A5045980918- Bacteriophages and microbial interactions
- Retinal Diseases and Treatments
- Bacterial Genetics and Biotechnology
- Tissue Engineering and Regenerative Medicine
- Retinal Imaging and Analysis
- RNA and protein synthesis mechanisms
- Enzyme Structure and Function
- Congenital heart defects research
- Retinal and Optic Conditions
- Antimicrobial Resistance in Staphylococcus
- Cancer therapeutics and mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Glaucoma and retinal disorders
- Light effects on plants
- Photosynthetic Processes and Mechanisms
- Synthesis and biological activity
- Plant Molecular Biology Research
- Antibiotic Resistance in Bacteria
- Infectious Aortic and Vascular Conditions
- Chemical Synthesis and Analysis
- Extracellular vesicles in disease
- Pluripotent Stem Cells Research
- Genomics and Phylogenetic Studies
- Electrospun Nanofibers in Biomedical Applications
- Monoclonal and Polyclonal Antibodies Research
Johnson University
2017-2024
Western University of Health Sciences
2022-2024
Rutgers, The State University of New Jersey
1993-2024
The macular pigment optical density (MPOD) signifies a vital component of well-being and high-resolution visual acuity. MPOD can serve as reliable biomarker for assessing the retinal defense mechanisms against oxidative stress deleterious effects excessive light exposure. Elevated levels offer robust protection onset progression age-related degeneration (AMD) prevalent cause vision impairment among elderly population. MPOD's implications in diverse ocular conditions, including diabetic...
Significance There are many questions related to the origin of life and how we came rely on an almost universal system encode all as know it today. The genetic code is both robust redundant, yet also full interesting anomalies. Here explore one these anomalies, specifically existence two separate boxes/classes serine codons, AGU/C UCU/C/A/G. Unlike other synonymous codons encoding amino acid, for require a two-base substitution in order go from box remain serine. Deciphering this be will...
The genes encoding the major light-harvesting antenna chlorophyll a/b-binding protein (Cab) of higher plants are regulated by light at transcriptional level. In addition, their expression is largely restricted to photosynthetically competent organs such as leaves. A 268 bp fragment Cab-1 promoter from wheat functions a light-responsive and organ-specific enhancer in transgenic tobacco. Using DNase I footprinting, four different regions have been mapped (Cab1-A, Cab1-B, Cab1-C Cab1-D) this...
Toxin–antitoxin (TA) systems consist of a toxin inhibiting essential cellular functions (such as DNA, RNA and protein synthesis), its cognate antitoxin neutralizing the toxicity. Recently, we identified TA system termed TsbA/TsbT in Staphylococcus aureus genome. The induction tsbT gene Escherichia coli halted both DNA synthesis, reduced supercoiled plasmid resulted increasingly relaxed DNA. These results suggested that gyrase was target TsbT. In addition, TsbT inhibited E. S. activity...
Bacterial toxin‐antitoxin (TA) systems consist of a toxin that inhibits essential cellular processes, such as DNA replication, transcription, translation, or ATP synthesis, and an antitoxin neutralizing their cognate toxin. These have roles in programmed cell death, defense against phage, the formation persister cells. Here, we characterized previously identified Staphylococcus aureus TA system, tsaAT , which consists two putative membrane proteins: TsaT TsaA. Expression caused death...