A5030643981- Pancreatitis Pathology and Treatment
- Flow Measurement and Analysis
- Hydrology and Watershed Management Studies
- Pharmacological Effects of Natural Compounds
- Hydrology and Sediment Transport Processes
- Advanced Cellulose Research Studies
- Liver Disease Diagnosis and Treatment
- Ginseng Biological Effects and Applications
- Phytochemistry and biological activity of medicinal plants
- Fault Detection and Control Systems
- Advanced Sensor and Control Systems
- Microbial Metabolism and Applications
- Acute Kidney Injury Research
- Ginger and Zingiberaceae research
- Organ Transplantation Techniques and Outcomes
- Hydraulic flow and structures
- Flood Risk Assessment and Management
- Water Systems and Optimization
- High voltage insulation and dielectric phenomena
- Chemotherapy-induced organ toxicity mitigation
- Remote Sensing and LiDAR Applications
- Hydrological Forecasting Using AI
- Neurological Complications and Syndromes
- Teleoperation and Haptic Systems
- VLSI and Analog Circuit Testing
Dong-Eui University
2025
Jeonbuk National University
2021-2023
Wonkwang University
2019-2021
Yonsei University
2021
Seoul St. Mary's Hospital
2013
Inha University
2011
Korea Institute of Civil Engineering and Building Technology
2011
CHA University
2009
Korea Institute of Science and Technology
2002
Cisplatin is the most widely used chemotherapeutic agent. However, it often causes nephrotoxicity, which results in acute kidney injury (AKI). Therefore, we urgently need a drug that can reduce nephrotoxicity induced by cisplatin. Loganin major iridoid glycoside isolated from Corni fructus has been as an anti-inflammatory agent various pathological models. renal protective activity of loganin remains unclear. In this study, to examine effect on cisplatin-induced AKI, male C57BL/6 mice were...
Chronic pancreatitis (CP) is an invasive inflammatory disorder characterized by endocrine and exocrine dysfunction. There are currently no effective drugs for the treatment of CP. The present study investigated whether curcumin improves cerulein‑induced CP fibrosis in a mouse model pancreatic stellate cells (PSCs). was established intraperitoneally injecting cerulein (50 µg/kg) 3 weeks (six times at 1 h intervals/day; 4 days/week). To investigate effects curcumin, dimethyl sulfoxide or...
Chronic pancreatitis (CP) is characterized by recurrent pancreatic injury, resulting in inflammation and fibrosis. Currently, there are no drugs for the treatment of fibrosis associated with CP. Piperine, a natural alkaloid found black pepper, has been reported to show anti‑inflammatory, anti‑oxidative, antitumor activities. Although piperine exhibits numerous properties regards regulation diverse diseases, effects on CP have not established. To investigate vivo, we induced mice through...
There are three types of bile duct cancer, intrahepatic cholangiocarcinoma (ICC), hilar (HC), and extrahepatic (EHC). Despite different clinical presentation, the same protocol has been used in treatment patients with these cancers. We analyzed clinicopathologic findings protein expression order to investigate difference specific prognostic factors among cancers.We conducted a retrospective review 104 diagnosed cancer at Seoul St. Mary's Hospital between January 1994 May 2004. performed...
The major role of inner medullary collecting duct (IMCD) cells is to maintain water and sodium homeostasis. In addition the role, it also participates in protection renal systemic inflammation. Although IMCD could take part inflammation, investigations on inflammation have rarely been reported. berberine (BBR) has reported show diverse pharmacological effects, its anti‑inflammatory protective effects not studied. Therefore, present study, we examined BBR mouse IMCD‑3 (mIMCD‑3) against...
Chronic liver injury due to various hepatotoxic stimuli commonly leads fibrosis, which is a crucial factor contributing disease-related mortality. Despite the potential benefits of Suaeda glauca (S. glauca) as natural product, its biological and therapeutic effects are barely known. This study investigated S. extract (SGE), obtained from smart farming system utilizing LED lamps, on activation hepatic stellate cells (HSCs) development fibrosis. C57BL/6 mice received oral administration either...
Objectives: This study utilized a network pharmacology approach to investigate the potential therapeutic effects and underlying mechanisms of Daehwangmokdanpi-tang (DHMDPT) in diabetic cognitive disorder (DCD).Methods: The compounds DHMDPT their target genes were obtained from OASIS PubChem databases. These putative compared with known targets DCD identify correlations. Using Cytoscape 3.10.2, was constructed highlight key genes. To further elucidate mechanisms, functional enrichment...
