A5050154578- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Marine Sponges and Natural Products
- interferon and immune responses
- Oxidative Organic Chemistry Reactions
- Chemical Reactions and Isotopes
- Magnetism in coordination complexes
- Traditional and Medicinal Uses of Annonaceae
- Metal complexes synthesis and properties
- Fibroblast Growth Factor Research
- Cardiac Fibrosis and Remodeling
- Fluorine in Organic Chemistry
- Asthma and respiratory diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Redox biology and oxidative stress
- Allergic Rhinitis and Sensitization
- Asymmetric Synthesis and Catalysis
- ATP Synthase and ATPases Research
- Kruppel-like factors research
- Marine Invertebrate Physiology and Ecology
- Nanomaterials for catalytic reactions
- Viral Infections and Vectors
- Calpain Protease Function and Regulation
- Glutathione Transferases and Polymorphisms
- Ammonia Synthesis and Nitrogen Reduction
National Health Research Institutes
2020-2025
The Fifth People’s Hospital of Suzhou
2020-2023
Soochow University
2023
Soochow University
2020-2023
First Affiliated Hospital of Soochow University
2023
Chung Yuan Christian University
2014-2020
Barnard College
2019-2020
Pharmacological inhibition of the cGAS-STING-controlled innate immune pathway is an emerging therapeutic strategy for a myriad inflammatory diseases. Here, we report GHN105 as orally bioavailable covalent STING inhibitor. Late-stage diversification briarane-type diterpenoid excavatolide B allowed installation solubility-enhancing functional groups while enhancing its activity inhibitor against multiple human variants, including S154 variant responsible genetic autoimmune disease. Selectively...
Abstract Apigenin, a flavonoid isolated from Apium graveolens , is an effective natural active ingredient that inhibits transforming growth factor‐β1 (TGF‐β1)‐induced cardiac fibroblasts (CFs) differentiation and collagen synthesis. However, its effects on isoproterenol‐induced myocardial fibrosis in mice remain unknown. This study aimed to examine the effect of apigenin prevention fibrosis. A mouse model induced by isoproterenol was established, were given 75–300 mg/kg orally for 40 days....
Tylophorine-based compounds and natural cardiotonic steroids (cardenolides bufadienolides) are two classes of transmissible gastroenteritis coronavirus inhibitors, targeting viral RNA host cell factors, respectively. We tested both types against coronaviruses, to compare contrast their antiviral properties, with view further therapeutic development. Examples potently inhibited the replication feline infectious peritonitis virus human OC43 EC 50 values up 8 16 nM, Strikingly,...
Natural products are important sources of therapeutic agents and useful drug discovery tools. The fused macrocycles multiple stereocenters briarane-type diterpenoids pose a major challenge to total synthesis efforts characterize their biological activities. Harnessing scalable source excavatolide B (excB) from cultured soft coral Briareum stechei, we generated analogs by late-stage diversification performed structure-activity analysis, which was critical for the development functional excB...
Atopic dermatitis (AD) is a chronic inflammatory skin condition primarily driven by T helper 2 (Th2) cytokines, resulting in barrier defects, angiogenesis, and responses. The marine natural product excavatolide B (EXCB), isolated from the Formosan Gorgonian coral Briareum stechei, exhibits anti-inflammatory analgesic properties. To enhance solubility, EXCB chemically modified into derivatives EXCB-61 salt EXCB-79. study aims to investigate therapeutic effects of these compounds on...
Abstract A simple method for synthesizing aldehydes from α‐oxocarboxylic acids via decarboxylation in the presence of PPh 3 and Et N is reported. The can be performed on a wide range acids; electron‐rich/electron‐deficient aryl, heteroaryl, as well alkyl acids. This also provides convenient procedure synthesis deuterated using D 2 O deuterium source facile one‐pot process.
