived Chinese land use (LULCC) data (1980-2015) potential natural vegetation simulated by relationship between environment, first determined extent (PENG) absence human activities. Then reconstructed across western China 1661 1996 at 10 km resolution...
Abstract: Tracheobronchial amyloidosis is a rare disease characterized by amyloid deposits on the tracheal and bronchial tissue. Patients with tracheobronchial are asymptomatic or exhibit symptoms, such as chronic wheezing, dyspnea, cough, that common manifestations of other disorders, including asthma. A bronchoscopic tissue biopsy using Congo red staining key standard for diagnosing amyloidosis. Treatment strategies vary depending degree airway obstruction. If obstruction significant...
Global land use/cover change (LUCC) datasets are essential for quantitatively assessing the impacts of LUCC on global change, but many uncertainties in existing seriously hamper climate modeling. Evaluating reliability is a precondition improved data quality. In this study, based regional historical document-based reconstructions, satellite-based data, and reclamation evidence Xinjiang area China, accuracy rationality cropland HYDE 3.2 SAGE were evaluated by utilizing comparative analysis...