In this study, we investigated the anti-inflammatory effects of silymarin on cerulein-induced acute pancreatitis (AP) in mice.Cerulein (50 μg/kg) was injected intraperitoneally once hourly for 6 hours to induce AP. To investigate prophylactic silymarin, dimethyl sulfoxide or (25, 50, and 100 mg/kg) 1 hour before cerulein injection. therapeutic (100 1, 3, 5 after first Blood, pancreas, lungs were harvested last injection.Pre- posttreatment with decreased pancreas weight/body weight ratio...
Mesenchymal stem cells (MSCs) have unique immunologic properties that may someday prove useful in cell-based therapy for various degenerative diseases. Its potential is limited, however, by several factors, including the rarity of these and difficulty isolating them. To evaluate their as new sources cell therapy, we isolated MSCs from human fetal tissue (hfMSC) derived spontaneous abortus (8∼10 weeks) then studied cycle surface marker expression using a fluorescence-activated sorter (FACS),...
The Glycyrrhiza radix (Licorice) is one of the most commonly used medicinal plants in Asian countries, such as China, India, and Korea. It has been traditionally to treat many diseases, including cough, cold, asthma, fatigue, gastritis, respiratory tract infections. A new variety, Wongam (WG), developed by Korea Rural Development Administration revealed pharmacological effects. However, potential adverse effects WG have not yet. This study evaluates general toxicity extract through a single...
커피의 생리활성을 증진시키기 위해 고체발효를 이용하여 인도네시아산 Mandheling 커피생두에 3종의 버섯 균사체(Phellinus linteus, PL; Hericium erinaceum, HE; Ganoderma lucidum, GL) 및 2종의 홍국균 균사체(Monascus purpureus, MP; Monascus ruber, MR)를 배양하였다. 균사체-고체발효 커피생두를 로스팅하여 얻은 원두커피는 decoction법에 의한 열수추출물과 reflux에 에탄올추출물로 조제하였는데, 열수추출물(HW, 수율 17.7～25.3%)은 에탄올추출물(EE, 9.5～12.2%)보다 더 높은 수율을 나타내었다. 커피생두로부터 조제된 원두커피 열수추출물(MP-CB-HW, MR-CB-HW)은 비발효 또는 3종 열수추출물보다 총 폴리페놀 플라보노이드 함량과 DPPH 자유라디칼 소거능을 또한, 중에서도 MR-CB-HW는 가장 마크로파지 활성과 마이토젠 활성을 나타내었다(CB-HW의...
Acute pancreatitis (AP) is an inflammatory disease of the pancreas. Icariin (ICA), a flavonoid glycoside, has been reported to have several pharmacological effects; however, anti‑inflammatory effects ICA against AP require further study. Therefore, we aimed investigate effect on cerulein‑induced AP. In present study, was induced by intraperitoneally administering supramaximal concentration cerulein (50 µg/kg/h) for 6 h. also administered intraperitoneally, and mice were sacrificed h after...
Nardostachys spp. have been widely used in Asia as a folk medicine. In particular, the extracts of jatamansi, species that grows China, India, and Tibet, to treat mental disorders, hyperlipidemia, hypertension, convulsions. this investigation, potential 20% aqueous ethanol extract N. jatamansi (NJ20) botanical drug was explored by chemically investigating its constituents anti-neuroinflammatory effects on lipopolysaccharide- (LPS-) induced vitro vivo models. Nine secondary metabolites were...
Haptic is one of well-considered device which suitable for demanding virtual reality applications such as medical equipment, mobile devices, the online marketing and so on. Nowadays, many concepts haptic devices have been suggested to meet demand industries. Cellulose has received much attention an emerging smart material, named electro-active paper (EAPap). The EAPap attractive due its unique characteristics in terms low actuation power, suitability thin transparency. In this paper, we...
Acute kidney injury (AKI) is a major side effect of cisplatin, crucial anticancer agent. Therefore, it necessary to develop drugs protect against cisplatin-induced nephrotoxicity. Ojeoksan (OJS), traditional blended herbal prescription, mostly used in Korea; however, there are no reports on the efficacy OJS AKI. To investigate reno-protective AKI, we orally administered 50, 100, and 200 mg/kg mice 1 h before intraperitoneal injection with 20 cisplatin. inhibited increase blood urea nitrogen...
