A5061966176- Chronic Kidney Disease and Diabetes
- IL-33, ST2, and ILC Pathways
- Kidney Stones and Urolithiasis Treatments
- Dialysis and Renal Disease Management
- Eosinophilic Esophagitis
- Cell Adhesion Molecules Research
- Trace Elements in Health
- T-cell and B-cell Immunology
- Renal Diseases and Glomerulopathies
- Drug-Induced Hepatotoxicity and Protection
- Muscle and Compartmental Disorders
- Food Allergy and Anaphylaxis Research
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- CAR-T cell therapy research
- Inflammasome and immune disorders
- Gout, Hyperuricemia, Uric Acid
University Hospital Bonn
2016-2024
University of Bonn
2017-2018
Abstract Regulatory T cells (Tregs) maintain self‐tolerance and prevent autoimmunity by controlling autoreactive cells. We recently demonstrated in vivo that Tregs can directly suppress auto‐reactive B via programmed death ligand 1 ( PD ‐L1) ligated ‐1 on caused them to undergo apoptosis. Here, we asked whether this mechanism is utilized thymus‐derived natural and/or peripheral lymphoid tissue‐induced Tregs. first antigen‐specific ‐L1‐expressing were induced the draining lymph node of...
Chronic inflammasome activation in mononuclear phagocytes (MNPs) promotes fibrosis various tissues, including the kidney. The cellular and molecular links between are unclear. To address this question, we fed mice lacking immunological mediators an adenine-enriched diet, which causes crystal precipitation renal tubules, crystal-induced activation, fibrosis. We found that kidney depended on intrarenal inflammasome-dependent type 3 immune response driven by its signature transcription factor...