A5004269276- RNA Interference and Gene Delivery
- Mosquito-borne diseases and control
- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Research and Treatments
- HIV Research and Treatment
- Heat shock proteins research
- Vector-borne infectious diseases
- RNA regulation and disease
- Viral gastroenteritis research and epidemiology
- Bacteriophages and microbial interactions
- Advanced Electron Microscopy Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Ultrasound and Hyperthermia Applications
- Endoplasmic Reticulum Stress and Disease
- Barrier Structure and Function Studies
Abstract Here we conducted a multicenter open-label, randomized phase 2 and 3 study to assess the safety immunogenicity of severe acute respiratory syndrome coronavirus (SARS-CoV-2) Omicron-specific (BA.1/B.1.1.529), monovalent, thermostable, self-amplifying mRNA vaccine, GEMCOVAC-OM, when administered intradermally as booster in healthy adults who had received two doses BBV152 or ChAdOx1 nCoV-19. GEMCOVAC-OM was well tolerated with no related serious adverse events both 3. In 2, compared...
Selecting a booster vaccine strategy that generates cellular immune breadth is crucial for effectively recalling reservoirs upon infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants. This post hoc analysis from multicentre, randomized phase 3 study (CTRI/2022/10/046475) compared the induced by self-replicating mRNA (samRNA) GEMCOVAC-OM, encoding Omicron B.1.1.529 Spike protein, adenovector ChAdOx1 nCoV-19, Wuhan variant when administered as booster....
Emerging evidence suggests that antibodies against merozoite proteins involved in P. falciparum invasion into the red blood cell (RBC) play an important role clinical immunity to malaria. The protein family of parasite antigens known as Reticulocyte Binding Protein Homologue (PfRh) is required for RBC invasion. PfRh5 only member within PfRh cannot be genetically deleted, suggesting it plays essential survival. This antigen forms a complex with cysteine-rich Rh5 interacting (PfRipr), on...
Our goal is to overcome treatment resistance in ovarian cancer patients which occurs most cases after an initial positive response chemotherapy. A central mechanism the maintenance of desmoglein-2 (DSG2) tight junctions between malignant cells that prevents drug penetration into tumor. We have generated JO4, a recombinant protein binds DSG2 resulting transient opening epithelial tumors. Here we present studies toward clinical translation c-JO4 combination with PEGylated liposomal...
Abstract Our goal is to overcome treatment resistance in ovarian cancer patients, which occurs most cases after an initial positive response chemotherapy. A central mechanism the maintenance of desmoglein-2 (DSG2)-positive tight junctions between malignant cells, prevents drug penetration into tumor. We generated JO4, a recombinant protein that binds DSG2, resulting transient opening epithelial tumors. Here, we present studies on clinical translation JO4 combination with PEGylated liposomal...