A5076846612- Spine and Intervertebral Disc Pathology
- Ginseng Biological Effects and Applications
- Musculoskeletal pain and rehabilitation
- Healthcare and Venom Research
- Plant tissue culture and regeneration
- Metal complexes synthesis and properties
- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Osteoarthritis Treatment and Mechanisms
- Traditional Chinese Medicine Studies
- Magnetism in coordination complexes
- Traditional Chinese Medicine Analysis
- Robotics and Sensor-Based Localization
- Genomics and Phylogenetic Studies
- Indoor and Outdoor Localization Technologies
- Synthesis and Biological Evaluation
- Plant Molecular Biology Research
- Analytical Chemistry and Sensors
- Wound Healing and Treatments
- Spinal Cord Injury Research
- Electrochemical Analysis and Applications
- BRCA gene mutations in cancer
- Burn Injury Management and Outcomes
- Caveolin-1 and cellular processes
- Plant Gene Expression Analysis
XinHua Hospital
2024-2025
Wenzhou Medical University
2023-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2023-2024
Guangdong Pharmaceutical University
2012-2023
Key Laboratory of Guangdong Province
2022
Weatherford College
2021
Hainan 301 Hospital
2021
Sun Yat-sen University
2007-2010
Ministry of Education of the People's Republic of China
2006
The University of Texas at Arlington
1993-1996
As intervertebral disc degeneration (IVDD) proceeds, the dysfunctional mitochondria disrupt viability of nucleus pulposus cells, initiating degradation extracellular matrix. To date, there is a lack effective therapies targeting cells. Here, we synthesized polygallic acid-manganese (PGA-Mn) nanoparticles via self-assembly polymerization gallic acid in an aqueous medium and introduced mitochondrial peptide (TP04) onto using Schiff base linkage, resulting PGA-Mn-TP04 nanoparticles. With size...
Osteoarthritis (OA) is a chronic inflammatory joint disease characterized by progressive cartilage degeneration, synovitis, and osteoid formation. In order to effectively treat OA, it important block the harmful feedback caused reactive oxygen species (ROS) produced during wear. To address this challenge, we have developed injectable nanocomposite hydrogels composed of polygallate-Mn (PGA-Mn) nanoparticles, oxidized sodium alginate, gelatin. The inclusion PGA-Mn not only enhances mechanical...
Intervertebral disc degeneration (IVDD) is a significant contributor to low back pain, characterized by excessive reactive oxygen species generation and inflammation-induced pyroptosis. Unfortunately, there are currently no specific molecules or materials available effectively delay IVDD. This study develops multifunctional full name of PG@Cu nanoparticle network (PG@Cu). A designed pentapeptide, bonded on nanoparticles via Schiff base bond, imparts multifunctionality the metal polyphenol...
Intervertebral disc degeneration (IVDD) is a chronic degenerative disease involving the aging and loss of proliferative capacity nucleus pulposus cells (NPCs), processes heavily dependent on mitochondrial dynamics autophagic flux. This study finds that absence BCL2/adenovirus E1B 19 kDa interacting protein 3 (BNIP3) associated with senescence-related NPC degeneration, disrupting quality control. Bone marrow mesenchymal stem (BMSCs) have multidirectional differentiation potential produce...
Abstract The treatment of intervertebral disc degeneration (IVDD) using bone marrow mesenchymal stem cell‐derived exosomes has shown success in alleviating inflammation and restoring the extracellular matrix (ECM), however, challenges persist due to deficiency mechanical support controlled release. Herein, a carbon‐carbon double bond modified keratin (KeMA) is synthesized by 2‐isocyanatoethyl modification for wrapping. This injectable KeMA hydrogel, initiated biocompatible glucose/ glucose...