Well-defined dinuclear silver(I) complexes have been targeted for applications in catalysis and materials chemistry, the effect of close silver–silver interactions on electronic structure remains an area active inquiry. In this study, we describe synthesis, structure, photophysical properties dimeric silver featuring a redox-active naphthyridine diimine ligand. Unusually silver(I), these display absorption features visible region due to metal–metal ligand charge transfer (MMLCT) transitions,...
Abstract The objectives of this study were to investigate the effects marein, a major bioactive compound in functional food Coreopsis tinctoria , hypertrophic H9c2 cells. Treating angiotensin II/hypoxia‐stimulated cells with marein led decreasing cell surface area, intracellular total protein, atrial natriuretic peptide, and free fatty acids levels, but increasing glucose level. Marein treatment decreased hypoxia inducible factor‐1α (HIF‐1α), peroxisome proliferator activated receptor γ...
Primary aromatic amines were synthesized from the corresponding nitrobenzenes via photoinduced reduction. The reaction was found to be effective when with electron-withdrawing substituents irradiated a broad band of UV light centered at 306 nm. When reactions are completed, products could isolated by acid–base extraction or column chromatography. This presenting photoreaction procedure for synthesis primary proceeds without need sensitizer in isopropanol THF. Without usage catalysts,...
We report the formal synthesis of (±)-pentalenolactone A methyl ester from simple 2-methoxyphenol. The key features our route are as follows: a Diels-Alder reaction masked o-benzoquinone to assemble functionalized bicyclo[2.2.2]octenone, continuous-flow oxa-di-π-methane rearrangement for building diquinane core (AB ring), and an oxidative cleavage/oxidation sequence annulation δ-lactone (C ring).
Abstract Masked o ‐benzoquinones (MOBs), which were generated in situ from 2‐methoxyphenols, underwent Diels–Alder reactions with 1‐vinylcyclohexenes to produce the corresponding cycloaddition products, that is, decahydrophenanthrenes along bicyclo[2.2.2]octenones. In former case, MOBs serve as dienophile, and later act dienophile. The obtained bicyclo[2.2.2]octenones could be transformed into through a Cope rearrangement at 220 °C. Thus, these tandem provide short efficient entry...
Myocardial fibrosis significantly contributes to the pathogenesis and progression of heart failure.
Pharmacological inhibition of cGAS-STING-controlled innate immune pathway is an emerging therapeutic strategy for a myriad inflammatory diseases, including autoimmune disease, ulcerative colitis, non-alcoholic fatty liver disease and aging-related neurodegeneration. Here we report GHN105 as orally bioavailable covalent STING inhibitor. Late-stage diversification the briarane-type diterpenoid excavatolide B allowed installation solubility-enhancing functional groups while enhancing its...
Excavatolide B (1, ExcB), a briarane-type diterpenoid isolated from Formosan gorgonian Briareum stechei, exhibits promising anti-inflammatory activity with low cytotoxicity. In this study, we report the structure-activity relationship of ExcB derivatives late-stage modifications around carboframe 1. We identified potent analog 22 improved in vitro inhibitory activities against inducible nitric oxide synthase gene expression, production, IL-6, and TNF- production LPS-stimulated RAW264.7...
Abstract A broad range of functionalized aryl α‐oxocarboxylic acids as well hetaryl and alkyl substituted analogues serve effective synthons for aldehydes which may be isolated in moderate to high yields.
Abstract Masked o‐benzoquinones generated in situ from o‐methoxyphenols and methanol undergo Diels—Alder reaction with 1‐vinylcyclohexenes to provide decahydrophenanthrenes along bicyclo[2.2.2]octenone derivatives.
Background: FGF21 regulates glycolipid metabolism and insulin homeostasis acts as a cardioprotective factor by protecting against myocardial ischemia/reperfusion injury, hypertension, vascular dysfunction. has been reported to prevent Doxorubicin (Dox)-induced cardiotoxicity, the related signaling pathway is worthy of further study.Methods Results: inhibited apoptosis in Dox-treated mice cardiomyocytes. increased levels connexin43 (Cx43) phosphorylated at serine (S) 282 (p-Cx43 S282) total...