A5101680313- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- RNA and protein synthesis mechanisms
- Bacteriophages and microbial interactions
- Animal Virus Infections Studies
- Glycosylation and Glycoproteins Research
- Phytochemicals and Medicinal Plants
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Ethnobotanical and Medicinal Plants Studies
- Mycobacterium research and diagnosis
- Child and Adolescent Health
- Water Treatment and Disinfection
- Water Quality Monitoring and Analysis
- Agricultural Economics and Practices
- Banana Cultivation and Research
- Ubiquitin and proteasome pathways
- Antimicrobial Peptides and Activities
- Genetics and Neurodevelopmental Disorders
- Child Nutrition and Feeding Issues
- Advanced Proteomics Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- vaccines and immunoinformatics approaches
- Toxin Mechanisms and Immunotoxins
- Agricultural pest management studies
Biotech Park
2023-2024
Central University of South Bihar
2022
The University of Texas MD Anderson Cancer Center
2016
King George's Medical University
2015
University of Delhi
2013
Ministry of Defence
2008
India Habitat Centre
1999
Energy and Resources Institute
1999
Abstract Here we conducted a multicenter open-label, randomized phase 2 and 3 study to assess the safety immunogenicity of severe acute respiratory syndrome coronavirus (SARS-CoV-2) Omicron-specific (BA.1/B.1.1.529), monovalent, thermostable, self-amplifying mRNA vaccine, GEMCOVAC-OM, when administered intradermally as booster in healthy adults who had received two doses BBV152 or ChAdOx1 nCoV-19. GEMCOVAC-OM was well tolerated with no related serious adverse events both 3. In 2, compared...
Selecting a booster vaccine strategy that generates cellular immune breadth is crucial for effectively recalling reservoirs upon infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants. This post hoc analysis from multicentre, randomized phase 3 study (CTRI/2022/10/046475) compared the induced by self-replicating mRNA (samRNA) GEMCOVAC-OM, encoding Omicron B.1.1.529 Spike protein, adenovector ChAdOx1 nCoV-19, Wuhan variant when administered as booster....
Withania somnifera is an important medicinal plant, and its anticancerous properties have been attributed to various classes of withanolide compounds. The objective the present study was investigate inter- intraspecific genetic variation in 35 individuals W. 5 coagulans using AFLP (amplified fragment length polymorphism) marker technique. information about determined from data for 40 employed estimate similarity matrix value based on Jaccard's coefficient. values were further used construct...
Phagemid-based expression of cloned genes fused to the gIIIP coding sequence and rescue using helper phages, such as VCSM13, has been used extensively for constructing large antibody phage display libraries. However, randomly primed cDNA gene fragment libraries, this system encounters reading frame problems wherein only one 18 phages translated foreign peptide/protein phagemid-encoded gIIIP. The elimination carrying out-of-frame inserts is vital in order improve quality In study, we designed...
Recently, mRNA has gained a lot of attention in the field vaccines, gene therapy, and protein replacement therapies. Herein, we are demonstrating comprehensive approach to designing, cloning, characterizing an antigenic cassette for development vaccine COVID-19. The encoding spike SARS-CoV-2 Omicron variant (B.1.1.529) was designed using databases, characterized by
Withania somnifera is an important medicinal plant, and its anticancerous properties have been attributed to various classes of withanolide compounds. The objective the present study was investigate inter- intraspecific genetic variation in 35 individuals W. 5 coagulans using AFLP (amplified fragment length polymorphism) marker technique. information about determined from data for 40 employed estimate similarity matrix value based on Jaccard's coefficient. values were further used construct...
Oral cancer is a common type of head and neck that affects majority the population worldwide.The present study focuses on network-based proteinprotein interaction (PPI) approach for identification oral targets systems biology approachbased analysis.Totally 47 gene were extracted from BioXpress database, Cancer Gene Database HNC database.The related protein networks explored visualized using Cytoscape v3.7.2.Topology predictions performed by Molecular Complex Detection tool Biological...
Background/Objectives: The nucleic acid-based product (NAP) portfolio is expanding continuously and provides safer curative options for many disease indications. Nucleic products offer several advantages compared to proteins virus-based products. They represent an emerging field; thus, their quality control regulatory landscape evolving ensure adequate safety. Next-Generation Sequencing (NGS) mostly recommended NAP identity testing, we are leveraging its application impurity profiling....
The genomic variability makes Influenza A virus (IAV) difficult to be con-trolled by existing vaccines or anti-influenza drugs. Viral gene targeting siRNA induces the RNAi mechanism in host and silents cleaving mRNA. Objective was develop non-structural 1 validate its efficiency vitro. designed rationally, most conserved region (delineated with help of multiple sequence align-ment) NS1 IAV strains. To choose efficient siRNA, three levels screening method developed. Ultimately one duplex...
Abstract Recently, genomics has gained a lot of attention in the field bio-therapeutics, vaccines, and gene therapy. We have developed robust pipeline for establishing mRNA vaccine portfolio to address current pandemic endemic COVID-19, infectious diseases, cancer. designed assembled approximately 4000 base pair DNA encoding spike protein SARS-CoV-2 Omicron variant (B.1.1.529) using overlapping oligo-based PCR assembly. Further, we cloned this fragment into self-amplifying platform prepared...