Background Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by systemic inflammation and immune dysregulation, leading to higher risk of all-cause mortality. The Pan-Immune Inflammation Value (PIV), novel biomarker capturing immune-inflammatory activity, has shown prognostic value in various diseases. However, its role predicting outcomes RA patients remains largely unexplored. Objectives This study aimed evaluate the association between PIV mortality patients, investigate...
Intervertebral disc degeneration (IVDD) is a leading cause of low back pain. The strategy using functional materials to deliver nucleic acids provides powerful tool for ameliorating IVDD. However, the immunogenicity acid vectors and poor mechanical properties greatly limit their effects. Herein, antagomir-204-3p (AM) shows effectively inhibits apoptosis nucleus pulposus cells. Moreover, high-strength biohydrogel based on zinc-oxidized sodium alginate-gelatin (ZOG) designed as multifunctional...
Abstract Developing functional medical materials is urgent to treat diabetic wounds with a high risk of bacterial infections, glucose levels and oxidative stress. Here, smart copper‐based nanocomposite acidic spray has been specifically designed address this challenge. This pH‐responsive multienzyme‐like properties. It enables the effectively eliminate bacteria alleviate tissue pressure, thereby accelerating healing infected wounds. The works by generating hydroxyl radicals through...
Abstract Intervertebral disc degeneration (IVDD) is a major cause of low back pain, where oxidative stress and mitochondrial dysfunction are key contributors. Additionally, ferroptosis, an iron‐dependent form cell death, identified as critical mechanism in IVDD pathogenesis. Herein, the therapeutic potential gallic acid (GA)‐derived PGA‐Cu nanoparticles, enhanced with functional octapeptide (Cys‐Lys‐His‐Gly‐ d ‐Arg‐ ‐Tyr‐Lys‐Phe, SS08) to build mitochondria‐targeted nanoparticles...
Context: The recent developments in non-viral gene therapy and DNA vaccine have fostered the development of efficient plasmid (pDNA) purification processes.Objectives: This work aimed to establish a cost-effective process for large-scale production vaccine.Materials methods: E. coli DH5α harboring pCDNA3.1-GFP (7200 base pairs) was used as model plasmid. Hydrophobic-interaction chromatography (HIC) employed purify supercoiled (sc pDNA).Results: With this method, not only host contaminants,...
Abstract
The alkali cation (Li+, Na+, K+, Rb+, and Cs+) binding properties of cryptands [2.1.1], [2.2.1], [2.2.2] were investigated under solvent-free, gas-phase conditions using Fourier transform ion cyclotron resonance mass spectrometry. cations serve as size probes for the cryptand cavities. All three readily form 1:1 complexes. Ligand−metal (2:1) complexes [2.1.1] with Cs+, [2.2.1] Rb+ Cs+ observed, but no 2:1 seen, consistent formation "inclusive" rather than "exclusive" when cavity ligand is...
Three new Ru(II) complexes, [Ru(dmb)2(ipad)](ClO4)2 (dmb = 4,4′-dimethyl-2,2′-bipyridine, ipad 2-(anthracene-9,10-dione-2-yl) imidazo[4,5-f][1,10]phenanthroline, 1), [Ru(dmp)2(ipad)](ClO4)2 (dmp 2,9-dimethyl-1,10-phenanthroline, 2), and [Ru(dip)2(ipad)](ClO4)2 (dip 4,7-diphenyl-1,10-phenanthroline, 3), have been synthesized characterized. The three complexes intercalate with the base pairs of DNA. in vitro antiproliferative activities apoptosis-inducing characteristics these were...
Intervertebral disc degeneration (IVDD) is a leading cause of low back pain. The strategy delivering nucleic acids with functional materials provides powerful tool for ameliorating IVDD. However, the immunogenicity acid vectors and poor mechanical property greatly limit their effects. Herein, antagomir-204-3p shows can effectively inhibit apoptosis nucleus pulposus cells. Moreover, high-strength bio-hydrogel based on zinc-oxidized sodium alginate-gelatin (ZOG) designed as multifunctional...