ADCP는 음파의 도플러 효과를 이용하여 하천을 횡단하면서 단시간에 유속과 유량을 측정할 수 있는 장비이다. 본 연구는 현장 하천에서 ADCP를 이동식으로 운용하여 측정한 유속, 유량 자료를 동일한 지점에서 유속-면적법과 비교하여 이용한 자료의 특성을 살펴볼 목적으로 수행되었다. ADCP에 의해 측정된 수심 분포는 직접 측심에 분포와 거의 일치하였다. ADCP로 유속은 순간적이므로 개별 연직유속분포는 시간평균한 유속-면적법 자료와 차이가 있었으나 유속 측선의 좌우에 근접한 공간적으로 평균할 경우 그 차이는 감소하고 유사한 패턴을 나타내었으며, 왕복하여 반복한 측정 경우에도 비슷한 연직유속분포를 나타내었다. 수평유속분포의 ADCP의 자료 및 이를 중간단면적법에 해당하는 구간 하폭만큼 평균한 역시 잘 일치하는 양상을 유량의 한 회 이상 값은 <TEX>$0.1\%{\~}9.3\%$</TEX>의 나는 것으로 조사되었으며, 반복 횟수를 늘릴 대비 오차가 감소하는 나타났다. The...
본 연구에서는 연속적인 수위 자료를 이용하여 경사면적법으로 유량을 산정하고 그 결과를 분석하였다. 대상 하천은 괴산댐 하류의 달천으로 여울과 웅덩이를 포함하는 약 960m의 구간이다. 하상 재료의 입경을 분석하였고 이를 3가지 조도계수값을 산정하여 유량 계산에 활용하였으며, 추가로 하천정비기본계획의 조도계수도 사용되었다. 계산된 유량은 댐 방류량과 비교되었다. 비교한 상대오차는 조도계수에 큰 영향을 받는 것으로 나타났으며, 연구 구간에 적절한 조도계수는 0.042 이상인 나타났다. 구간의 평균하상 경사보다 완만한 수면경사를 갖는 계산 구간에서는 구간 전체의 조도계수보다 낮은 조도계수를 사용할 경우 오차가 적었으며, 수면경사가 평균하상경사보다 급한 크게 사용하여야 상대오차가 감소하는 하도의 전체적인 하상경사를 고려하여 설정할 경우에는 구간과 구간을 모두 포함하도록 전체 설정하는 것이 500 cms 이상의 유량에서는 실측 유량과의 상대 일정해지므로, 비교 측정이 이루어질 검증한...
Most existing teleoperation systems use video information for an operator to manipulate a remote system, or partially with force information. But these remain merely as assisting human perception. A new concept is presented, active guidance (AOG), which comprehensive of well guiding tool using virtual environment from monitoring level (passive) up reaction (active). Two case studies explain how such AOG in teleoperation. The results show that powerful precise and vital
Stress is a well-known factor for inflammation in diverse organs/tissues. also leads to liver injury, which was supported by clinical observations and animal studies. We herein investigated the hepatoprotective property of an herbal formula (called as CGplus) consisting Artemisia gmelinii Weber ex Stechm. (syn, iwayomogi Kitamura), Wurfbainia villosa var. xanthioides (Wall. Baker) Skornick. & A.D.Poulsen Amomum Wallich), Salvia miltiorrhiza Bunge against stress-induced hepatic damage.Male...
Our previous report revealed that Gardenia jasminoides (GJ) has protective effects against acute pancreatitis. So, we examined whether aqueous extract of GJ anti-inflammation and antifibrotic even cerulein-induced chronic pancreatitis (CP). CP was induced in mice by an intraperitoneal injection a stable cholecystokinin (CCK) analogue, cerulein, six times day, four days per week for three weeks. (0.1 or 1[Formula: see text]g/kg) saline (control group) were intraperitoneally injected text]h...
In this paper, feasibility of a wireless mechanical strain sensor based on dipole antenna is investigated. The geometry, deformation and load impedance feeding lines for can change the electromagnetic resonance frequency, magnitude phase angle antenna. Planar designed X band made flexible polymer substrate fabricated using conventional photolithography process. Fabricated attached to plastic cantilever beam. return loss characterized network analyzer. sensitivity tested by correlating...